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Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses
In conclusion, our study indicated that 3 weeks antibiotic administration induced elevated expression of many cytokines in mouse colon, suggesting that there might be a direct interaction between antibiotics and host tissue. Furthermore, different antibiotics used can lead to different effects on mouse models. Broad spectrum antibiotic enrofloxacin had a stronger effect on the cytokines response in the colon. Vancomycin can induce significant changes in composition and metabolic profiling of gut microbiota. Compared to enrofloxacin and vancomycin, polymixin B sulfate had a weakest effect. The differences observed in compos...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome
This study was carried out after written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Stanford University and UCLA Institutional Review Boards. Author Contributions MB provided patient care and obtained IRB approval. RO prepared histology images. MB, TT, and RB designed the research. TT and LP conducted experiments and analyzed data. MB made the molecular model. MB and TT wrote the manuscript. Funding Funding for this work came from the Jeffrey Modell Foundation and from the NIH/NIGMS (R01 GM110482 to MB)....
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Title: The WASH Approach: Fighting Waterborne Disease in Emergency Situations
Refugees collect water from a public tap stand in an Adjumani settlement. © Wendee Nicole Rhino Camp, Arua District. Refugees in Uganda live on land donated by Ugandan nationals. Refugee families are given plots on which they can build temporary shelters and grow crops.© Wendee Nicole Oxfam staff members Tim Sutton (left) and Pius Nzuki Kitonyi (right) with the soon-to-be-repaired water pump in Adjumani. In disaster-affected situations, Oxfam takes a lead in delivering WASH-related services.© Wendee Nicole Hand-operated water pumps are a reliable source of pre...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Community Health Disaster Response Drinking Water Quality Infectious Disease Infrastructure International Environmental Health Microbial Agents Sanitation Warfare and Aftermath Water Pollution Source Type: research