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Specialty: Microbiology
Nutrition: Organic

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Total 1778 results found since Jan 2013.

Evaluation of Antimicrobial Activity of Four Organic Acids Used in Chicks Feed to Control Salmonella typhimurium: Suggestion of Amendment in the Search Standard.
Authors: El Baaboua A, El Maadoudi M, Bouyahya A, Belmehdi O, Kounnoun A, Zahli R, Abrini J Abstract Today, the general public has become increasingly aware of salmonellosis problems. Organic acids are known by their antimicrobial potential and commonly used for improving the quality of poultry feed. In this context, the present work evaluated the inhibitory effect of four organic acids, namely, acetic acid, citric acid, lactic acid, and tartaric acid, at different levels of contamination by Salmonella typhimurium. The neutralization of these organic acids in vitro and in the presence of one-day-old chick's organs ...
Source: International Journal of Microbiology - October 28, 2018 Category: Microbiology Tags: Int J Microbiol Source Type: research

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player
The 1940s and 1950s witnessed a diverse search for not just natural product antibiotics but also for synthetic and semisynthetic compounds. This review revisits this epoch, using the research by a Danish pharmaceutical company, LEO Pharma, as an example. LEO adopted a strategy searching for synthetic antibiotics toward specific bacterial pathogens, in particular Mycobacterium tuberculosis, leading to the discovery of a new derivative of a known drug. Work on penicillin during and after WWII lead to the development of associated salts/esters and a search for new natural product antibiotics. This led initially to no new, mar...
Source: Frontiers in Microbiology - June 11, 2020 Category: Microbiology Source Type: research

Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search.
Abstract Optimization of export mechanisms for valuable extracellular products is important for the development of efficient microbial production processes. Identification of the relevant export mechanism is the prerequisite step for product export optimization. In this work, we identified transporters involved in malate export in an engineered L-malate-producing Escherichia coli strain using cheminformatics-guided genetics tests. Among all short-chain di- or tricarboxylates with known transporters in E. coli, citrate, tartrate, and succinate are most chemically similar to malate as estimated by their molecular si...
Source: Applied Microbiology and Biotechnology - October 21, 2019 Category: Microbiology Authors: Kurgan G, Kurgan L, Schneider A, Onyeabor M, Rodriguez-Sanchez Y, Taylor E, Martinez R, Carbonell P, Shi X, Gu H, Wang X Tags: Appl Microbiol Biotechnol Source Type: research

The enigma of Pacini's < em > Vibrio cholerae < /em > discovery
J Med Microbiol. 2021 Nov;70(11). doi: 10.1099/jmm.0.001450.ABSTRACTDuring the 1854 cholera outbreak in Florence, Italy, Filippo Pacini documented that the cause of the infection was a bacterium. This conclusion was also independently reached by John Snow during the 1854 cholera outbreak in London. By using an epidemiological method, Snow found that the infection spread through a polluted water network. Snow identified a water pump as the source of the disease. After removing the infected handle of this pump, the cases of cholera rapidly began to decrease. A microscopic examination of the water showed organic impurities bu...
Source: Journal of Medical Microbiology - November 5, 2021 Category: Microbiology Authors: Gian Piero Carboni Source Type: research

Volatile compounds from < em > in vitro < /em > metabolism of seven < em > Listeria monocytogenes < /em > isolates belonging to different clonal complexes
J Med Microbiol. 2022 Jun;71(6). doi: 10.1099/jmm.0.001553.ABSTRACTMicroorganisms produce a wide variety of volatile organic compounds (VOCs) as products of their metabolism and some of them can be specific VOCs linked to the microorganism's identity, which have proved to be helpful for the diagnosis of infection via odour fingerprinting. The aim of this study was to determine the VOCs produced and consumed to characterize the volatile metabolism of seven isolates of different clonal complexes (CCs) of Listeria monocytogenes. For this purpose, dichloromethane extracts from the thioglycolate broth medium were analysed by ga...
Source: Journal of Medical Microbiology - June 20, 2022 Category: Microbiology Authors: Esperanza Lepe-Balsalobre Ricardo Rubio-S ánchez Cristina Ubeda Jos é Antonio Lepe Source Type: research

Prediction of genome-wide imipenem resistance features in < em > Klebsiella pneumoniae < /em > using machine learning
Conclusion. Machine-learning methods could effectively predict the imipenem resistance feature in K. pneumoniae, and provide resistance sequence profiles for predicting resistance phenotype and exploring potential resistance mechanisms. It provides an important insight into the potential therapeutic strategies of K. pneumoniae resistance to imipenem, and speed up the application of machine learning in routine diagnosis.PMID:36753438 | DOI:10.1099/jmm.0.001657
Source: Journal of Medical Microbiology - February 8, 2023 Category: Microbiology Authors: Shanshan Li Jun Wu Nan Ma Wenjia Liu Mengjie Shao Nanjiao Ying Lei Zhu Source Type: research