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Therapy: Immunotherapy
Nutrition: Fruit
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Total 66 results found since Jan 2013.
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer
Eur J Pharmacol. 2023 Aug 21:176007. doi: 10.1016/j.ejphar.2023.176007. Online ahead of print.ABSTRACTProstate cancer (PCa) is among the most commonly diagnosed solid cancers in male adults. However, most anti-angiogenic therapies and immunotherapies fail to achieve durable remission in advanced PCa. Integrative analysis indicated that Sema3A was negatively correlated with the pathological malignancy and was involved in angiogenesis, cell adhesion, and immune infiltrates in PCa. Sema3A significantly inhibited vascular endothelial growth factor (VEGFA)-induced colony formation, cell proliferation, and PD-L1 expression in PC...
Source: European Journal of Pharmacology - August 23, 2023 Category: Drugs & Pharmacology Authors: Ying Yu Xing Huang Chaoqi Liang Peng Zhang Source Type: research
Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy
Cell Death Dis. 2023 Feb 11;14(2):109. doi: 10.1038/s41419-022-05482-5.ABSTRACTLitchi chinensis seed, as a valuable by-product of the subtropical fruit litchi (Litchi chinensis Sonn.), has been confirmed to be rich in procyanidins (LPC). The anticarcinogenic properties of procyanidins has been primarily attributed to their antioxidant and anti-inflammatory activities. However, there is a comparative paucity of information on if and how LPC inhibits colon cancer. Here, LPC significantly inhibited CT26 colon cancer cells proliferation and metastasis in vivo and in vitro. In CT26 lung metastatic mice, the anti-metastatic effe...
Source: Cancer Control - February 11, 2023 Category: Cancer & Oncology Authors: Yuan Yao Suya Feng Xuejiao Li Taohua Liu Shengying Ye Long Ma Shuli Man Source Type: research
Predictive Biomarkers for Response to Immunotherapy in Triple Negative Breast Cancer: Promises and Challenges
J Clin Med. 2023 Jan 26;12(3):953. doi: 10.3390/jcm12030953.ABSTRACTTriple negative breast cancer (TNBC) is a highly heterogeneous disease with a poor prognosis and a paucity of therapeutic options. In recent years, immunotherapy has emerged as a new treatment option for patients with TNBC. However, this therapeutic evolution is paralleled by a growing need for biomarkers which allow for a better selection of patients who are most likely to benefit from this immune checkpoint inhibitor (ICI)-based regimen. These biomarkers will not only facilitate a better optimization of treatment strategies, but they will also avoid unne...
Source: Clinical Genitourinary Cancer - February 11, 2023 Category: Cancer & Oncology Authors: Xiaoxiao Wang Laetitia Collet Mattia Rediti V éronique Debien Alex De Caluw é David Venet Emanuela Romano Fran çoise Rothé Christos Sotiriou Laurence Buisseret Source Type: research
Immunomodulatory Role of Diospyros peregrina Fruit Preparation in Breast Cancer by Utilizing Macrophage Mediated Antigen Presentation and T Helper Cell (Th) Differentiation
CONCLUSION: The results collectively pointed out that DFP favored cell-mediated immune response from BTAA antigen presentation on macrophages and also helping in the robust proliferation of an entire spectrum of T helper lymphocytes which furthermore strengthen the underlying immune responses, hence, fencing the body, of the progression of breast cancer.PMID:36641322 | DOI:10.1016/j.clbc.2022.12.020
Source: Clinical Genitourinary Cancer - January 14, 2023 Category: Cancer & Oncology Authors: Akshaya M Surendran Akanksha Rai Sudeshna Rakshit Melvin George Koustav Sarkar Source Type: research
Oak pollen allergy in Korea
Curr Protein Pept Sci. 2022 Jun 24. doi: 10.2174/1389203723666220624141550. Online ahead of print.ABSTRACTOak pollen allergy is common all over the world and important causes of pollinosis. The molecular properties of some component allergens have been clearly characterized, while some of them are still waiting for the characterization. Studies on some oak component allergens are neglected, possibly because of its high cross-reactivity to birch. However, the utilization of culprit allergen molecules is expected to increase the diagnostic sensitivity and efficacy of immunotherapy. Sensitization to oak pollen along with birc...
Source: Current Protein and Peptide Science - June 24, 2022 Category: Biochemistry Authors: Kyoung Yong Jeong Jung-Won Park Source Type: research
Mangosteen Inhibits Growth and Survival of Cervical Cancer Cells
CONCLUSION: ME impedes the growth and survival of SiHa cervical cancer cells by down-regulating cyclin B, cyclin D, cyclin E as well as FLIP and survivin. ME may be a promising strategy for targeted cancer immunotherapy development.PMID:35641300 | DOI:10.21873/anticanres.15772
Source: Cell Research - May 31, 2022 Category: Cytology Authors: Nathan T Givens Lei Zhao Ziwen Zhu Marco Lequio Huaping Xiao Bradley D Johnson Qian Bai Mark R Wakefield Yujiang Fang Source Type: research
