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Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells
Conclusion: Targeting Ras and PI3K activity improves the outcome of irradiation in cetuximab-resistant HNSCC cell lines in vitro.
Source: Radiotherapy and Oncology - July 29, 2013 Category: Radiology Authors: Mohammad Saki, Mahmoud Toulany, H. Peter Rodemann Tags: Original Articles Source Type: research

Acquired Tumor Cell Radiation Resistance at the Treatment Site Is Mediated Through Radiation-Orchestrated Intercellular Communication
Conclusions: Together, these data strongly suggest that scattered LDIR-induced NFκB-dependent TNF-α, IL-1α, cMYC, and SOD2 mediate radiation protection to the subsequent challenge dose in tumor cells.
Source: International Journal of Radiation Oncology * Biology * Physics - January 8, 2014 Category: Radiology Authors: Natarajan Aravindan, Sheeja Aravindan, Vijayabaskar Pandian, Faizan H. Khan, Satish Kumar Ramraj, Praveen Natt, Mohan Natarajan Tags: Biology Contributions Source Type: research

Down-regulation of Autophagy-Associated Protein Increased Acquired Radio-Resistance Bladder Cancer Cells Sensitivity to Taxol.
CONCLUSIONS: Long-term FI treatment is an effective method to establish the ARR-phenotype BCa cell model, by enriching BCSCs and enhancing cells migration and invasion. Both inhibiting the expression of autophagy-related proteins and using autophagy inhibitor can increase the sensitivity of ARR cells to taxol, suggesting that autophagy may play an important role in ARR cells chemical tolerance. PMID: 33443463 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - January 16, 2021 Category: Radiology Tags: Int J Radiat Biol Source Type: research