• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

News at a glance: Muscular dystrophy therapy, lab-grown chicken, and humans ’ toll on wildlife
BIOMEDICINE Muscular dystrophy therapy approved The U.S. Food and Drug Administration has approved the first gene therapy for Duchenne muscular dystrophy (DMD), a genetic disease that cripples boys and usually results in death by age 30. The treatment from Sarepta Therapeutics introduces a short version of the gene for dystrophin, a crucial muscle protein, which is mutated in patients with DMD. A one-time intravenous infusion of a virus delivers the functioning “microdystrophin” gene into patients’ muscle cells. The 22 June approval is only for boys 4 to 5 years old, a group that appeared likely to ben...
Source: Science of Aging Knowledge Environment - June 29, 2023 Category: Geriatrics Source Type: research

Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs
This study was supported by NIH/NIAID grants R01AI102766 (YL), P01AI104722 (RW and YL), UM1 AI100663 (RW), and Bill and Melinda Gates Foundation grant OPP1084519 (RW). JS is a trainee of NIH training grant T32AI125186A to Anne Simon at University of Maryland, College Park. This study was also partially funded by the International AIDS Vaccine Initiative (IAVI) (RW) with the generous support of United States Agency for International Development (USAID), and Ministry of Foreign Affairs of the Netherlands. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or ...
Source: Frontiers in Microbiology - April 22, 2019 Category: Microbiology Source Type: research

Editorial: Orchestration of an Immune Response to Respiratory Pathogens
Steven M. Varga1 and Andrea J. Sant2* 1Microbiology and Immunology, University of Iowa, Iowa City, IA, United States2Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Rochester, NY, United States Editorial on the Research Topic Orchestration of an Immune Response to Respiratory Pathogens This issue of Frontiers deals with the complex series of events and long-term consequences of immune responses to respiratory pathogens. In this issue, the contributors discuss the earliest events following infection, the alternative paths that the adaptive immune response can take an...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study
Publication date: Available online 16 February 2017 Source:The Lancet Respiratory Medicine Author(s): Jason R Andrews, Elisa Nemes, Michele Tameris, Bernard S Landry, Hassan Mahomed, J Bruce McClain, Helen A Fletcher, Willem A Hanekom, Robin Wood, Helen McShane, Thomas J Scriba, Mark Hatherill Background The value of quantitative interferon-γ release assay results for predicting progression from Mycobacterium tuberculosis infection to active disease is unknown. We aimed to investigate the relation between QuantiFERON-TB Gold In-Tube (QFT) conversion interferon-γ values and risk of subsequent active tuberculosis disease ...
Source: The Lancet Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis
Publication date: Available online 20 February 2016 Source:The Lancet Respiratory Medicine Author(s): Timothy E Sweeney, Lindsay Braviak, Cristina M Tato, Purvesh Khatri Background Active pulmonary tuberculosis is difficult to diagnose and treatment response is difficult to effectively monitor. A WHO consensus statement has called for new non-sputum diagnostics. The aim of this study was to use an integrated multicohort analysis of samples from publically available datasets to derive a diagnostic gene set in the peripheral blood of patients with active tuberculosis. Methods We searched two public gene expression mic...
Source: The Lancet Respiratory Medicine - February 20, 2016 Category: Respiratory Medicine Source Type: research