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Total 443 results found since Jan 2013.

Minimally invasive arthrodesis of the sacroiliac joint (SIJ)
Oper Orthop Traumatol. 2021 Oct 18. doi: 10.1007/s00064-021-00738-3. Online ahead of print.ABSTRACTOBJECTIVE: Pain reduction and improvement in quality of life with sacroiliac joint (SIJ) fusion.INDICATIONS: Chronic SIJ-associated pain; positive response to SIJ injection with local anesthetic; positive SIJ provocation tests; failed conservative therapy over 6 months.CONTRAINDICATIONS: Non-SIJ-associated pain; tumor/infection/unstable fracture in the implantation area; malformations; tumor or osteolysis of the sacrum or ilium bone; active infection at the implantation site; allergy to metal components; secondary gain from i...
Source: Operative Orthopadie und Traumatologie - October 18, 2021 Category: Orthopaedics Authors: Adnan Kasapovic Thaer Ali Max Jaenisch Yorck Rommelspacher Martin Gathen Robert Pflugmacher Desire é Schwetje Source Type: research

Long ‐acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study
ConclusionsLYR-210 is the first implantable sinonasal treatment to achieve up to 24 weeks of benefit from a single administration in surgically naive CRS patients with and without nasal polyps.
Source: International Forum of Allergy and Rhinology - September 18, 2021 Category: Allergy & Immunology Authors: Anders Cervin, Joanne Rimmer, Agnieszka Wrobel, Yogen Abelak, Lindsay Brayton, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research

Janssen Presents Results of First Head-to-Head Study of Biologic Therapies in Patients with Moderate to Severe Crohn ’s Disease
SPRING HOUSE, PENNSYLVANIA, May 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced efficacy and safety data for STELARA® (ustekinumab) in Crohn’s disease (CD) and ulcerative colitis (UC),1-4including data from the SEAVUE study, the first head-to-head study of biologic therapies in patients with CD, presented in a Clinical Science Late-Breaking Abstract Plenary session.1 SEAVUE data showed treatment with STELARA demonstrated high rates of clinical remission, corticosteroid-free remission, clinical response and endoscopic response through one year in biologic-naïve patients with mo...
Source: Johnson and Johnson - May 24, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

What Are Risk Factors for Bronchopulmonary Dysplasia?
Discussion Bronchopulmonary dysplasia (BPD) was first described in 1967 by Northway et.al. At that time it was described as “relatively mature preterm infants with severe respiratory failure to survive their initial respiratory distress syndrome after receiving aggressive respiratory support with high oxygen and positive pressure ventilation. Their clinical course was characterized by severe chronic respiratory failure with a radiographic picture showing areas of hyperinflation alternating with adjacent increased densities.” This is often referred to as “Old BPD.” Over time more has been learned and...
Source: PediatricEducation.org - May 10, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Responsiveness and convergent validity of the chronic rhinosinusitis patient ‐reported outcome (CRS‐PRO) measure in CRS patients undergoing endoscopic sinus surgery
ConclusionThis study demonstrates the validity and responsiveness of the CRS ‐PRO in subjects receiving ESS.
Source: International Forum of Allergy and Rhinology - March 17, 2021 Category: Allergy & Immunology Authors: Katherine A. Lin, Caroline P.E. Price, Julia H. Huang, Saied Ghadersohi, David Cella, Robert C. Kern, David B. Conley, Stephanie Shintani ‐Smith, Kevin C. Welch, Bruce K. Tan Tags: ORIGINAL ARTICLE Source Type: research

A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature
AbstractPurpose of ReviewOchronosis and alkaptonuria are manifestations of the same condition —a rare autosomal recessive disorder resulting from a constitutional lack of homogentisate 1,2-dioxygenase (HGD) with the consequent accumulation of homogentisic acid (HGA). In ochronosis, HGA undergoes autoxidation as well as enzymatic oxidation to form an ochronotic pigment that accumulates in c artilage and connective tissues. In the beginning, there is homogentisic aciduria and pigmentation of cartilages and other connective tissues. In later years, generalized osteoarthritis of the spine and large joints, termed ochronotic ...
Source: Current Allergy and Asthma Reports - March 5, 2021 Category: Allergy & Immunology Source Type: research

Medical and surgical treatment outcomes in patients with chronic rhinosinusitis and immunodeficiency: a systematic review
ConclusionPatients with CRS and immunodeficiency likely benefit from ESS based on the available evidence. Data supporting medical therapy in this targeted population is limited overall, but there may be a potential role for immunoglobulin therapy in patients with PID and CRS.
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Shireen Samargandy, Elysia Grose, Yvonne Chan, Eric Monteiro, John M. Lee, Jonathan Yip Tags: ORIGINAL ARTICLE Source Type: research

Similar rates of return to sports and BMI reduction regardless of age, gender and preoperative BMI as seen in matched cohort of hypoallergenic and standard Cobalt Chromium medial unicompartmental knee arthroplasty
ConclusionsBoth TiNbN and CoCr medial mobile-bearing UKA enabled patients to return to sports after the final follow-up, regardless of age, BMI, gender and metal sensitivity. These findings inform shared decision making and can help to manage patient expectations after surgery, in particular, in active patients with an overt metal allergy, a specific hypoallergenic implant should be considered the gold standard implant in partial knee replacement surgery.Level of evidenceCohort Study, Level III.Registration: researchregistry6250 —www.researchregistry.com.
Source: Knee Surgery, Sports Traumatology, Arthroscopy - February 7, 2021 Category: Orthopaedics Source Type: research

Decrease in Antibiotic Use and Radiographic Sinus Severity after Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis and Antibody Immunodeficiencies
This study evaluates number of antibiotic courses for sino-pulmonary infections and radiographic sinus disease severity after FESS in patients with CRS and antibody immunodeficiencies.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Matthew Perez Source Type: research

Microbiology, Histopathology, and Radiographic Findings in Silent Sinus Syndrome.
CONCLUSION: These data support the hypothesis that the pathogenesis of SSS is more likely due to anatomical/mechanical factors than inflammatory/microbiological factors. PMID: 33463370 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - January 19, 2021 Category: ENT & OMF Authors: Zheng HD, Mecham JC, Abdel-Aty Y, Lal D, Marino MJ Tags: Am J Rhinol Allergy Source Type: research

Treatment of naturally occurring asthma with inhaled fluticasone or oral prednisolone: A randomized pilot trial
The objective of this study was to compare inhaled glucocorticoids with oral glucocorticoids for treatment of naturally occurring feline asthma. Secondary goals were to evaluate serum allergy testing results in cats and to quantify the effect of an inhaled glucocorticoid (fluticasone) on glucose homeostasis. Nine cats with asthma were enrolled on the basis of clinical signs, thoracic radiographic findings, and airway eosinophilia. Cats were randomized and 4 cats were treated with oral glucocorticoids and 5 cats with inhaled glucocorticoids, with a 7-day course of oral glucocorticoids overlapping at the start of therapy. Ca...
Source: Canadian Journal of Veterinary Research - January 4, 2021 Category: Veterinary Research Authors: Michael Verschoor-Kirss Elizabeth A Rozanski Claire R Sharp Trisha J Oura Ashley Egan Perry Bain Joyce Knoll Source Type: research