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Total 1260 results found since Jan 2013.

Genetic analysis of asthma exacerbations.
CONCLUSION: We were unable to confirm previously reported associations of genetic markers with asthma exacerbations. Although, in general, the patients studied had less severe asthma than patients in earlier reports, these results suggest involvement of similar pathways. TRIAL REGISTRATION: clinicaltrials.gov Identifiers: NTC00452699, NCT00452348, NTC00102765, NCT00843193. PMID: 23706709 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 29, 2013 Category: Allergy & Immunology Authors: Anderson WH, Koshy BT, Huang L, Mosteller M, Stinnett SW, Condreay LD, Ortega H Tags: Ann Allergy Asthma Immunol Source Type: research

Immunohistochemical dissimilarity between allergic fungal and nonfungal chronic rhinosinusitis.
CONCLUSION: Although CT scans and histological examination can assist the diagnosis of rhinosinusitis, tissue immunophenotyping can be used in defining different types of fungal and nonfungal CRS cases. PMID: 23710950 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - May 1, 2013 Category: ENT & OMF Authors: Ragab A, Samaka RM Tags: Am J Rhinol Allergy Source Type: research

Chapter 7: Allergic fungal rhinosinusitis.
Abstract Allergic fungal rhinosinusitis (AFRS) is a type of chronic rhinosinusitis in which patients classically exhibit nasal polyps, type I IgE-mediated hypersensitivity, characteristic findings on computed tomography scans, eosinophilic mucin, and positive fungal stain. New research has sought to further understand the pathophysiology of AFRS. However, this has also led to debate about the classification and predominance of this interesting disease process. Historically, patients with AFRS are immunocompetent. The disease is most prevalent in the southeast and south central United States and typically presents ...
Source: American Journal of Rhinology and Allergy - May 1, 2013 Category: ENT & OMF Authors: Laury AM, Wise SK Tags: Am J Rhinol Allergy Source Type: research

Bacterial biofilm formation after nasal packing in nasal mucosa-wounded mice.
CONCLUSION: Our results indicate that a nasal wound, nasal packing, and the existence of pathogenic bacteria are all essential elements for biofilm formation in healthy mice. This result indicated that biofilm formation may be avoided by shortening the duration of nasal packing and reducing the nasal wound. PMID: 23883799 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2013 Category: ENT & OMF Authors: Wang Y, Chen S, Chen J, Zhang W, Gong G, Zhou T, Kong W Tags: Am J Rhinol Allergy Source Type: research

Alternative ways of expressing forced expiratory volume in the first second and long-term mortality in elderly patients with asthma.
CONCLUSION: Although extensively used, FEV1 expressed as percentage of predicted does not seem to be the best predictor of mortality in elderly patients with asthma. Although no spirometric index can predict 5-year mortality in this population, FEV1 as a multiple of the sex-specific first percentile should be considered when longer-term prognostic stratification is needed. PMID: 24125145 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - October 18, 2013 Category: Allergy & Immunology Authors: Pedone C, Scarlata S, Zito A, Forastiere F, Scichilone N, Battaglia S, Bellia V, Antonelli-Incalzi R Tags: Ann Allergy Asthma Immunol Source Type: research

Virus-Specific Peptide Dependent NK Cell Cytotoxicity.
Abstract NK cells do not express recombination-dependent antigen-specific receptors and are traditionally defined as cells of the innate immune response. The activation of NK cells was believed to be controlled by the net balance of signals from a multitude of activating and inhibitory receptors irrespectively of antigen specificity. However, murine antigen-specific memory NK cells in liver have been described to mediate hapten or viral specific recall response and are capable of infiltrating to the site of infection. The mechanisms by which NK cells recognize target cells in an antigen-specific manner are largely...
Source: Inflammation and Allergy Drug Targets - February 10, 2014 Category: Allergy & Immunology Authors: Tong L, Assenmacher M, Zanker K, Jahn P Tags: Inflamm Allergy Drug Targets Source Type: research

A simple animal model of Staphylococcus aureus biofilm in sinusitis.
CONCLUSION: This biofilm model of sinusitis avoids excessive damage to the nasal cavity and sinuses of the rabbits. It may be a desirable animal model for studying the pathogenesis and eradication strategies of bacterial biofilms in sinusitis. PMID: 24717948 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2014 Category: ENT & OMF Authors: Jia M, Chen Z, Du X, Guo Y, Sun T, Zhao X Tags: Am J Rhinol Allergy Source Type: research

Can computed tomography score predict outcome of adenoidectomy for chronic rhinosinusitis in children.
CONCLUSION: Making the diagnosis of CRS in children seems to be critical in determining whether, initially, an adenoidectomy alone is an appropriate treatment, specifically for those who have asthma. PMID: 24717893 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2014 Category: ENT & OMF Authors: Ramadan HH, Makary CA Tags: Am J Rhinol Allergy Source Type: research

Regional and socioeconomic disparities in emergency department use of radiographic imaging for acute pediatric sinusitis.
CONCLUSION: The use of ED imaging in APS is appropriately associated with factors known to be associated with APS complications. However, additional disparities with respect to regional and socioeconomic factors exist. Interventions to eliminate these health care disparities in use of imaging resources may lead to quality improvement in care and outcomes for APS. PMID: 24717874 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2014 Category: ENT & OMF Authors: Sedaghat AR, Cunningham MJ, Ishman SL Tags: Am J Rhinol Allergy Source Type: research

Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients.
CONCLUSION: This study indicates that phage cocktail CT-SA can effectively eliminate S. aureus, in planktonic and biofilm forms, from the great majority of CIs from this hospital setting. In addition, its potential effect in preventing the emergence of BIMs was also established. Thus, CT-SA has the potential to treat S. aureus infection and biofilm in CRS patients. PMID: 24717868 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2014 Category: ENT & OMF Authors: Drilling A, Morales S, Jardeleza C, Vreugde S, Speck P, Wormald PJ Tags: Am J Rhinol Allergy Source Type: research

Allergy immunotherapy: what is the evidence for cost saving?
Purpose of reviewGiven the widespread prevalence of allergic disease, its substantially associated clinical and economic burden, the unique disease-modifying benefits of allergy immunotherapy (AIT), and increased availability of sublingual immunotherapy (SLIT), a critical update of the evidence for AIT-related cost savings [for both subcutaneous immunotherapy (SCIT) and SLIT] is particularly relevant and timely. The present article reviews the evidence for SCIT-related and SLIT-related cost savings derived from a systematic review of the published literature. Recent findingsExamined were 24 publications pertaining to the h...
Source: Current Opinion in Allergy and Clinical Immunology - May 23, 2013 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by David A. Khan and Enrico Compalati Source Type: research

International study of the incidence of particular types of septal deformities in chronic rhinosinusitis patients: The outcomes from five countries.
CONCLUSION: Type 3 deformity has been found frequently in CRS patients in all five of the countries. Russian subjects exhibited a high frequency of type 4 deformity. Because this type consists of types 2 and 3, the later, again, has been proven to be prevalent in CRS patients also in this group of patients. PMID: 25198027 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - September 1, 2014 Category: ENT & OMF Authors: Cingi C, Bayar Muluk N, Acar M, Skitarelić N, Markešić J, Vugrinec O, Passali D, Bellussi L, Passali GC, Passali FM, Lopatin A, Kirdeeva A, Ivanchenko O, Sarafoleanu C, Negrila AM, Manea C Tags: Am J Rhinol Allergy Source Type: research

Respiratory epithelial adenomatoid hamartoma of the nose: An updated review.
CONCLUSION: Looking for REAH on CT scans and during endoscopic examination can lead to its diagnosis and help avoid aggressive surgical procedures and their complications. Endoscopic resection is the treatment of choice. The removal of REAH constitutes a specific surgery on the olfactory clefts, which can improve nasal obstruction as well as sense of smell. Whether REAH can be defined as a hamartoma, an inflammatory reactive process, or a neoplastic lesion remains to be determined. PMID: 25198016 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - September 1, 2014 Category: ENT & OMF Authors: Nguyen DT, Gauchotte G, Arous F, Vignaud JM, Jankowski R Tags: Am J Rhinol Allergy Source Type: research

A Quantitative Study of Airway Changes on Micro-CT in a Mouse Asthma Model: Comparison With Histopathological Findings.
CONCLUSIONS: The results of this study suggest that asthma may induce thickening of bronchial wall and narrowing of the lumen area on micro-CT images and that these results may significantly correlate with pathological findings. PMID: 24404397 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Objective radiographic density measurements of sinus opacities are not strong predictors of noninvasive fungal disease.
CONCLUSION: Higher average HU more accurately predicts allergic fungal mucin whereas heterogeneity/high-density components more accurately predict fungal balls. No objective radiographic density measure, in isolation, is both sensitive and specific in predicting noninvasive fungal sinusitis. PMID: 25514484 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2014 Category: ENT & OMF Authors: Killeen DE, Sedaghat AR, Cunnane ME, Gray ST Tags: Am J Rhinol Allergy Source Type: research