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Specialty: Allergy & Immunology
Nutrition: Vitamins
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Total 847 results found since Jan 2013.
Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients
In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on γδ T cells. Interestingly, 1α,25(OH)2 D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV-infected patients and promoted IFN-β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T-cell exhaustion and is highly promising target for ameliorati...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Ke Li Eying Lu Qian Wang Ruirong Xu Wenhui Yuan Ruan Wu Ligong Lu Peng Li Source Type: research
SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice
This study aimed to investigate the effect of NA in lipopolysaccharide (LPS) mouse model of depression exploring its ability to regulate sirtuin1/poly (ADP-ribose) polymerase-1 (PARP-1)/nod-likereceptor protein 3 (NLRP3) signaling.MAIN METHODS: Mice were injected with LPS (500 µg/kg, i.p) every other day alone or concurrently with oral doses of either NA (40 mg/kg/day) or escitalopram (10 mg/kg/day) for 14 days.KEY FINDINGS: Administration of NA resulted in significant attenuation of animals' despair reflected by decreased immobility time in forced swimming test. Moreover, NA induced monoamines upsurge in addition to sirt...
Source: International Immunopharmacology - August 10, 2023 Category: Allergy & Immunology Authors: Nora O Abdel Rasheed Nesma A Shiha Sarah S Mohamed Weam W Ibrahim Source Type: research
Skin-derived TSLP stimulates skin migratory dendritic cells to promote the expansion of regulatory T cells
This article is protected by copyright. All rights reserved.PMID:37525585 | DOI:10.1002/eji.202350390
Source: European Journal of Immunology - August 1, 2023 Category: Allergy & Immunology Authors: Yukinori Tanaka Yuichi Yokoyama Taku Kambayashi Source Type: research
Effect of Vitamin D on the HMGB1/RAGE Pathway and Adipokines Levels in Obese Asthmatic Mice
In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). Accordingly, thirty mice were randomly divided into 5 equal groups of normal control, asthma, obese asthma, asthma+Vit D, and obese asthma+ Vit D. The levels of inflammatory factors and adipokines were measured by the ELISA assay; then the quantitative reverse transcription PCR (qRT-PCR) method was used to evaluate the expression of high mobility group box 1(HMGB1) and receptor for advanced glycation end products [RAGE] genes.T he results showed that OVA s...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Yijia Fan Junguo Chen Xiaofeng Zhu Source Type: research
Vitamin D and autophagy in knee osteoarthritis: A review
Int Immunopharmacol. 2023 Jul 28;123:110712. doi: 10.1016/j.intimp.2023.110712. Online ahead of print.ABSTRACTKnee osteoarthritis (KOA), the highly prevalent degenerative disease affecting the joint, perpetually devastates the health of the elderly. Of various mechanisms known to participate in KOA etiology, apoptosis of chondrocytes is widely regarded as the primary cause of cartilage degradation. It has been suggested that the induction of autophagy in chondrocytes could potentially prolong the progression of KOA by modulating intracellular metabolic processes, which may be helpful for ameliorating chondrocyte apoptosis ...
Source: International Immunopharmacology - July 31, 2023 Category: Allergy & Immunology Authors: Wacharapol Saengsiwaritt Phatchana Ngamtipakon Wanvisa Udomsinprasert Source Type: research
Effect of Vitamin D on the HMGB1/RAGE Pathway and Adipokines Levels in Obese Asthmatic Mice
In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). Accordingly, thirty mice were randomly divided into 5 equal groups of normal control, asthma, obese asthma, asthma+Vit D, and obese asthma+ Vit D. The levels of inflammatory factors and adipokines were measured by the ELISA assay; then the quantitative reverse transcription PCR (qRT-PCR) method was used to evaluate the expression of high mobility group box 1(HMGB1) and receptor for advanced glycation end products [RAGE] genes.T he results showed that OVA s...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Yijia Fan Junguo Chen Xiaofeng Zhu Source Type: research
Vitamin D and autophagy in knee osteoarthritis: A review
Int Immunopharmacol. 2023 Jul 28;123:110712. doi: 10.1016/j.intimp.2023.110712. Online ahead of print.ABSTRACTKnee osteoarthritis (KOA), the highly prevalent degenerative disease affecting the joint, perpetually devastates the health of the elderly. Of various mechanisms known to participate in KOA etiology, apoptosis of chondrocytes is widely regarded as the primary cause of cartilage degradation. It has been suggested that the induction of autophagy in chondrocytes could potentially prolong the progression of KOA by modulating intracellular metabolic processes, which may be helpful for ameliorating chondrocyte apoptosis ...
Source: International Immunopharmacology - July 31, 2023 Category: Allergy & Immunology Authors: Wacharapol Saengsiwaritt Phatchana Ngamtipakon Wanvisa Udomsinprasert Source Type: research
Effect of Vitamin D on the HMGB1/RAGE Pathway and Adipokines Levels in Obese Asthmatic Mice
In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). Accordingly, thirty mice were randomly divided into 5 equal groups of normal control, asthma, obese asthma, asthma+Vit D, and obese asthma+ Vit D. The levels of inflammatory factors and adipokines were measured by the ELISA assay; then the quantitative reverse transcription PCR (qRT-PCR) method was used to evaluate the expression of high mobility group box 1(HMGB1) and receptor for advanced glycation end products [RAGE] genes.T he results showed that OVA s...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Yijia Fan Junguo Chen Xiaofeng Zhu Source Type: research
