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Specialty: Biomedical Science
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Total 883 results found since Jan 2013.
H2O2 downregulate SIRT7`s protective role of endothelial premature dysfunction via microRNA-335-5p
This study analyzed the elevated levels of miR-335-5p and the decreased levels of SIRT7 in human umbilical vein endothelial cells (HUVECs) , and found that high glucose, tumour necrosis factor-α (TNF-α), and H2O2 are the three contributing factors that induced cellular senescence. The current study also assessed premature endothelial senescence and decreased proliferation, adhesion, migration, and nitric oxide secretion in HUVECs with these risk factors together with SIRT7-siRNA transfection. It found that the miR-335-5p inhibitor attenuated the downregulation of SIRT7 expression induced by oxidative stress in HUVECs, an...
Source: Bioscience Reports - January 4, 2022 Category: Biomedical Science Authors: Yixin Liu Jinyu Yang Xi Yang Peng Lai Yi Mou Juelin Deng Xinyi Li Hui Wang Xiaolei Liu Lixing Zhou Linghui Deng Ziqi Xu Chun Xiao Birong Dong Source Type: research
< em > YTHDC1 < /em > gene polymorphisms and neuroblastoma susceptibility in Chinese children
In conclusion, our findings highlight the involvement of YTHDC1 gene and its genetic variants in the etiology of NB.PMID:34897032 | DOI:10.18632/aging.203760
Source: Aging - December 13, 2021 Category: Biomedical Science Authors: Yong Li Tongyi Lu Jian Wang Zhenjian Zhuo Lei Miao Zhonghua Yang Jiao Zhang Jiwen Cheng Haixia Zhou Suhong Li Li Li Jing He Aiwu Li Source Type: research
TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure
by Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Rei Sakata, Megumi Honjo, Makoto Aihara
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but it is not well understood. We investigated that h ow transient receptor potential cation channel subfamily V member 4 (TRPV4) functions in human trabecular meshwork cells (HTMC) and affects intraocular pressure (IOP). HTMC were treated with TRPV4 siRNA...
Source: PLoS One - October 21, 2021 Category: Biomedical Science Authors: Takatoshi Uchida Source Type: research
MSCs enhances the protective effects of valsartan on attenuating the doxorubicin-induced myocardial injury via AngII/NOX/ROS/MAPK signaling pathway
CONCLUSIONS: AT1R/NOX/ROS/MAPK signaling pathway is involved in DOX-induced cardiotoxicity. Val treatment significantly attenuated DOX-induced cardiotoxicity, without affecting the anti-tumor effect of DOX. MSCs enhance the protective effects of Val on reducing the DOX-induced toxicity in H9c2 cells.PMID:34587120 | DOI:10.18632/aging.203569
Source: Aging - September 29, 2021 Category: Biomedical Science Authors: Dong Cheng Wencheng Tu Libo Chen Haoren Wang Qinfu Wang Hainiang Liu Ning Zhu Weiyi Fang Qin Yu Source Type: research
Circular RNA ZNF609 enhances proliferation and glycolysis during glioma progression by miR-378b/SLC2A1 axis
In this study, we were interested the function of circular RNA ZNF609 in modulating glioma. Remarkably, knockdown of ZNF609 by siRNA in glioma cells reduced cell viabilities and Edu-positive. The silencing of ZNF609 stimulated the apoptosis of glioma cells. Meanwhile, the ZNF609 depletion inhibited the invasion and migration of glioma cells. In glioma cells, the mRNA and protein expression of E-cadherin was enhanced, while Vimentin was reduced by the inhibition of ZNF609. The glucose uptake, lactate product, and ATP production in glioma cells were suppressed by ZNF609 knockdown. Mechanically, miR-378b was sponged by ZNF609...
Source: Aging - September 14, 2021 Category: Biomedical Science Authors: Zhihuang Zhao Gang Li Yonggang Han Yabin Li Zhisheng Ji Rui Guo Xiaohong Yu Source Type: research
Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
Aging (Albany NY). 2021 Sep 12;13(undefined). doi: 10.18632/aging.203441. Online ahead of print.ABSTRACTBetulinic acid (BA), a pentacyclic triterpenoid isolated from tree bark, exhibits antitumor effects against solid malignancies and triggers autophagy and/or apoptosis in human cancer cells. Nonetheless, the relationship between autophagy and apoptosis and the potential modulatory actions of BA on autophagy-dependent bladder cancer cell death remain unclear. The present study showed that BA exposure significantly suppressed viability, proliferation, and migration of EJ and T24 human bladder cancer cells. These effects ref...
Source: Aging - September 12, 2021 Category: Biomedical Science Authors: Yan Zhang Ning He Xuejian Zhou Feifan Wang Hairong Cai Shih Han Huang Xianwu Chen Zhenghui Hu Xiaodong Jin Source Type: research
LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells
Aging (Albany NY). 2021 Aug 30;13(undefined). doi: 10.18632/aging.203416. Online ahead of print.ABSTRACTTo explore the effects of lncRNA GACAT1/miR-149 molecular axis on the proliferation, apoptosis, migration and autophagy of oral squamous cell carcinoma (OSCC) cells, and to explore its molecular mechanism. The expressions of lncRNA GACAT1 and miR-149 in tissues and cell lines of patients with OSCC were detected by qRT-PCR. Si-control, GACAT1-siRNA, inhibitor NC and miR-149 inhibitors were transfected into OSCC cells separately or in combination with Lipofectamine 2000. The binding sites between lncRNA GACAT1 and miR-149 ...
Source: Aging - August 30, 2021 Category: Biomedical Science Authors: Jingxin Chen Xubin Chen Liangbin Fu Jimin Chen Yang Chen Feng Liu Source Type: research
Modeling stem cell nucleus mechanics using confocal microscopy
Biomech Model Mechanobiol. 2021 Aug 23. doi: 10.1007/s10237-021-01513-w. Online ahead of print.ABSTRACTNuclear mechanics is emerging as a key component of stem cell function and differentiation. While changes in nuclear structure can be visually imaged with confocal microscopy, mechanical characterization of the nucleus and its sub-cellular components require specialized testing equipment. A computational model permitting cell-specific mechanical information directly from confocal and atomic force microscopy of cell nuclei would be of great value. Here, we developed a computational framework for generating finite element m...
Source: Biomechanics and Modeling in Mechanobiology - August 23, 2021 Category: Biomedical Science Authors: Zeke Kennedy Joshua Newberg Matthew Goelzer Stefan Judex Clare K Fitzpatrick Gunes Uzer Source Type: research
Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5
In this study, we identities the epigenetic regulation function of circular RNA circRHOT1 in promoting NSCLC cell proliferation. We found that circRHOT1 were elevated in the clinical tumor tissues relative to that in the peritumor tissues from NSCLC patients. circRHOT1 was up-regulated in human lung cancer cell lines compared with normal human lung epithelial cell line. MTT assays revealed that the silencing of circRHOT1 by siRNA suppressed cell viabilities of NSCLC cells. Colony formation and Edu assays confirmed that circRHOT1 knockdown attenuated NSCLC cell proliferation in vitro. Meanwhile, the depletion of circRHOT1 i...
Source: Aging - August 18, 2021 Category: Biomedical Science Authors: Xiaoyan Ren Jiangang Yu Lili Guo Hong Ma Source Type: research
Ferumoxytol- β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype
Conclusion: The nanocomposite FMT-β-glucan suppressed melanoma growth by inducing the M1 macrophage-activated tumor microenvironment.PMID:34400883 | PMC:PMC8364471 | DOI:10.7150/ijms.61525
Source: International Journal of Medical Sciences - August 17, 2021 Category: Biomedical Science Authors: Xinghan Liu Yujun Xu Yi Li Yuchen Pan Shuli Zhao Yayi Hou Source Type: research
