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Vaccination: Vaccines
Nutrition: Carbohydrates
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Total 231 results found since Jan 2013.
NMR chemical shift prediction and structural elucidation of linker-containing oligo- and polysaccharides using the computer program CASPER
Carbohydr Res. 2023 Sep 4;533:108937. doi: 10.1016/j.carres.2023.108937. Online ahead of print.ABSTRACTCarbohydrate structures containing alkyl groups as aglycones are useful for investigating enzyme activity and glycan-protein interactions. Moreover, linker-containing oligosaccharides with a spacer group are commonly used to print glycan microarrays or to prepare protein-conjugates as vaccine candidates. The structural accuracy of these synthesized glycans are essential for interpretation of results from biological experiments in which the compounds have been used and NMR spectroscopy can unravel and confirm their structu...
Source: Carbohydrate Research - September 21, 2023 Category: Genetics & Stem Cells Authors: Kevin M Dorst G öran Widmalm Source Type: research
Carbohydrates as putative pattern recognition receptor agonists in vaccine development
Trends Immunol. 2023 Sep 6:S1471-4906(23)00160-6. doi: 10.1016/j.it.2023.08.006. Online ahead of print.ABSTRACTAdjuvants are essential components of modern vaccines. One general mechanism underlying their immunostimulatory functions is the activation of pattern recognition receptors (PRRs) of innate immune cells. Carbohydrates - as essential signaling molecules on microbial surfaces - are potent PRR agonists and candidate materials for adjuvant design. Here, we summarize the latest trends in developing carbohydrate-containing adjuvants, with fresh opinions on how the physicochemical characteristics of the glycans (e.g., mo...
Source: Trends in Immunology - September 8, 2023 Category: Allergy & Immunology Authors: Ruoyu Mu Lei Dong Chunming Wang Source Type: research
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00517-w. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the i...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Marwa O El-Derany Diana M F Hanna John Youshia Enas Elmowafy Mohamed A Farag Samar S Azab Source Type: research
Glycovaccinology: The design and engineering of carbohydrate-based vaccine components
Biotechnol Adv. 2023 Aug 7:108234. doi: 10.1016/j.biotechadv.2023.108234. Online ahead of print.ABSTRACTVaccines remain one of the most important pillars in preventative medicine, providing protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of the many possible candidate antigens for subunit vaccine development, carbohydrates are particularly appealing because of their ubiquitous presence on the surface of all living cells, viruses, and parasites as well as their known interactions with both innate and adaptive immune cells. Indeed, several licensed vaccines leverage bacterial cell-su...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Sophia W Hulbert Primit Desai Michael C Jewett Matthew P DeLisa Asher J Williams Source Type: research
Genome-Wide Mining of < em > Selaginella moellendorffii < /em > for Hevein-like Lectins and Their Potential Molecular Mimicry with SARS-CoV-2 Spike Glycoprotein
Curr Issues Mol Biol. 2023 Jul 14;45(7):5879-5901. doi: 10.3390/cimb45070372.ABSTRACTMultidisciplinary research efforts on potential COVID-19 vaccine and therapeutic candidates have increased since the pandemic outbreak of SARS-CoV-2 in 2019. This search has become imperative due to the increasing emergences and limited widely available medicines. The presence of bioactive anti-SARS-CoV-2 molecules was examined from various plant sources. Among them is a group of proteins called lectins that can bind carbohydrate moieties. In this article, we present ten novel, chitin-specific Hevein-like lectins that were derived from Sel...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Ahmed Alsolami Amina I Dirar Emadeldin Hassan E Konozy Makarim El-Fadil M Osman Mohanad A Ibrahim Khalid Farhan Alshammari Fawwaz Alshammari Meshari Alazmi Kamaleldin B Said Source Type: research
