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Effectiveness and Safety of Home-based Oral Immunotherapy for Wheat Allergy: A Single-Center Analysis
We aimed to investigate the efficacy and safety of the home-based oral immunotherapy (OIT) in children with wheat allergy.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jihyun Kim, Jiwon Kim, Minyoung Jung, Su Kyung Kim, Sehum Jang, Sanghee Shin, Seeun Park, Minji Kim, Ji Young Lee, Kangmo Ahn Source Type: research

Recall urticaria in patient with celiac disease
Recall urticaria refers to an urticarial response localized to an area of prior antigen exposure and reactivated by various stimuli, typically allergy immunotherapy. Our case describes a patient, ultimately diagnosed with celiac disease, who experiences episodes of recall urticaria at site of previous allergy immunotherapy after ingestion of wheat.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Lee, K. Cook, J. Kelso, A. White Tags: M129 Source Type: research

The clinical significance of allergen-specific IgG4 in allergic diseases
IgG4 is a subclass of IgG antibody with a unique molecular feature of (Fragment antigen- binding) Fab-arm exchange, allowing bispecific antigen binding in a mono-valent manner. With low binding affinity to C1q and Fcγreceptors, IgG4 is incapable of forming immune complexes and activating the complement pathway, exhibiting a non-inflammatory feature. IgG4 is produced similarly to IgE and is considered a modified reaction to IgE class-switching response under certain conditions. It could also counteract IgE-activated inflammation. However, the clinical significance of IgG4 in allergic diseases is complex and controversial. ...
Source: Frontiers in Immunology - October 25, 2022 Category: Allergy & Immunology Source Type: research

The Efficacy of a New Protocol of Oral Immunotherapy to Wheat for Desensitization and Induction of Tolerance
This study aimed to design and implement a new wheat OIT protocol, evaluate its efficacy in tolerance induction, and assess specific immunoglobulin-E (IgE) and regulatory T cell changes. From 2015 to 2017, 26 patients with confirmed IgE-mediated hypersensitivity to wheat were treated via oral immunotherapy (OIT). Patients with prior anaphylactic episodes underwent OIT using the rush method. Specific IgE concentrations and the number of regulatory T cells (CD4+ CD25+ FOXP3+ T cells) were measured using Allergy Screen immunoblot assay and flow cytometry, respectively. This study was registered in the Iranian Registry of Clin...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Samin Sharafian Aliakbar Amirzargar Mohammad Gharagozlou Nima Parvaneh Mansoureh Shariat Marzieh Tavakol Masoud Movahedi Source Type: research

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