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Specialty: General Medicine

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Total 380 results found since Jan 2013.

Insulin growth factor-1 promotes the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells through the Wnt/ β-catenin pathway
Exp Ther Med. 2021 Aug;22(2):891. doi: 10.3892/etm.2021.10323. Epub 2021 Jun 17.ABSTRACTBone marrow mesenchymal stem cells (BMSCs) are stem cells that exist in bone marrow tissue and have osteogenic differentiation potential. Insulin growth factor-1 (IGF-1) plays a key role in the proliferation and osteogenic differentiation of BMSCs. However, the specific mechanism of IGF-1 in cell proliferation and osteogenic differentiation remains unclear. In the present study, BMSCs were transfected with lentivirus carrying the siRNA-Wnt3a gene, and the Wnt3a level in BMSCs was revealed to be reduced by western blotting, real-time qua...
Source: Experimental and Therapeutic Medicine - July 1, 2021 Category: General Medicine Authors: Jing Feng Zhiqiang Meng Source Type: research

CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
ConclusionCCT6A facilitates ESCC malignant activities by activating the TGF- β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.
Source: Irish Journal of Medical Science - April 5, 2023 Category: General Medicine Source Type: research

The dual role of tetraspanin CD63 in HIV-1 replication
Conclusions: Collectively, these findings indicate that CD63 may support Env-mediated fusion as well as a late (post-integration) step in the HIV-1 replication cycle.
Source: BioMed Central - February 8, 2014 Category: Journals (General) Authors: Guangyu LiMark A EndsleyAnoma SomasunderamSonia L GbotaMaryann I MbakaJames L MurrayMonique R Ferguson Source Type: research

Saturated Fatty Acid Induces Insulin Resistance Partially Through Nucleotide-binding Oligomerization Domain 1 Signaling Pathway in Adipocytes
Conclusion NOD1 might play an important role in saturated fatty acid-induced insulin resistance in adipocytes, suggesting a mechanism by which reduced NOD1 activity confers beneficial effects on insulin action.
Source: Chinese Medical Sciences Journal - November 1, 2014 Category: Journals (General) Source Type: research

Progress of Targeting Transforming Growth Factor-β1 Small Interfering RNA in Liver Fibrosis
Publication date: December 2014 Source:Chinese Medical Sciences Journal, Volume 29, Issue 4 Author(s): Xuan Zhou , Xue-feng Yang Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells (HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix (ECM). Transforming growth factor-beta (TGF-β), whi...
Source: Chinese Medical Sciences Journal - December 5, 2014 Category: Journals (General) Source Type: research

Effect of pERK2 on extracellular matrix turnover of the fibrotic joint capsule in a post-traumatic joint contracture model.
Authors: Sun Y, Li F, Fan C Abstract Lentivirus (LV)-mediated extracellular signal-regulated kinase (ERK)2 small interfering RNA (siRNA) has previously been demonstrated to reduce post-traumatic joint contractures: In the present study, the effect of ERK2 siRNA on extracellular matrix turnover within fibrotic joint capsules in post-traumatic joint contractures was examined. Rats were randomly assigned to one of three groups as follows: The non-operated control (CON), operated contracture (ORC) and contracture-treatment (CNT) groups. Representative post-traumatic joint contracture was created through 8 weeks of immo...
Source: Experimental and Therapeutic Medicine - February 21, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Expression of pituitary tumor-transforming 2 in human glioblastoma cell lines and its role in glioblastoma tumorigenesis.
Authors: Guo Y, Shao Y, Chen J, Xu S, Zhang X, Liu H Abstract The present study aimed to investigate the association between the expression of pituitary tumor-transforming 2 (PTTG2), and cell proliferation, invasion and apoptosis in glioblastoma. The U251 human glioblastoma cell line was transfected with the pcDNA-PTTG2 and small interfering (si)RNA-PTTG2 plasmids using Lipofectamine 2000. The expression of PTTG2 in U251 glioblastoma cells was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. The association between PTTG2 expression, and cell prolifer...
Source: Experimental and Therapeutic Medicine - May 16, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study.
In this study, the effects of small interfering RNA (siRNA)-mediated silencing of NAMPT and LYST on cell proliferation and apoptosis were evaluated in RPMI 8226 myeloma cells. Transfection efficiencies were determined by quantitative real time reverse transcriptase PCR. Cell proliferation was determined using MTT assay, while apoptosis was analyzed with flow cytometry using Annexin V-fluorescein isothiocyanate/propidium iodide assay. The NAMPT protein expression in siRNA-treated cells was estimated by enzyme-linked immunosorbent assay. Our results showed that NAMPT and LYST were successfully knockdown by siRNA transfection...
Source: Bosnian Journal of Basic Medical Sciences - October 20, 2016 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research