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What Are Causes of Childhood Interstital Lung Disease?
Discussion Interstitial lung disease in children (chILD) is less understood than adult interstitial lung disease (ILD) and is rare. Prevalence is ~ 0.13 to 16.2 per 100,000 children under age 17 years. chILD is an general term for respiratory disorders that are heterogeneous, chronic and impair lung function. While some define diffuse parenchymal lung disease (DPLD) separately, the term ILD usually encompases DPLD. chILD has variable definitions and is “usually diagnosed if three of the following features are present: 1) respiratory symptoms (cough, rapid and/or difficult breathing, and exercise intolerance), 2) res...
Source: PediatricEducation.org - August 1, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

UCLA awarded $11.5 million to improve organ, hand and face transplantation
The Dumont –UCLA Transplant Center has received two grants totaling $11.5 million from the federal government for research aimed at making donated organs last longer and helping transplant recipients live longer, healthier lives.The grant projects — one funded by the National Institutes of Health and the other by the Department of Defense — focus specifically on improving outcomes in liver transplantation and in hand and face transplantation.Both initiatives are led by Dr. Jerzy Kupiec-Weglinski, UCLA ’s Paul I. Terasaki Professor of Surgery and vice chair of basic research in the surgery department at theDavid Gef...
Source: UCLA Newsroom: Health Sciences - July 29, 2022 Category: Universities & Medical Training Source Type: news

Mycophenolate Mofetil Use Is Associated With Reduced Incidence of Food Allergy in Liver Transplanted Children
Conclusions: Use of MMF 1 and 2 years after transplantation was associated with less food allergy and sensitization against food allergens. The effect of MMF was not due to reduced trough levels of tacrolimus.
Source: Journal of Pediatric Gastroenterology and Nutrition - July 28, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Quadruplet Tx in Myeloma May Reduce Need for Transplants Quadruplet Tx in Myeloma May Reduce Need for Transplants
Novel quadruplet combinations are transforming therapy in multiple melanoma and pointing towards a reduced need for stem cell transplants.Medscape Medical News
Source: Medscape Allergy Headlines - July 27, 2022 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

Confirmation of Hyperimmunoglobulin E Syndrome in Two Patients with an Ocular Problem: Detection of Two New DOCK8 Mutations
This study aimed to confirm the diagnosis of two cases of autosomal recessive hyper-immunoglobulin E (IgE) syndrome (AR-HIES), presenting with irreversible eye involvement. Two unrelated patients with suspected AR-HIES were referred to the Immunology, Asthma and Allergy Research Institute (IAARI), Tehran, Iran. Immunological screening tests were performed for AR-HIES, which showed elevated serum IgE levels, eosinophilia, and low T-lymphocyte responses. NGS was performed, and the results were confirmed by Sanger sequencing. Sequence analysis showed a mutation in intron 17 of the dedicator of cytokinesis 8 (DOCK8) gene in th...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Shiva Saghafi Fariborz Zandieh Mohammad Reza Fazlollahi Cristina Glocker Natalie Frede Mary Buchta Linlin Yang Amir Hossein Mahmoudi Massoud Houshmand Zahra Pourpak Bodo Grimbacher Mostafa Moin Source Type: research

Transient acquired donor peanut allergy presenting as life-threatening anaphylaxis following lung transplantation
Ann Allergy Asthma Immunol. 2022 Jul 10:S1081-1206(22)00583-X. doi: 10.1016/j.anai.2022.06.029. Online ahead of print.NO ABSTRACTPMID:35830945 | DOI:10.1016/j.anai.2022.06.029
Source: Annals of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Stephanie Stojanovic Josh Chatelier Julian Bosco Robyn E O'Hehir Greg Snell Source Type: research

Confirmation of Hyperimmunoglobulin E Syndrome in Two Patients with an Ocular Problem: Detection of Two New DOCK8 Mutations
This study aimed to confirm the diagnosis of two cases of autosomal recessive hyper-immunoglobulin E (IgE) syndrome (AR-HIES), presenting with irreversible eye involvement. Two unrelated patients with suspected AR-HIES were referred to the Immunology, Asthma and Allergy Research Institute (IAARI), Tehran, Iran. Immunological screening tests were performed for AR-HIES, which showed elevated serum IgE levels, eosinophilia, and low T-lymphocyte responses. NGS was performed, and the results were confirmed by Sanger sequencing. Sequence analysis showed a mutation in intron 17 of the dedicator of cytokinesis 8 (DOCK8) gene in th...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Shiva Saghafi Fariborz Zandieh Mohammad Reza Fazlollahi Cristina Glocker Natalie Frede Mary Buchta Linlin Yang Amir Hossein Mahmoudi Massoud Houshmand Zahra Pourpak Bodo Grimbacher Mostafa Moin Source Type: research