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Specialty: Respiratory Medicine
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Total 35 results found since Jan 2013.

Detection of structural airway changes on computed tomography in paediatric severe asthma
Conclusion: Bronchiectasis and airway wall thickening is frequently observed on CTs of children with SA. SAD is related to airway wall thickening.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: van den Bosch, W., Lv, Q., Andrinopoulou, E., Janssens, H., Ciet, P., Tiddens, H. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

Association between Staphylococcal Enterotoxin (SE)-specific IgE and specific IgE for house dust mites (HDM) in Brazilian patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
SE are a group of superantigens formerly associated with several respiratory diseases, including asthma, rhinitis and CRSwNP. Superantigens trigger the production of high specific IgE levels and are usually related to high levels of total IgE (tIgE) and eosinophilic inflammation.We aim to evaluate the correlation between the positivity of SE-specific IgE for A; B; C; TSST-1; tIgE and specific IgE for D. pteronyssinus (DP); D. farinae (DF) and B. tropicalis (BT) in CRSwNP Brazilian patients.36 CSRwNP patients, defined by 2012-EPOS (European Position Paper on Rhinosinusitis) criteria, submitted to nasal endoscopy and CT...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Campos Dos Santos, P., Dortas Junior, S., Elabras Filho, J., Da Cruz, F., Valle, S., Ferraiolo, P. Tags: 05.03 - Allergy and immunology Source Type: research

Cough Presentation and Cough-Related Healthcare Utilization in Tertiary Care: Analysis of Routinely Collected Academic Institutional Database
ConclusionsCough is a common chief complaint at allergy and asthma clinics, but the clinical presentation may be heterogeneous. Further studies are needed to understand long-term outcomes and reduce the disease burden.
Source: Lung - July 9, 2022 Category: Respiratory Medicine Source Type: research

Is asthma a risk factor for severe outcomes in COVID 19?
Conclusion: Our study shows that the prevalence of asthma among covid-19 patients is similar to the prevalence in the general population, asthmatic patients are not more prone than others to catching the virus and asthma is not a risk factor for severe outcomes.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Saidani, A., Maddeh, S., Kallel, N., Moussa, N., Gargouri, R., Kotti, A., Bahloul, N., Fki, W., Kammoun, S. Tags: Allergy and immunology Source Type: research

Computed tomography (CT) in children with long-term synonasal symptoms (SNS)
Conclusions: Thus, 66.7% of pediatric and adolescent patients with prolonged SNS had CT signs of cystic, cystic-polyposis, and polyposis SM changes. These changes, in our opinion, should be considered in the aspect of the onset of CRS formation with or without polyps in children and adolescents.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Gluhova, M., Eruslankin, N., Grachev, K., Ignatov, G., Krasilnikova, S., Eliseeva, T., Bulgakova, V., Klimanov, I., Popova, N. Tags: Paediatric asthma and allergy Source Type: research

Asthma-COPD overlap: current understanding and the utility of experimental models
Pathological features of both asthma and COPD coexist in some patients and this is termed asthma-COPD overlap (ACO). ACO is heterogeneous and patients exhibit various combinations of asthma and COPD features, making it difficult to characterise the underlying pathogenic mechanisms. There are no controlled studies that define effective therapies for ACO, which arises from the lack of international consensus on the definition and diagnostic criteria for ACO, as well as scant in vitro and in vivo data. There remain unmet needs for experimental models of ACO that accurately recapitulate the hallmark features of ACO in patients...
Source: European Respiratory Review - February 16, 2021 Category: Respiratory Medicine Authors: Tu, X., Donovan, C., Kim, R. Y., Wark, P. A. B., Horvat, J. C., Hansbro, P. M. Tags: COPD and smoking, Asthma and allergy Reviews Source Type: research

Development and characterisation of a multi-species COPD biofilm
This study highlights the need to utilise multi-species biofilms to study the pathogenesis of disease and emphasises the importance of selecting appropriate antimicrobial therapies.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Short, B., Williams, C., Litherland, G., Lundy, F., Mackay, W., Ramage, G. Tags: Allergy and immunology Source Type: research

Effect of mepolizumab on chronic rhinosinusitis symptoms and nasal hypersensitivity in patients with or without nasal polyps
Conclusions: In SEA patients with CRSwNP a positive effect in reducing symptoms, nasal hypersensitivity and NP was seen however, a larger number of patients is needed in order to have conclusive results
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Rovina, N., Tsami, M., Panagiotou, M., Syrigou, E., Koulouris, N. Tags: Allergy and immunology Source Type: research

Minimal clinically important difference for asthma endpoints: an expert consensus report
Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and would lead to a change in the patient's medical management. The aim of the current expert consensus report is to provide a "state-of-the-art" review of the currently available literature evidence about MCID for end-points to monitor asthma control, in order to facilitate optimal disease management and identify unmet needs in the field to guide future research. A series of MCID cut-offs are currently available in literature and validated among populations of asthmatic p...
Source: European Respiratory Review - June 2, 2020 Category: Respiratory Medicine Authors: Bonini, M., Di Paolo, M., Bagnasco, D., Baiardini, I., Braido, F., Caminati, M., Carpagnano, E., Contoli, M., Corsico, A., Del Giacco, S., Heffler, E., Lombardi, C., Menichini, I., Milanese, M., Scichilone, N., Senna, G., Canonica, G. W. Tags: Asthma and allergy Reviews Source Type: research

Pneumocystis jiroveci.
Abstract Pneumocystis jiroveci remains an important fungal pathogen in a broad range of immunocompromised hosts. The natural reservoir of infection remains unknown. Pneumocystis jiroveci Pneumonia (PJP) develops via airborne transmission or reactivation of inadequately treated infection. Nosocomial clusters of infection have been described among immunocompromised hosts. Subclinical infection or colonization may occur. Pneumocystis pneumonia occurs most often within 6 months of organ transplantation and with intensified or prolonged immunosuppression, notably with corticosteroids. Infection is also common during ne...
Source: Respiratory Care - January 31, 2020 Category: Respiratory Medicine Authors: Fishman JA Tags: Semin Respir Crit Care Med Source Type: research

Pneumocystis jiroveci
Semin Respir Crit Care Med 2020; 41: 141-157 DOI: 10.1055/s-0039-3399559 Pneumocystis jiroveci remains an important fungal pathogen in a broad range of immunocompromised hosts. The natural reservoir of infection remains unknown. Pneumocystis jiroveci Pneumonia (PJP) develops via airborne transmission or reactivation of inadequately treated infection. Nosocomial clusters of infection have been described among immunocompromised hosts. Subclinical infection or colonization may occur. Pneumocystis pneumonia occurs most often within 6 months of organ transplantation and with intensified or prolonged immunosuppression, notabl...
Source: Seminars in Respiratory and Critical Care Medicine - January 29, 2020 Category: Respiratory Medicine Authors: Fishman, Jay A. Tags: Review Article Source Type: research

Cross-reactive carbohydrate determinant (CCD) inhibition test can help identify false positive for plant allergen sIgE caused by CCD
Conclusion: More than 73% plant allergens-sIgE were eliminated into negative after CCD inhibition experiment, suggesting majority the plant allergic patients in southern China. CCD inhibition test should be used in clinical diagnosis, which can help to avoid misdiagnosis of plant allergens.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Luo, W., Sun, B. Tags: Allergy and immunology Source Type: research

Elevated serum IgE, oral corticosteroid dependence and IL-17/22 expression in highly neutrophilic asthma
Information on the clinical traits associated with bronchial neutrophilia in asthma is scant, preventing its recognition and adequate treatment. We aimed to assess the clinical, functional and biological features of neutrophilic asthma and identify possible predictors of bronchial neutrophilia. The inflammatory phenotype of 70 mild-to-severe asthma patients was studied cross-sectionally based on the eosinophilic/neutrophilic counts in their bronchial lamina propria. Patients were classified as neutrophilic or non-neutrophilic. Neutrophilic asthma patients (neutrophil count cut-off: 47.17 neutrophils·mm–2;...
Source: European Respiratory Journal - November 6, 2019 Category: Respiratory Medicine Authors: Bullone, M., Carriero, V., Bertolini, F., Folino, A., Mannelli, A., Di Stefano, A., Gnemmi, I., Torchio, R., Ricciardolo, F. L. M. Tags: Lung biology and experimental studies, Asthma and allergy Original Articles: Asthma and basic science Source Type: research

The use of magnetic resonance imaging in differential diagnosis of allergic fungal sinusitis and eosinophilic mucin rhinosinusitis.
Conclusions: MRI features are key to the differential diagnosis of AFS and EMRS. PMID: 31559063 [PubMed]
Source: Journal of Thoracic Disease - September 28, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research