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Specialty: Cytology
Nutrition: Iron
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Total 18 results found since Jan 2013.
Regulation of Hippo/YAP signaling pathway ameliorates cochlear hair cell injury by regulating ferroptosis
In conclusion, YAP1 ameliorated cochlear hair cell injury by upregulating FTL and TFRC to suppress ferroptosis.PMID:36889225 | DOI:10.1016/j.tice.2023.102051
Source: Tissue and Cell - March 8, 2023 Category: Cytology Authors: Xiaorong Niu Peng Han Junsong Liu Zichen Chen Xiaoyan Ma Ting Zhang Baiya Li Xudong Ma Source Type: research
Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin
We examined the role of DMT1 inhibition or salinomycin in promoting ferroptosis by lysosomal iron targeting in HNC cells. RNA interference was performed by transfection of siRNA targeting DMT1 or scrambled control siRNA in HNC cell lines. Cell death and viability, lipid peroxidation, iron contents, and molecular expression were compared between the DMT1 silencing or salinomycin group and the control. DMT1 silencing markedly accelerated cell death induced by the ferroptosis inducers. DMT1 silencing marked increases in the labile iron pool, intracellular ferrous and total iron contents, and lipid peroxidation. DMT1 silencing...
Source: Human Cell - March 8, 2023 Category: Cytology Source Type: research
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
In this study, we investigated the neuroprotective effects and underlying mechanism for WFA in the regulation of ICH-induced oxidative stress and ferroptosis. We established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced ICH. WFA was injected intracerebroventricularly at 0.1, 1 or 5 µg/kg once daily for 7 days, starting immediately after ICH operation. WFA markedly reduced brain tissue injury and iron deposition and improved neurological function in a dose-dependent manner 7 days after cerebral hemorrhage. Through in vitro experiments,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Zi-Xian Zhou Qi Cui Ying-Mei Zhang Jia-Xin Yang Wen-Jing Xiang Ning Tian Yan-Lin Jiang Mei-Ling Chen Bin Yang Qing-Hua Li Ru-Jia Liao Source Type: research
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia-reperfusion injury
CONCLUSIONS: USP7 inhibition attenuated I/R-induced renal injury by inhibiting ferroptosis through decreasing ubiquitination of TBK1 and promoting DNMT1-mediated methylation of FMR1.PMID:36264362 | DOI:10.1007/s00011-022-01648-1
Source: Cell Research - October 20, 2022 Category: Cytology Authors: Boqing Dong Chenguang Ding Heli Xiang Jin Zheng Xiao Li Wujun Xue Yang Li Source Type: research
Endothelin-1 Depletion of Cartilage Oligomeric Matrix Protein Modulates Pulmonary Artery Superoxide and Iron Metabolism-associated Mitochondrial Heme Biosynthesis
This study examines if heme biosynthesis associated iron metabolism is regulated in pulmonary arteries by endothelin-1 (ET1) potentially through modulating Cartilage Oligomeric Matrix Protein (COMP) availability. Our studies in organoid cultured endothelium-rubbed bovine pulmonary arteries (BPA) observed COMP depletion by siRNA or hypoxia increases NOX2 and superoxide, and depletes mitochondrial SOD2. ET1 also increases superoxide in a manner that potentially impairs mitochondrial heme biosynthesis. In this study, organoid culture of BPA with ET1 (10nM) increases superoxide in the mitochondrial matrix and extra mitochondri...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 9, 2022 Category: Cytology Authors: Hang Yu Norah Alruwaili Melissa R Kelly Bin Zhang Aijing Liu Yingqi Wang Dong Sun Michael S Wolin Source Type: research
Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway
In this study, we attempted to investigate a novel mechanism by which WG mitigates liver fibrosis by inducing ferroptosis in hepatic stellate cells (HSCs). A CCl4 -induced mouse liver fibrosis model and a rat HSC line were employed for in vivo and in vitro experiments, both treated with WG. Firstly, the levels of the fibrotic markers α-smooth muscle actin (α-SMA) and α1(I)collagen (COL1α1) were effectively decreased by WG in CCl4 -induced mice and HSC-T6 cells. Additionally, mitochondrial condensation and mitochondrial ridge breakage were observed in WG-treated HSC-T6 cells. Furthermore, ferroptotic events including de...
Source: Cell Research - July 11, 2022 Category: Cytology Authors: Guofang Liu Can Wei Siyu Yuan Zhe Zhang Jiahao Li Lijun Zhang Guokai Wang Ling Fang Source Type: research
GAK and PRKCD kinases regulate basal mitophagy
Autophagy. 2022 Jan 9:1-3. doi: 10.1080/15548627.2021.2015154. Online ahead of print.ABSTRACTThe removal of mitochondria in a programmed or stress-induced manner is essential for maintaining cellular homeostasis. To date, much research has focused upon stress-induced mitophagy that is largely regulated by the E3 ligase PRKN, with limited insight into the mechanisms regulating basal "housekeeping" mitophagy levels in different model organisms. Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act a...
Source: Autophagy - January 10, 2022 Category: Cytology Authors: Michael J Munson Benan J Mathai Matthew Yoke Wui Ng Laura Trachsel-Moncho Laura R de la Ballina Anne Simonsen Source Type: research
Ferritin: A Multifunctional Nanoplatform for Biological Detection, Imaging Diagnosis, and Drug Delivery
We reported that human HFn could selectively deliver a large amount of cargo into tumors in vivo via transferrin receptor 1 (TfR1)-mediated tumor-cell-specific targeting followed by rapid internalization. By the use of the intrinsic tumor-targeting property and unique nanocage structure of human HFn, a broad variety of cargo-loaded HFn formulations have been developed for biological analysis, imaging diagnosis, and medicine development. In view of the intrinsic tumor-targeting property, unique nanocage structure, lack of immunogenicity, and definite in vivo behavior, human HFn holds promise to promote therapeutic drugs, di...
Source: Cell Research - August 20, 2021 Category: Cytology Authors: Ningning Song Jianlin Zhang Jiao Zhai Juanji Hong Chang Yuan Minmin Liang Source Type: research
