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Vaccination: Meningitis Vaccine

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Total 126 results found since Jan 2013.

Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy
Transient hypogammaglobulinemia of infancy (THI) is a primary antibody deficiency occurring in the first years of life and is characterized by a delay in the immunoglobulin production that spontaneously recovers in early infancy. In the young symptomatic child with low IgG levels and more than 2% B cells, there are no peculiar clinical and immunologic features that allow discrimination between self-limiting THI, common variable immunodeficiency, or other dysgammaglobulinemias. Only those patients whose IgG levels have normalized after age 4 years have a definitive THI diagnosis made a posteriori.
Source: Journal of Allergy and Clinical Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Viviana Moschese, Filomena Monica Cavaliere, Simona Graziani, Caterina Bilotta, Cinzia Milito, Loredana Chini, Isabella Quinti Tags: Letter to the Editor Source Type: research

Specific Antibody Deficiencies
Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptom...
Source: Immunology and Allergy Clinics of North America - August 25, 2015 Category: Allergy & Immunology Authors: Luke A. Wall, Victoria R. Dimitriades, Ricardo U. Sorensen Source Type: research

The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children
This report provides final follow-up data for a large phase III trial conducted at 11 sites in sub-Saharan Africa. It...
Source: Evidence-Based Medicine - September 24, 2015 Category: Internal Medicine Authors: Rosenthal, P. J. Tags: Clinical trials (epidemiology), Immunology (including allergy), Meningitis, Travel medicine, Tropical medicine (infectious diseases), Vaccination / immunisation, Infection (neurology) Therapeutics/Prevention Source Type: research

Question 1: Does prophylactic paracetamol prevent fever after vaccination in infants?
Scenario A 2-month-old infant is brought into the emergency department with a 24 h history of fever. He was born at term and had an uneventful neonatal period with no risk factors for sepsis. Clinical examination was unremarkable apart from a temperature of 38.5°C. Upon further questioning, his mother revealed that the infant had received his routine vaccinations the previous day. She had been advised to give prophylactic paracetamol at the time of vaccination but had refrained from doing so because, 2 years previously, the same practice nurse had told her to give paracetamol to her older child only if he dev...
Source: Archives of Disease in Childhood - November 19, 2015 Category: Pediatrics Authors: Braccio, S., Saliba, V., Ramsay, M., Ladhani, S. N. Tags: ADC Archimedes, Liver disease, Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Hepatitis and other GI infections, Meningitis, TB and other respiratory infections, Tropical medicine (infect Source Type: research

Encephalitis in Australian children: contemporary trends in hospitalisation
Conclusion Hospitalisation of childhood encephalitis has slightly decreased in Australia. High rates of childhood immunisation have been associated with a reduction of varicella-associated encephalitis in Australian children. ADEM, an immune-mediated encephalitis, is the most common recognised cause of encephalitis in children. Young children (<1 year) have the highest admission rates. The high proportion of ‘unspecified’ encephalitis deaths and hospitalisations is an ongoing challenge.
Source: Archives of Disease in Childhood - December 14, 2015 Category: Pediatrics Authors: Britton, P. N., Khoury, L., Booy, R., Wood, N., Jones, C. A. Tags: Health policy, Immunology (including allergy), Meningitis, Vaccination / immunisation, Infection (neurology), Health economics, Health service research Original article Source Type: research

No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine
A randomized controlled trial in Fiji examined the immunogenicity and effect on nasopharyngeal carriage after 0, 1, 2, or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7; Prevnar) in infancy followed by 23-valent pneumococcal polysaccharide vaccine (23vPPV; Pneumovax) at 12 months of age. At 18 months of age, children given 23vPPV exhibited immune hyporesponsiveness to a micro-23vPPV (20%) challenge dose in terms of serotype-specific IgG and opsonophagocytosis, while 23vPPV had no effect on vaccine-type carriage.
Source: Journal of Allergy and Clinical Immunology - January 26, 2016 Category: Allergy & Immunology Authors: Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J Source Type: research

New Vaccines in 2016 Pediatric Immunization Schedule New Vaccines in 2016 Pediatric Immunization Schedule
Recommendations for the recently licensed meningococcal B and 9-valent human papillomavirus vaccine are now in the official 2016 childhood immunization schedule Medscape Medical News
Source: Medscape Allergy Headlines - February 1, 2016 Category: Allergy & Immunology Tags: Pediatrics News Alert Source Type: news

2016 Adult Immunization Schedule Includes New Vaccines2016 Adult Immunization Schedule Includes New Vaccines
New vaccines against meningococcal serogroup B and human papillomavirus and a revision to the pneumococcal vaccine recommendation are among the 2016 changes. Medscape Medical News
Source: Medscape Allergy Headlines - February 1, 2016 Category: Allergy & Immunology Tags: Internal Medicine News Alert Source Type: news

The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis
Conclusions Among patients starting tofacitinib, diminished responsiveness to PPSV-23, but not influenza, was observed, particularly in those taking concomitant methotrexate. Among existing tofacitinib users, temporary drug discontinuation had limited effect upon influenza or PPSV-23 vaccine responses. Trial registration numbers NCT01359150, NCT00413699.
Source: Annals of the Rheumatic Diseases - March 10, 2016 Category: Rheumatology Authors: Winthrop, K. L., Silverfield, J., Racewicz, A., Neal, J., Lee, E. B., Hrycaj, P., Gomez-Reino, J., Soma, K., Mebus, C., Wilkinson, B., Hodge, J., Fan, H., Wang, T., Bingham, C. O. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Evaluation of the immunogenicity of the 13-valent conjugated pneumococcal vaccine in rheumatoid arthritis patients treated with etanercept
Conclusions In RA patients treated with ETA, vaccination with PCV13 is effective and safe, resulting in pAR one and two months after vaccination. Higher age at vaccination was identified as predictors of impaired pAR. The efficacy of vaccination may be more pronounced in younger RA patients. The vaccine is safe in RA patients on ETA.
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

The First World War years of Sydney Domville Rowland: an early case of possible laboratory-acquired meningococcal disease
Sydney Domville Rowland was a bacteriologist and staff member at the Lister Institute of Preventive Medicine when the First World War broke out in 1914. Following a request to the Director of the Lister Institute to staff and equip a mobile field laboratory as quickly as possible, Rowland was appointed to take charge of No. 1 Mobile Laboratory and took up a temporary commission at the rank of Lieutenant in the Royal Army Medical Corps. On 9 October 1914, Rowland set out for the European mainland and was subsequently attached to General Headquarters in Saint-Omer, France (October 1914-June 1915), No. 10 Casualty Clearing St...
Source: Journal of the Royal Army Medical Corps - July 28, 2016 Category: Journals (General) Authors: Wever, P. C., Hodges, A. J. Tags: Infectious diseases, Immunology (including allergy), Drugs: CNS (not psychiatric), Infection (neurology), Trauma, Injury, Health promotion Footnotes and endpieces Source Type: research

Infections Nearly Halved After Meningococcal Vaccine Intro in UK Infections Nearly Halved After Meningococcal Vaccine Intro in UK
Infant immunization with the Bexsero vaccine led to a 42% decrease in the number of cases of meningococcal B meningitis and septicemia in the first year.Medscape Medical News
Source: Medscape Allergy Headlines - September 12, 2016 Category: Allergy & Immunology Tags: Pediatrics News Source Type: news

Invasive meningococcal disease in children in Ireland, 2001-2011
Conclusions Despite the meningococcal C vaccination campaign, invasive meningococcal disease continues to cause serious morbidity and claim lives. Group B infections remain dominant. As children who die often present with fulminant disease, preventive strategies including use of meningococcal B vaccine are needed to avert death and sequelae.
Source: Archives of Disease in Childhood - November 17, 2016 Category: Pediatrics Authors: O Maoldomhnaigh, C., Drew, R. J., Gavin, P., Cafferkey, M., Butler, K. M. Tags: Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation Original article Source Type: research

The World Is Not Ready for the Next Pandemic
Across China, the virus that could spark the next pandemic is already circulating. It’s a bird flu called H7N9, and true to its name, it mostly infects poultry. Lately, however, it’s started jumping from chickens to humans more readily–bad news, because the virus is a killer. During a recent spike, 88% of people infected got pneumonia, three-quarters ended up in intensive care with severe respiratory problems, and 41% died. What H7N9 can’t do–yet–is spread easily from person to person, but experts know that could change. The longer the virus spends in humans, the better the chance that i...
Source: TIME.com: Top Science and Health Stories - May 4, 2017 Category: Consumer Health News Authors: Bryan Walsh Tags: Uncategorized CDC Disease ebola Gates Foundation MERS outbreak pandemic Zika Source Type: news

UK parents attitudes towards meningococcal group B (MenB) vaccination: a qualitative analysis
Conclusions The successful implementation of the MenB vaccination programme depends on its acceptance by parents. In view of parents’ recognition of the severity of meningitis and septicaemia, and successful introduction of other vaccines to prevent bacterial meningitis and septicaemia, the MenB vaccination programme is likely to be successful. However, the need for additional injections, the likelihood of post-immunisation fever and its management are issues about which parents will need information and reassurance from healthcare professionals. Public Health England has developed written information for parents, in...
Source: BMJ Open - May 4, 2017 Category: Journals (General) Authors: Jackson, C., Yarwood, J., Saliba, V., Bedford, H. Tags: Open access, Immunology (including allergy) Research Source Type: research