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Total 1303 results found since Jan 2013.
Confirmation of Hyperimmunoglobulin E Syndrome in Two Patients with an Ocular Problem: Detection of Two New DOCK8 Mutations
This study aimed to confirm the diagnosis of two cases of autosomal recessive hyper-immunoglobulin E (IgE) syndrome (AR-HIES), presenting with irreversible eye involvement. Two unrelated patients with suspected AR-HIES were referred to the Immunology, Asthma and Allergy Research Institute (IAARI), Tehran, Iran. Immunological screening tests were performed for AR-HIES, which showed elevated serum IgE levels, eosinophilia, and low T-lymphocyte responses. NGS was performed, and the results were confirmed by Sanger sequencing. Sequence analysis showed a mutation in intron 17 of the dedicator of cytokinesis 8 (DOCK8) gene in th...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Shiva Saghafi Fariborz Zandieh Mohammad Reza Fazlollahi Cristina Glocker Natalie Frede Mary Buchta Linlin Yang Amir Hossein Mahmoudi Massoud Houshmand Zahra Pourpak Bodo Grimbacher Mostafa Moin Source Type: research
Advances in basic and clinical immunology in 2012
Basic and clinical immunology articles published in the Journal in 2012 were mostly related to the expanding area of primary immunodeficiencies (PIDs). Novel forms of PID were identified by using whole-exome sequencing or after careful examination of flow cytometric data, as in the reports of lymphocyte-specific protein tyrosine kinase, CD27, and CD21 deficiencies. Absent IgG and IgA memory B cells were described in patients with hyper-IgE syndrome, which is consistent with defective antibody response and suggests a potential benefit of immunoglobulin replacement. Impaired production of antibodies to polysaccharide antigen...
Source: Journal of Allergy and Clinical Immunology - January 31, 2013 Category: Allergy & Immunology Authors: Javier Chinen, Luigi D. Notarangelo, William T. Shearer Tags: Advances in allergy, asthma, and immunology series 2013 Source Type: research
IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses
Conclusion: Our data show the characterization of IL-10+ BR1 cells and in vivo evidence for 2 essential features of allergen tolerance: the suppressive B cells and IgG4-expressing B cells that are confined to IL-10+ BR1 cells in human subjects.
Source: Journal of Allergy and Clinical Immunology - February 28, 2013 Category: Allergy & Immunology Authors: Willem van de Veen, Barbara Stanic, Görkem Yaman, Marcin Wawrzyniak, Stefan Söllner, Deniz G. Akdis, Beate Rückert, Cezmi A. Akdis, Mübeccel Akdis Tags: Mechanisms of allergy and clinical immunology Source Type: research
Drug allergy in haematopoietic stem cell transplantation.
PMID: 23537592 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - March 25, 2013 Category: Allergy & Immunology Authors: Gordon J, Damstetter E, Nardone B, Mehta J, West DP, Cotliar J Tags: Allergol Immunopathol (Madr) Source Type: research
Natural killer cells in patients with allergic diseases
Natural killer (NK) cells not only exert cytotoxic activity against tumor cells or infected cells but also act to regulate the function of other immune cells through secretion of cytokines and chemokines or cell contact–dependent mechanisms. NK cells are able to polarize in vitro into 2 functional distinct subsets, NK1 or NK2 cells, which are analogous to the T-cell subsets TH1 or TH2. In addition, a regulatory NK cell subset has been described that secretes IL-10, shows antigen-specific T-cell suppression, and suppresses IgE production. Although it has been demonstrated that NK cells play important roles in autoimmunit...
Source: Journal of Allergy and Clinical Immunology - August 29, 2013 Category: Allergy & Immunology Authors: Günnur Deniz, Willem van de Veen, Mübeccel Akdis Tags: Mechanisms of allergic diseases Source Type: research
Correction
With regard to the November 2011 article entitled “Hematopoietic stem cell transplantation for CD3δ deficiency” (J Allergy Clin Immunol 2011;128:1050-7), in Table II the IgE units should read U/mL and the IgE for patient 3 should read 2.79. The eosinophil number for patient 3 should read 150. The authors regret the error.
Source: Journal of Allergy and Clinical Immunology - October 30, 2013 Category: Allergy & Immunology Tags: Corrections Source Type: research
Did Bone Marrow Transplant Cure Peanut Allergy?
Unusual case report details how 10-year-old boy was treated for leukemia and lost sensitivity to peanuts
Source: The Doctors Lounge - Oncology - November 8, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Allergy, News, Source Type: news
Peanut Allergy, Bone Marrow Link Offers Clues
BALTIMORE (MedPage Today) -- An 8-year-old boy was cured of his peanut allergy following a bone marrow transplant for acute lymphocytic Leukemia (ALL), a researcher reported here.
Source: MedPage Today State Required CME - November 13, 2013 Category: Consumer Health News Source Type: news
Advances in basic and clinical immunology in 2013
A significant number of contributions to our understanding of primary immunodeficiencies (PIDs) in pathogenesis, diagnosis, and treatment were published in the Journal in 2013. For example, deficiency of mast cell degranulation caused by signal transducer and activator of transcription 3 deficiency was demonstrated to contribute to the difference in the frequency of severe allergic reactions in patients with autosomal dominant hyper-IgE syndrome compared with that seen in atopic subjects with similar high IgE serum levels. High levels of nonglycosylated IgA were found in patients with Wiskott-Aldrich syndrome, and these ab...
Source: Journal of Allergy and Clinical Immunology - March 3, 2014 Category: Allergy & Immunology Authors: Javier Chinen, Luigi D. Notarangelo, William T. Shearer Tags: Advances in allergy, asthma, and immunology series 2014 Source Type: research
Peanut allergy transferred by BMT
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Source: Bone Marrow Transplantation - April 28, 2014 Category: Hematology Authors: W IpC CaleP VeysW Qasim Source Type: research
Acquired IgE-mediated food allergy after liver transplantation in children.
CONCLUSION: The risk of developing IgE-mediated food allergies is approximately three times higher within the first year after transplantation than in subsequent years.
PMID: 25201761 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - September 5, 2014 Category: Allergy & Immunology Authors: Catal F, Topal E, Selimoglu MA, Karabiber H, Baskıran A, Senbaba E, Varol I, Yılmaz S Tags: Allergol Immunopathol (Madr) Source Type: research
The Role of Atypical Infections and Macrolide Therapy in Patients with Asthma
This article will review the use of macrolides in the treatment of asthma.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 12, 2014 Category: Allergy & Immunology Source Type: research
Successful stem cell transplantation in Chediak-Higashi syndrome
Publication date: Available online 18 November 2014 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Ami Thakor , Bob Geng , Myron Liebhaber , Theodore Moore , Kevin Wang , Robert L. Roberts
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 18, 2014 Category: Allergy & Immunology Source Type: research
