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Nutrition: Calcium
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Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signalling by lncRNA < em > Tug1 < /em > in cardiomyocytes
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00339.2023. Online ahead of print.ABSTRACTCardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca2+ levels and consists of pore-forming proteins including MCU, and various regulatory proteins such as mitochondrial calcium uptake proteins 1 and 2 (MICU1/2). The stoichiometry of these proteins influences the sensitivity to Ca2+ and activity of the complex. However, the factors that regulate their gene expression remain incompletely understood. Long non-coding RNAs (lncRNAs)...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Adam J Trewin Kate L Weeks Glenn D Wadley S éverine Lamon Source Type: research
Molecular docking analysis of calcium channel blockers with ALR2 and RAGE
We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery.PMID:37720280 | PMC:PMC10504517 | DOI:10.6026/97320630019028
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Samreen Kazmi Surekha Challa Malini Devi Alaparthi Indira Devi M Swetha Sudha Nagamalla Priya Ej Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Vitam Horm. 2023;123:313-383. doi: 10.1016/bs.vh.2022.12.008. Epub 2023 Jun 8.ABSTRACTThe nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex transcriptionally controls genes encoding factors that regulate calcium and phosphate sensing/transport, bone remodeling, immune function, and nervous system maintenance. With the aid of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), 1,25D/VDR primarily participates in an intricate netw...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Mark R Haussler Carol A Haussler Peter W Jurutka Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Vitam Horm. 2023;123:313-383. doi: 10.1016/bs.vh.2022.12.008. Epub 2023 Jun 8.ABSTRACTThe nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex transcriptionally controls genes encoding factors that regulate calcium and phosphate sensing/transport, bone remodeling, immune function, and nervous system maintenance. With the aid of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), 1,25D/VDR primarily participates in an intricate netw...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Mark R Haussler Carol A Haussler Peter W Jurutka Source Type: research
TORC1 mediated regulation of mitochondrial integrity and calcium ion homeostasis by Wat1/mLst8 in S. pombe
Int J Biol Macromol. 2023 Sep 15:126907. doi: 10.1016/j.ijbiomac.2023.126907. Online ahead of print.ABSTRACTThe mTOR complexes play a fundamental role in mitochondrial biogenesis and cellular homeostasis. Wat1, an ortholog of mammalian Lst8 is an important component of TOR complex and is essential for the regulation of downstream signaling. Earlier we reported the role of Wat1 in oxidative stress response. Here, we have shown that the abrogation of wat1 causes respiratory defects and mitochondrial depolarization that leads to a decrease in ATP production. The confocal and electron microscopy in wat1Δ cells revealed the fr...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Simmi Anjum Swati Srivastava Lalita Panigrahi Uzair Ahmad Ansari Arun Kumar Trivedi Shakil Ahmed Source Type: research
Insight into the mechanism of nutrients removal and response regulation of denitrifying phosphorus removal system under calcium ion stress
This study investigated the effects of calcium ion (Ca2+) on the nutrients removal, nitrogen oxide (N2O) release, microbial community, and quorum sensing in DPR system. Results showed that high accumulation of Ca2+ had a significant impact on the carbon footprint of DPR system. Specifically, N2O release reached 2.11 mg/L under Ca2+ of 150 mg/L, which represented 214.93% increase compared to 0 mg/L of Ca2+. The DPR system demonstrated its adaptability to elevated Ca2+ concentrations by modifying key enzyme activities involved in nitrogen and phosphorus removal, altering the microbial community structure, and adjusting the t...
Source: Bioresource Technology - September 17, 2023 Category: Biotechnology Authors: Cheng Han Hongliang Dai Zechong Guo Guangcan Zhu Bing Li Haq Nawaz Abbasi Xingang Wang Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Sirtuin1 inhibits calcium oxalate crystal-induced kidney injury by regulating TLR4 signaling and macrophage-mediated inflammatory activation
Cell Signal. 2023 Sep 15:110887. doi: 10.1016/j.cellsig.2023.110887. Online ahead of print.ABSTRACTSirtuin1 (Sirt1) activation significantly attenuated calcium oxalate (CaOx) crystal deposition and renal inflammatory injury by regulating renal immune microenvironment. Here, to elucidate the molecular mechanism underlying the therapeutic effects of Sirt1 on macrophage related inflammation and tubular epithelial cells (TECs) necrosis, we constructed a macrophage and CaOx monohydrate (COM)-stimulated tubular cell co-culture system to mimic immune microenvironment in kidney and established a mouse model of CaOx nephrocalcinosi...
Source: Cellular Signalling - September 17, 2023 Category: Cytology Authors: Chen Duan Haoran Liu Xiaoqi Yang Jianhe Liu Yaoliang Deng Tao Wang Jinchun Xing Zhiquan Hu Hua Xu Source Type: research
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Vitam Horm. 2023;123:313-383. doi: 10.1016/bs.vh.2022.12.008. Epub 2023 Jun 8.ABSTRACTThe nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex transcriptionally controls genes encoding factors that regulate calcium and phosphate sensing/transport, bone remodeling, immune function, and nervous system maintenance. With the aid of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), 1,25D/VDR primarily participates in an intricate netw...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Mark R Haussler Carol A Haussler Peter W Jurutka Source Type: research
Insight into the mechanism of nutrients removal and response regulation of denitrifying phosphorus removal system under calcium ion stress
This study investigated the effects of calcium ion (Ca2+) on the nutrients removal, nitrogen oxide (N2O) release, microbial community, and quorum sensing in DPR system. Results showed that high accumulation of Ca2+ had a significant impact on the carbon footprint of DPR system. Specifically, N2O release reached 2.11 mg/L under Ca2+ of 150 mg/L, which represented 214.93% increase compared to 0 mg/L of Ca2+. The DPR system demonstrated its adaptability to elevated Ca2+ concentrations by modifying key enzyme activities involved in nitrogen and phosphorus removal, altering the microbial community structure, and adjusting the t...
Source: Bioresource Technology - September 17, 2023 Category: Biotechnology Authors: Cheng Han Hongliang Dai Zechong Guo Guangcan Zhu Bing Li Haq Nawaz Abbasi Xingang Wang Source Type: research
Sirtuin1 inhibits calcium oxalate crystal-induced kidney injury by regulating TLR4 signaling and macrophage-mediated inflammatory activation
Cell Signal. 2023 Sep 15:110887. doi: 10.1016/j.cellsig.2023.110887. Online ahead of print.ABSTRACTSirtuin1 (Sirt1) activation significantly attenuated calcium oxalate (CaOx) crystal deposition and renal inflammatory injury by regulating renal immune microenvironment. Here, to elucidate the molecular mechanism underlying the therapeutic effects of Sirt1 on macrophage related inflammation and tubular epithelial cells (TECs) necrosis, we constructed a macrophage and CaOx monohydrate (COM)-stimulated tubular cell co-culture system to mimic immune microenvironment in kidney and established a mouse model of CaOx nephrocalcinosi...
Source: Cellular Signalling - September 17, 2023 Category: Cytology Authors: Chen Duan Haoran Liu Xiaoqi Yang Jianhe Liu Yaoliang Deng Tao Wang Jinchun Xing Zhiquan Hu Hua Xu Source Type: research
