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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules
Zygote. 2021 May 26:1-12. doi: 10.1017/S0967199421000344. Online ahead of print.ABSTRACTMicrotubule-severing protein (MTSP) is critical for the survival of both mitotic and postmitotic cells. However, the study of MTSP during meiosis of mammalian oocytes has not been reported. We found that spastin, a member of the MTSP family, was highly expressed in oocytes and aggregated in spindle microtubules. After knocking down spastin by specific siRNA, the spindle microtubule density of meiotic oocytes decreased significantly. When the oocytes were cultured in vitro, the oocytes lacking spastin showed an obvious maturation disorde...
Source: Zygote - May 26, 2021 Category: Reproduction Medicine Authors: Zhen Jin Hua-Feng Shou Jin-Wei Liu Shan-Shan Jiang Yan Shen Wei-Ye Cheng Lei-Lei Gao Source Type: research

Downregulation of decidual SKP2 is associated with human recurrent miscarriage
CONCLUSIONS: Our study indicates a functional role of SKP2 in RM: downregulation of SKP2 in RM leads to impaired decidualization and downregulation of GLUT1 and consequently predisposes individuals to RM.PMID:34116705 | DOI:10.1186/s12958-021-00775-4
Source: Reproductive Biology - June 12, 2021 Category: Reproduction Medicine Authors: Shijian Lv Mei Liu Lizhen Xu Cong Zhang Source Type: research

The IL6/sIL-6R α trans-signaling increases PGE2 production in human granulosa cells
In conclusion, IL6 trans-signaling upregulates the expression of PTGS2 and increases the production of PGE2 via the JAK2/STAT3/SOCS3 signaling pathway in hGL cells. Our findings provide insights into the molecular mechanisms by which IL6 trans-signaling may potentially modulate the event of ovulation in human ovaries.PMID:34198336 | DOI:10.1093/biolre/ioab128
Source: Biology of Reproduction - July 1, 2021 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jiamin Xie Jeremy H Wang Jing Yang Peter C K Leung Source Type: research

Overexpressed MPS-1 contributes to endometrioma development through the NF- κB signaling pathway
CONCLUSION: MPS-1 can regulate EcESCs proliferation, motility, invasion, apoptosis, and cell cycle via the NF-κB signaling pathway in endometrioma. This may contribute to the formation or development of endometriotic foci. This study suggests the potential role of MPS-1 in the pathogenesis of endometriosis and enabled further research into the use of MPS-1 in the clinical diagnosis of endometrioma.PMID:34266426 | DOI:10.1186/s12958-021-00796-z
Source: Reproductive Biology - July 16, 2021 Category: Reproduction Medicine Authors: Yang Liu Junyan Ma Liqi Zhang Jun Lin Xiaohua Liu Source Type: research

P –556 NAT10-mediated N4-acetylcytidine in RNA regulates mouse oocyte maturation in vitro
This study was performed in vitro. The role of NAT10-mediated ac4C in vivo remains to be elucidated. Also, limited by current techniques, ac4C modification in oocytes cannot be detected. Our exploration of regulated genes and ac4C binding proteins were performed in somatic cell lines.Wider implications of the findings: Post-transcriptional modulation is crucial in oocyte maturation. Our study using in-vitro systems for mouse oocyte identified NAT10-mediated ac4C as an important regulator in IVM. It provided a new insight into the epigenetic mechanisms of IVM, which may lead to improvement of clinical IVM systems.Trial regi...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

O-145 Green Tea catechins EGCG and pro-drug of EGCG (Pro-EGCG) inhibit endometriosis through targeting molecules regulating macrophages and B cells
This study shows that macrophage and B cell could be potential therapeutic targets for treatment of endometriosis, which opens up new horizon for the novel immunotherapy for endometriosis.Trial registration numberNA
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

P-556 Pre-selected for an award: NAT10-mediated N4-acetylcytidine in RNA regulates mouse oocyte maturation in vitro
This study was performed in vitro. The role of NAT10-mediated ac4C in vivo remains to be elucidated. Also, limited by current techniques, ac4C modification in oocytes cannot be detected. Our exploration of regulated genes and ac4C binding proteins were performed in somatic cell lines.Wider implications of the findingsPost-transcriptional modulation is crucial in oocyte maturation. Our study using in-vitro systems for mouse oocyte identified NAT10-mediated ac4C as an important regulator in IVM. It provided a new insight into the epigenetic mechanisms of IVM, which may lead to improvement of clinical IVM systems.Trial regist...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research