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Specialty: Internal Medicine
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Total 101 results found since Jan 2013.
Efficient replication of blood borne Hepatitis C Virus in human fetal liver stem cells
Conclusion: Our data showed that the entire bbHCV life cycle could be naturally imitated in hFLSCs. This model is expected to provide a powerful tool for exploring the process and the mechanism of bbHCV infection at the cellular level, and evaluating the treatment and preventive strategies of bbHCV infection. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 13, 2017 Category: Internal Medicine Authors: Xuan Guo, Shu Wang, Zhi ‐Gang Qiu, Ya‐Ling Dou, Wei‐Li Liu, Dong Yang, Zhi‐Qiang Shen, Zhao‐Li Chen, Jing‐Feng Wang, Bin‐ Zhang, Xin‐Wei Wang, Xiang‐Fei Guo, Xue‐Lian Zhang, Min Jin, Jun‐Wen Li Tags: Viral Hepatitis Source Type: research
A Novel Role of Astrocyte Elevated Gene ‐1 (AEG‐1) in Regulating Non‐alcoholic Steatohepatitis (NASH)
Conclusion: AEG‐1 might be a key molecule regulating initiation and progression of NASH. AEG‐1 inhibitory strategies might be developed as a potential therapeutic intervention in NASH patients. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 24, 2017 Category: Internal Medicine Authors: Jyoti Srivastava, Chadia L. Robertson, Kareem Ebeid, Mikhail Dozmorov, Devaraja Rajasekaran, Rachel Mendoza, Ayesha Siddiq, Maaged A. Akiel, Nidhi Jariwala, Xue ‐Ning Shen, Jolene J. Windle, Mark A. Subler, Nitai D. Mukhopadhyay, Shah Giashuddin, Shobha Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Circular RNA MTO1 acts as the sponge of miR ‐9 to suppress hepatocellular carcinoma progression
Conclusion: circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR‐9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients. This article is protected by copyright. All rights reserved.
Source: Hepatology - May 18, 2017 Category: Internal Medicine Authors: Dan Han, Jiangxue Li, Huamin Wang, Xiaoping Su, Jin Hou, Yan Gu, Cheng Qian, Yun Lin, Xiang Liu, Mingyan Huang, Nan Li, Weiping Zhou, Yizhi Yu, Xuetao Cao Tags: Hepatobiliary Malignancies Source Type: research
Targeting senescent cholangiocytes and activated fibroblasts with Bcl ‐xL inhibitors ameliorates fibrosis in Mdr2‐/‐ mice
Conclusions: Bcl‐xL is a key survival factor in ASF as well as in senescent cholangiocytes. Treatment with the Bcl‐xL‐specific inhibitor A‐1331852 reduces liver fibrosis, possibly by a dual effect on activated fibroblasts and senescent cholangiocytes. This novel mechanism represents an attractive therapeutic strategy in biliary fibrosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - August 12, 2017 Category: Internal Medicine Authors: Anja Moncsek, Mohammed S. Al ‐Suraih, Christy E. Trussoni, Steven P. O'Hara, Patrick L. Splinter, Camille Zuber, Eleonora Patsenker, Piero V. Valli, Christian D. Fingas, Achim Weber, Yi Zhu, Tamar Tchkonia, James L. Kirkland, Gregory J. Gores, Beat Mül Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Cholangiocyte Autophagy Contributes to Hepatic Cystogenesis in Polycystic Liver Disease and Represents a Potential Therapeutic Target
Conclusion: Autophagy is increased in PLD cholangiocytes, contributes to hepatic cystogenesis, and represents a potential therapeutic target for disease treatment. This article is protected by copyright. All rights reserved.
Source: Hepatology - October 10, 2017 Category: Internal Medicine Authors: Anatoliy I. Masyuk, Tatyana V. Masyuk, Maria J. Lorenzo Pisarello, Jingyi (Francess) Ding, Lorena Loarca, Bing Q. Huang, Nicholas F. LaRusso Tags: Liver Biology and Pathobiology Source Type: research
Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease
Conclusion:
Overexpression of TRPC1 in COPD promoted EMT process and TRPC1 may be a new and interesting focus for COPD new treatment in the future.
Source: Medicine - October 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Polo ‐like‐kinase 1 is a proviral host factor for hepatitis B virus replication
Conclusion: PLK1 is a proviral host factor that could be envisaged as a target for combined antiviral and antitumoral strategies against HBV infection and HBV‐mediated carcinogenesis. (Hepatology 2017).
Source: Hepatology - November 6, 2017 Category: Internal Medicine Authors: Ahmed Diab, Adrien Foca, Floriane Fusil, Thomas Lahlali, Pascal Jalaguier, Fouzia Amirache, Lia N'Guyen, Nathalie Isorce, Fran çois‐Loïc Cosset, Fabien Zoulim, Ourania Andrisani, David Durantel Tags: Viral Hepatitis Source Type: research
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome
We describe a fatal case of pediatric systemic capillary leak (Clarkson’s disease) associated with a point mutation in p190BRhoGAP. Dermal microvascular endothelial cells (ECs) isolated from this patient form monolayers with similar levels and distribution of junctional proteins and transendothelial electrical resistance compared with normal human dermal microvascular ECs. However, patient-derived ECs demonstrate a greater increase in permeability and impaired recovery of barrier function in response to tumor necrosis factor (TNF) compared with normal donor EC cultures. TNF transiently activates RhoB in ECs coinciden...
Source: The Journal of Experimental Medicine - November 29, 2017 Category: Internal Medicine Authors: Pierce, R. W., Merola, J., Lavik, J. P., Kluger, M. S., Huttner, A., Khokha, M. K., Pober, J. S. Tags: Cardiovascular Biology, Innate Immunity and Inflammation, Human Disease Genetics Brief Definitive Reports Source Type: research
Bile acids stimulate cholangiocyte fluid secretion by activation of membraneTMEM16A Cl ‐ channels
Conclusion: Bile acids stimulate Cl‐ secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca2+]i. These studies suggest that TMEM16A channels may be targets to increase bile flow during cholestasis. This article is protected by copyright. All rights reserved.
Source: Hepatology - January 23, 2018 Category: Internal Medicine Authors: Qin Li, Amal Dutta, Charles Kresge, Abhijit Bugde, Andrew P. Feranchak Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Long noncoding RNA hypoxia-inducible factor 1 alpha-antisense RNA 1 promotes tumor necrosis factor-α-induced apoptosis through caspase 3 in Kupffer cells
This study elucidates a new role of HIF1A-AS1 in TNF-α-induced cell apoptosis and provides potential therapeutic targets for ACLF.
Source: Medicine - January 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Conclusion AATF drives NAFLD and hepatocarcinogenesis, offering a potential target for therapeutic intervention.This article is protected by copyright. All rights reserved.
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Divya P. Kumar,
Prasanna K. Santhekadur,
Mulugeta Seneshaw,
Faridoddin Mirshahi,
Cora Uram Tuculescu,
Arun J. Sanyal Tags: Original Article Source Type: research
Calcineurin B1 subunit in human peripheral blood mononuclear cells and its role in idiopathic membranous nephropathy
The immune responses involved in the pathogenesis of idiopathic membranous nephropathy (IMN) have not been fully understood. Calcineurin, a key signaling enzyme in T-cell activation, may be implicated in IMN. The present study aimed to investigate the role of calcineurin B1 subunit (CnB1) in IMN and the potential mechanism.
A total of 59 biopsy-proven IMN patients and 28 healthy controls were recruited. The CnB1 expression in human peripheral blood mononuclear cells (PBMCs) was assessed by Western blotting. Knockdown and overexpression of CnB1 in Jurkat T cell line were achieved by small interference RNA (siRNA) transfect...
Source: Medicine - April 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma.
CONCLUSIONS: Heat stress induced protective autophagy against heat-induced apoptosis in HCC via the ATP-AMPK-mTOR axis, suggesting that targeting autophagy may be a promising strategy for improving the efficacy of RFA treatment for HCC.
PMID: 31007109 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - April 24, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Declined placental PLAC1 expression is involved in preeclampsia
This study aimed to clarify the change of the expression of placenta-specific 1 (PLAC1) in the placenta of preeclamptic women and to explore the regulatory effects on thophoblast by PLAC1.
Methods:
Nineteen women with preeclampsia and 19 with normal pregnancies were recruited, and then we determined the expression of PLAC1 by immunohistochemistry (IHC) and Western blotting. To observe the effect of hypoxia on the expression of PLAC1, trophoblasts were cultured at the normoxia or hypoxia condition. Small interference of ribonucleic acid (siRNA) was used to silence PLAC1. The proliferation, migration and invasion of troph...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Activin B signaling may promote the conversion of normal fibroblasts to scar fibroblasts
This study is to explore the molecular mechanism of benign bile duct hypertrophic scar formation.
Differential proteins between the normal fibroblast (NFB) and scar fibroblast (SCFB) were screened by protein chip assay, and analyzed by pathway-enrichment analysis and function-enrichment analysis. The differential proteins were further tested by ELISA. SiRNA-Act B was transfected to SCFB to down-regulate the expression of Act B. NFB was incubated with rh-Act B. The cell apoptosis and cell cycle were determined by flow cytometry. The expression of Act B, Smad2/3, transforming growth factor-β1 (TGF-β1), endothelin-1 (ET-1)...
Source: Medicine - June 12, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
