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Total 868 results found since Jan 2013.

Latest insights on Food Protein-Induced Enterocolitis Syndrome: an emerging medical condition.
Abstract Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated gastrointestinal food hypersensitivity, characterized by profuse vomiting, frequently associated to pallor or/and lethargy that appears within 1 to 3 hours after ingestion of the offending food. There is a less frequent chronic form of FPIES, presenting with protracted vomiting, diarrhea or both, accompanied by poor growth. Although FPIES is considered a rare allergic disorder, in the last few years there have been an increasing number of reports about it indicating if not a real increase in incidence, at least an increased awarenes...
Source: Journal of Investigational Allergology and Clinical Immunology - August 29, 2017 Category: Allergy & Immunology Authors: Vila Sexto L Tags: J Investig Allergol Clin Immunol Source Type: research

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
We report many of them for the first time. For the already described citrullinated proteins MBP, GFAP, and vimentin, we could identify additional citrullinated sites. The number of modified proteins in MS white matter was higher than control tissue. Citrullinated peptides are considered neoepitopes that may trigger autoreactivity. We used newly identified epitopes and previously reported immunodominant myelin peptides in their citrullinated and non-citrullinated form to address the recognition of CSF-infiltrating CD4+ T cells from 22 MS patients by measuring proliferation and IFN-γ secretion. We did not detect ...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

An Integrated Approach to Unravel Hidradenitis Suppurativa Etiopathogenesis
Conclusions In this review, we collected all the information concerning the OMICs studies performed on HS patients aimed at unraveling the mechanisms at the basis of the disease or associated to clinical severity and/or the successful response to pharmacological treatment (including biological drugs). The general picture of the OMICs contribution in the context of HS is not so clear and/or rich of clinical useful information, since most of the studies focused only on one aspect (genome, transcriptome, or proteome) of the disease, enrolling small numbers of patients (this is quite limiting for the genetic studies) from di...
Source: Frontiers in Immunology - April 24, 2019 Category: Allergy & Immunology Source Type: research

Primary Prevention of Allergy - Is It Feasible?
Allergy Asthma Immunol Res. 2023 Jul;15(4):419-436. doi: 10.4168/aair.2023.15.4.419.ABSTRACTThe allergy epidemic has been attributed to environmental influences related to urbanization and the modern lifestyle. In this regard, various theories exploring the role of microbes (hygiene, old friends, microbiota, and biodiversity hypotheses), and the epithelial barrier (epithelial, dual allergen exposure and vitamin D hypotheses) have been proposed. These hypotheses have guided clinical studies that led to the formulation of intervention strategies during the proposed window of opportunity dubbed as the "first thousand days." T...
Source: Allergy, Asthma and Immunology Research - July 20, 2023 Category: Allergy & Immunology Authors: Pauline Poh-Lin Chan Ng Elizabeth Huiwen Tham Bee-Wah Lee Source Type: research