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Vaccination: Malaria Vaccine
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Total 1496 results found since Jan 2013.
An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge
Vaccines (Basel). 2022 Feb 16;10(2):300. doi: 10.3390/vaccines10020300.ABSTRACTHere, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this mala...
Source: Herpes - February 26, 2022 Category: Infectious Diseases Authors: Paul J F Rider Mohd Kamil Ilknur Yilmaz Habibe N Atmaca Merve Kalkan-Yazici Mehmet Ziya Doymaz Konstantin G Kousoulas Ahmed S I Aly Source Type: research
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review
Rev Inst Med Trop Sao Paulo. 2022 Mar 11;64:e23. doi: 10.1590/S1678-9946202264023. eCollection 2022.ABSTRACTDespite the many efforts of researchers around the world, there is currently no effective vaccine for malaria. Numerous studies have been developed to find vaccine antigens that are immunogenic and safe. Among antigen candidates, Plasmodium falciparum merozoite surface protein 3 (MSP3) has stood out in a number of these studies for its ability to induce a consistent and protective immune response, also being safe for use in humans. This review presents the main studies that explored MSP3 as a vaccine candidate over t...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 16, 2022 Category: Tropical Medicine Authors: K éssia Caroline Souza Alves Jander Matos Guimar ães Maria Edilene Martins de Almeida Lu ís André Morais Mariúba Source Type: research
Synthesis, spectral characterization, crystal structure and computational investigation of 2-formyl-6-methoxy-3-carbethoxy quinoline as potential SARS-CoV inhibitor
J Phys Chem Solids. 2022 Nov;170:110886. doi: 10.1016/j.jpcs.2022.110886. Epub 2022 Jul 12.ABSTRACTThe recent COVID-19 outbreak caused by the novel coronavirus SARS-CoV-2 has an immense impact on global health and economy. Although vaccines are being used, urgent need of drugs based on natural products with high efficacy and safety is a pressing priority. Quinoline alkaloids are well known for their therapeutic action against malaria; initially, it was tried against Coronaviruses. It is a basic vital scaffold to design drugs with required biological and pharmacological activities. In this present study, a new quinoline com...
Source: Health Physics - July 18, 2022 Category: Physics Authors: A Franklin Ebenazer M Saravanabhavan K S Ramesh Shabbir Muhammad Abdullah G Al-Sehemi N Sampathkumar Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | PMC:PMC9209925 | DOI:10.4269/ajtmh.22-0073
Source: Am J Trop Med Hyg - July 27, 2022 Category: Infectious Diseases Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
