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Total 22265 results found since Jan 2013.
Predictors of response to a lapse in anti-VEGF treatment in patients with macular edema secondary to retinal vein occlusion
CONCLUSIONS: Patients' responses to treatment lapses for ME secondary to RVO can be predicted with reasonable accuracy using readily available clinical data, particularly age, BMI, time since diagnosis, and history of dyslipidemia. Providers should consider these factors when counselling patients and determining follow-up schedules.PMID:37716706 | DOI:10.1016/j.jcjo.2023.08.002
Source: Canadian Journal of Ophthalmology - September 16, 2023 Category: Opthalmology Authors: Christopher M Maatouk Jessica C Liu Peter Alsaloum Amogh I Iyer Peter M Kaiser Rishi P Singh Katherine E Talcott Source Type: research
Total recall: the role of PIDDosome components in neurodegeneration
Trends Mol Med. 2023 Sep 14:S1471-4914(23)00193-4. doi: 10.1016/j.molmed.2023.08.008. Online ahead of print.ABSTRACTThe PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell differentiation, tissue homeostasis, and organogenesis and regeneration, caspase-2, RAIDD and PIDD1 engagement in neuronal development was shown. Here, we focus on th...
Source: Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Pavel I Volik Gelina S Kopeina Boris Zhivotovsky Alexey V Zamaraev Source Type: research
Exudative vascular anomalous complex-like lesion of the peripapillary area
CONCLUSION: Exudative intraretinal aneurysmal lesions can occur in areas other than perifoveal area. OCT is an useful investigation for knowing their characteristics and the response to treatment. These aneurysmal lesions irrespective of their location can be called by the name eVAC-like or more aptly retinal capillary macro aneurysms (RCM).PMID:37715627 | DOI:10.1177/11206721231202895
Source: European Journal of Ophthalmology - September 16, 2023 Category: Opthalmology Authors: Shreyas Temkar Kaviyapriya Natarajan Amit Kumar Deb Pradeep Sagar Source Type: research
Predictors of response to a lapse in anti-VEGF treatment in patients with macular edema secondary to retinal vein occlusion
CONCLUSIONS: Patients' responses to treatment lapses for ME secondary to RVO can be predicted with reasonable accuracy using readily available clinical data, particularly age, BMI, time since diagnosis, and history of dyslipidemia. Providers should consider these factors when counselling patients and determining follow-up schedules.PMID:37716706 | DOI:10.1016/j.jcjo.2023.08.002
Source: Canadian Journal of Ophthalmology - September 16, 2023 Category: Opthalmology Authors: Christopher M Maatouk Jessica C Liu Peter Alsaloum Amogh I Iyer Peter M Kaiser Rishi P Singh Katherine E Talcott Source Type: research
Exudative vascular anomalous complex-like lesion of the peripapillary area
CONCLUSION: Exudative intraretinal aneurysmal lesions can occur in areas other than perifoveal area. OCT is an useful investigation for knowing their characteristics and the response to treatment. These aneurysmal lesions irrespective of their location can be called by the name eVAC-like or more aptly retinal capillary macro aneurysms (RCM).PMID:37715627 | DOI:10.1177/11206721231202895
Source: European Journal of Ophthalmology - September 16, 2023 Category: Opthalmology Authors: Shreyas Temkar Kaviyapriya Natarajan Amit Kumar Deb Pradeep Sagar Source Type: research
Predictors of response to a lapse in anti-VEGF treatment in patients with macular edema secondary to retinal vein occlusion
CONCLUSIONS: Patients' responses to treatment lapses for ME secondary to RVO can be predicted with reasonable accuracy using readily available clinical data, particularly age, BMI, time since diagnosis, and history of dyslipidemia. Providers should consider these factors when counselling patients and determining follow-up schedules.PMID:37716706 | DOI:10.1016/j.jcjo.2023.08.002
Source: Canadian Journal of Ophthalmology - September 16, 2023 Category: Opthalmology Authors: Christopher M Maatouk Jessica C Liu Peter Alsaloum Amogh I Iyer Peter M Kaiser Rishi P Singh Katherine E Talcott Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Environment International - September 16, 2023 Category: Environmental Health Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
Total recall: the role of PIDDosome components in neurodegeneration
Trends Mol Med. 2023 Sep 14:S1471-4914(23)00193-4. doi: 10.1016/j.molmed.2023.08.008. Online ahead of print.ABSTRACTThe PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell differentiation, tissue homeostasis, and organogenesis and regeneration, caspase-2, RAIDD and PIDD1 engagement in neuronal development was shown. Here, we focus on th...
Source: Trends in Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Pavel I Volik Gelina S Kopeina Boris Zhivotovsky Alexey V Zamaraev Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Alterations of fecal microbiome and metabolome in pemphigus patients
J Autoimmun. 2023 Sep 13:103108. doi: 10.1016/j.jaut.2023.103108. Online ahead of print.ABSTRACTThe role of gut microbiome and metabolic substances in the development of autoimmune diseases has gradually been revealed. However, the relevant gut features in pemphigus have not been well clarified. We collected stool samples from pemphigus patients and healthy controls (HCs). Metagenomic sequencing and liquid chromatography-mass spectrometry (LC/MS) metabolome sequencing were performed to analyze the compositional and metabolic alternations of the gut microbiome in pemphigus patients and HCs. We observed the reduced richness ...
Source: Journal of Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Ziyu Guo Nam Yiu Zhi Hu Wenyu Zhou Xuan Long Miao Yang Jieyue Liao Guiying Zhang Qianjin Lu Ming Zhao Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
