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Eosinophilic esophagitis during sublingual and oral allergen immunotherapy
Purpose of review The aim of this review is to discuss the current evidence regarding the development of eosinophilic esophagitis (EoE) in individuals undergoing oral and sublingual immunotherapy (SLIT) for both food and environmental allergens. Cumulative incidence of EoE in patients on allergen immunotherapy for peanut, milk, and egg is estimated. Recent findings De novo development of EoE in patients undergoing oral and SLIT has been demonstrated on the scale of case reports and prospective randomized trials. However, few individuals with EoE-like symptoms during immunotherapy undergo endoscopy, and the long-term o...
Source: Current Opinion in Allergy and Clinical Immunology - June 27, 2019 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Ignacio J. Ansotegui Source Type: research

Eosinophilic esophagitis: Pathophysiology, diagnosis, and management.
Abstract Eosinophilic esophagitis (EoE) is a multifactorial esophageal inflammation, with a genetic predisposition, which combines a deficient esophageal mucosal barrier, an abnormal immune reaction to environmental allergens mediated by Th2 interleukins, immediate esophageal lesions and dysmotility, with secondary remodeling and fibrosis. Symptoms include reflux, abdominal pain, and food impaction, with a variation according to age. Fibroscopy shows major and minor endoscopic and histologic criteria, with a mucosal count≥15 eosinophils/high power field (Eo/hpf). A new entity has been defined, where gastroesopha...
Source: Archives de Pediatrie - February 27, 2019 Category: Pediatrics Authors: Vinit C, Dieme A, Courbage S, Dehaine C, Dufeu CM, Jacquemot S, Lajus M, Montigny L, Payen E, Yang DD, Dupont C Tags: Arch Pediatr Source Type: research

Treatment of gastric eosinophilia by epicutaneous immunotherapy in piglets sensitized to peanuts
ConclusionsThis study describes a large animal model of gastric eosinophil in peanut‐sensitized piglets. Utilizing this model, we demonstrated the efficacy of EPIT in treating peanut‐induced EGIDs.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 28, 2017 Category: Allergy & Immunology Authors: L. Mondoulet, N. Kalach, V. Dhelft, T. Larcher, C. Delayre ‐Orthez, P H. Benhamou, J. Spergel, H A. Sampson, C. Dupont Tags: Original Article ‐Experimental Models of Allergic Disease Source Type: research

Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut
ConclusionsPropofol was safely administered for procedural sedation in a large series of adult EoE patients multisensitized to egg, soy, peanut, showing one‐third clinical allergy to these foods.
Source: Allergy - January 21, 2014 Category: Allergy & Immunology Authors: J. Molina‐Infante, A. Arias, D. Vara‐Brenes, R. Prados‐Manzano, J. Gonzalez‐Cervera, M. Alvarado‐Arenas, A. J. Lucendo Tags: Original Article Source Type: research