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Triggers of Anaphylaxis in Mastocytosis Patients: Evidence of the Current Drug-Avoidance Recommendation
Opinion statementMastocytosis is associated with a high risk of anaphylaxis, in part due to drug hypersensitivity reactions (DHR). Drugs associated with mast cell activation include nonsteroidal anti-inflammatory drugs (NSAIDs), drugs used in the perioperative setting, including general anesthetics, neuromuscular blocking agents (NMBAs) and opiates/opioids, radiocontrast media (RCM), vaccines, and antibiotics such as quinolones and vancomycin. To protect patients against DHR and anaphylaxis, general avoidance of potential drug triggers is common practice, which often deprives patients of important drugs at times of need an...
Source: Current Treatment Options in Allergy - September 20, 2023 Category: Allergy & Immunology Source Type: research

What is Ondine ’ s Curse?
Discussion Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome. Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

With All Eyes on BA.2, Here ’s What Experts Say Might Happen in the U.S.
For the last two years, the U.S. has been stuck in a cycle of COVID-19 case spikes and lulls. Cases rise dramatically, then drop off—and the process repeats. Several times, these surges have been preceded by rising case rates in Europe—such as before last year’s Delta wave and the start of last winter’s Omicron spike—which is why experts have been carefully monitoring a recent increase in cases there. More than 5.2 million COVID-19 infections were reported across Europe during the week ending March 20, according to World Health Organization data, and countries including the U.K. have also repo...
Source: TIME: Health - March 25, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

With All Eyes on BA.2, Here ’ s What Experts Say Might Happen in the U.S.
For the last two years, the U.S. has been stuck in a cycle of COVID-19 case spikes and lulls. Cases rise dramatically, then drop off—and the process repeats. Several times, these surges have been preceded by rising case rates in Europe—such as before last year’s Delta wave and the start of last winter’s Omicron spike—which is why experts have been carefully monitoring a recent increase in cases there. More than 5.2 million COVID-19 infections were reported across Europe during the week ending March 20, according to World Health Organization data, and countries including the U.K. have also repo...
Source: TIME: Health - March 25, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

Too Many Americans Still Mistrust the COVID-19 Vaccines. Here ’s Why
If you’re feeling impatient waiting your turn for a COVID-19 vaccine, here’s a little good news: Angela Padgett will gladly give you her place in line—at least for now. Padgett, president of a day spa in Raleigh, N.C., is under no illusions about the mortal danger the pandemic poses to herself, her family and the world writ large—indeed, she had COVID-19 back in July. But as for the vaccine that is supposed to put an end to all of the suffering at last? Not today. “I am a little bit hesitant,” she says. “I can appreciate President Trump trying to get this moving fast and I’ve...
Source: TIME: Health - January 5, 2021 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized COVID-19 Source Type: news

Th2-TRMs Maintain Life-Long Allergic Memory in Experimental Asthma in Mice
This study was carried out in strict accordance with the guidelines for the care and use of laboratory animals of the Austrian Ministry of Science. The protocol was approved by the Committee on the Ethics of the Austrian Ministry of Science (Number: GZ: 66.009/0330-II/3b/2013). All painful procedures were performed under anesthesia, and all efforts were made to minimize suffering. Author Contributions BB designed and performed experiments, analyzed the samples and contributed to the manuscript preparation. SK designed and performed experiments, analyzed the samples and contributed to the manuscript preparation. LA perfor...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
This study was also partly funded by a research contract from GSK. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the funders. Conflict of Interest Statement AG-S, FK, and PP are inventors in patent applications filed and owned b
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Spoonful of Sugar Alone May Not Ease Babies ' Vaccination Pain Spoonful of Sugar Alone May Not Ease Babies ' Vaccination Pain
The best way to ease babies ' pain during vaccinations may be to give them a sip of sugar and rub anesthetic cream on the injection site before they get shots, a recent experiment suggests.Reuters Health Information
Source: Medscape Allergy Headlines - December 13, 2016 Category: Allergy & Immunology Tags: Pediatrics News Source Type: news

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

What Are Risk Factors for Latex Allergy?
Discussion Latex comes from the Hevea brasiliensis plants. There are multiple potentially allergenic polypeptides within the plant’s fluid called Heb b 1-13. True sensitizers are Heb b 1, 5 and 6. Heb b 8 and 12 are cross-reacting proteins. The type of the latex product and how it is prepared makes a difference in exposure to the latex allergens. Certain extruded latex products such as catheters and rubber stoppers have higher concentrations of true sensitizer allergens. Products made from molds such as gloves have higher concentrations of potential allergens than latex made in sheets such as such as dental dams. Use...
Source: PediatricEducation.org - February 1, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Question 2: Does topical local anaesthetic reduce pain from vaccinations in infants?
Scenario You are about to give a 2-month-old baby her first vaccinations. You wonder if there is a role for topical local anaesthetics in reducing pain from intramuscular injection of vaccinations. Structured clinical question In an infant undergoing intramuscular vaccination injection (patient) does topical local anaesthetic (intervention) compared with placebo (control) reduce pain (outcome). Search Secondary sources—nil. Search MEDLINE: (intramuscular OR vacc* OR immuni*) AND ("local anaesthetic" OR EMLA OR Ametop OR tetracaine OR amethocaine OR eutectic) more than 90 results. Five studies excluded as patients wer...
Source: Archives of Disease in Childhood - October 12, 2014 Category: Pediatrics Authors: Levene, I. Tags: ADC Archimedes, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Pain (neurology), Pain (palliative care), Pain (anaesthesia) Source Type: research

Severe drug‐induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010
ConclusionsThree hundred and thirty‐three case reports provided data on drugs involved in severe anaphylaxis. The efficacy of skin tests and poor use of laboratory tests are underlined. Further progress may depend on OCs.
Source: Allergy - June 6, 2013 Category: Allergy & Immunology Authors: J.‐M. Renaudin, E. Beaudouin, C. Ponvert, P. Demoly, D.‐A. Moneret‐Vautrin Tags: Original Article Source Type: research