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GIST (ILEAL) Revealed by Peculiar Paraneoplastic-myositis and Hypo-Thyroidism
CONCLUSION: Upto 10% dermato-myositis 5% poly-myositis can be paraneoplastic manifestation of underlying solid organ malignancy. overexpression of thyroid-hormone-inactivating type 3 iodothyronine deiodinase (D3) enzyme from GIST tumours often leads to hypothyroidism. References 1.Maynard MA, Marino-Enriquez A, Fletcher JA, et al. Thyroid hormone inactivation in gastrointestinal stromal tumors. N Engl J Med 2014;370:1327-1334. 2.Samimi M, Nseir A, Kerdraon R, et al. Tumeur stromale duodenale revelee par une dermatomyosite paranéoplasiqueStromal duodenal tumor revealed by paraneoplastic dermatomyositis. Gastroenterol Clin ...
Source: Journal of the Association of Physicians of India - April 28, 2023 Category: General Medicine Authors: Chirantan Mandal Pradeep Kumar Dutta Source Type: research

Compound heterozygous mutations of the TNXB gene cause primary myopathy
This study identifies a TNX-deficient patient presenting with a primary muscle disorder, thus expanding the phenotypic spectrum of TNX-related abnormalities. Biopsy findings provide evidence that TNX deficiency leads to muscle softness and to mislocalization of myotendinous junctions.
Source: Neuromuscular Disorders - June 13, 2013 Category: Neurology Authors: Isabelle Pénisson-Besnier, Valérie Allamand, Philippe Beurrier, Ludovic Martin, Joost Schalkwijk, Ivonne van Vlijmen-Willems, Corine Gartioux, Fransiska Malfait, Delfien Syx, Laurent Macchi, Pascale Marcorelles, Brigitte Arbeille, Anne Croué, Anne De P Tags: Research papers Source Type: research

Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma.
Abstract Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian cancer, lung cancer, and colorectal cancer. However, a chronic hepatitis B virus (HBV) infection associated with dermatomyositis and hepatocellular carcinoma (HCC) has been very rarely reported. Here, we report a rare case of dermatomyositis coinciding with HBV-associated HCC. A 55-year-old male was confirmed to...
Source: The Korean Journal of Internal Medicine - March 1, 2014 Category: Internal Medicine Authors: Yang SY, Cha BK, Kim G, Lee HW, Kim JG, Chang SK, Kim HJ Tags: Korean J Intern Med Source Type: research

Small nerve fiber pathology in critical illness documented by serial skin biopsies
Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness. © 2014 Wiley Periodicals, Inc.
Source: Muscle and Nerve - October 12, 2014 Category: Internal Medicine Authors: Miroslav Skorna, Roman Kopacik, Eva Vlckova, Blanka Adamova, Milena Kostalova, Josef Bednarik Tags: Research Article Source Type: research

C4d Staining as Immunohistochemical Marker in Inflammatory Myopathies
The diagnosis of an inflammatory myopathy is often established based on basic histologic studies. Additional immunohistochemical studies are sometimes required to support the diagnosis and the classification of inflammatory myopathies. Staining for major histocompatibility complex 1 (MHC1) often shows increased sarcolemmal labeling in inflammatory myopathies. Endomysial capillary staining C5b-9 (membrane attack complex) is a feature that is reported as frequently associated with dermatomyositis. Immunohistochemical staining for C4d is widely used for various applications including the assessment of antibody-mediated reject...
Source: Applied Immunohistochemistry and Molecular Morphology - October 1, 2014 Category: Chemistry Tags: Research Articles Source Type: research

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