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Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR)
This study was reviewed and approved by the Austin Health Human Research Ethics Committee (HREC/50791/Austin-19). Results will be published in peer-reviewed journals and presented at relevant conferences. Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12619000241134).
Source: BMJ Open - August 17, 2022 Category: General Medicine Authors: James, F., Goh, M. S. Y., Mouhtouris, E., Vogrin, S., Chua, K. Y. L., Holmes, N. E., Awad, A., Copaescu, A.-M., De Luca, J. F., Zubrinich, C., Gin, D., Cleland, H., Douglas, A., Kern, J. S., Katelaris, C. H., Thien, F., Barnes, S., Yun, J., Tong, W., Smit Tags: Open access, Immunology (including allergy) Source Type: research

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in proge...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells
Discussion Treg represent a lineage of T cells which play a fundamental role in maintaining humoral tolerance in the periphery. This subset of “suppressor T cells” is identified as FoxP3-expressing CD4+ T cells (16, 17). The unrestrained expression of FoxP3 is essential for the development and function of Treg (4). Accordingly, a disruption of the Foxp3 gene in scurfy mice results in an autoimmune lymphoproliferative disorder with fatal multi-organ inflammation (18). Since the causative mutation occurs in orthologous genes, the scurfy phenotype is indicated as the murine equivalent of the human IPEX sy...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis
Background: It is assumed that beside alterations in the filaggrin gene (FLG), disturbances within genes encoding other cornified envelope proteins are also involved in atopic dermatitis (AD). To identify new potential markers of AD, we studied the polymorphisms of genes encoding repetin (RPTN), cornulin (CRNN), and their expression in the skin of AD patients.Methods: Polymorphisms inCRNN(rs941934),RPTN (rs284544, rs28441202, rs3001978, and rs12117644), andFLG mutations (R2447X, S3247X) were analyzed by TaqMan genotyping assay and by PCR-RFLP in the blood samples of 159 AD patients and 108 healthy subjects. The expression ...
Source: International Archives of Allergy and Immunology - February 20, 2017 Category: Allergy & Immunology Source Type: research

How is Swimmer ’ s Itch Diagnosed?
Discussion Cercarial Dermatitis (CD) is known by many names throughout the world, but is commonly known as swimmer’s itch. It is a water-borne, non-communicable infectious disease that is caused by the larval stage (cercariae) of parasitic schistosomatid flukes. The cercariae causes an allergic maculopapular skin rash in humans that is usually self-limited (usually 4-10 days) but can cause problems for up to 20 days. CD parasites are considered an emerging disease because of the increased distribution of the problem across the globe. Different parasite species cause the problem. In a normal life cycle that occurs ma...
Source: PediatricEducation.org - November 7, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

No, You Don’t Have To Have Celiac Disease To Have A Wheat Sensitivity
People who don’t have a diagnosis for celiac disease or a wheat allergy may face a lot of scorn and derision for claiming to be sensitive to wheat products, skipping pasta and bread.  But a new study by scientists at Columbia University may explain why certain grain products can cause intestinal discomfort in some people, even if they don’t have a widely-recognized medical condition. It may also present doctors with a new way to test for this non-celiac wheat sensitivity, which for now has no diagnostic measure and must be assessed clinically, according to a person’s symptoms. Not everyone who feels ...
Source: Healthy Living - The Huffington Post - July 29, 2016 Category: Consumer Health News Source Type: news

Vasculitis after snorting cocaine contaminated with levamisole
Lawrence et al. Allergy Rhinol (Providence) 2014Copyright policy — open-access 3.5 out of 5 stars Cocaine-induced ecchymotic rash. Voore NK. Cleve Clin J Med 2016 Apr;3:252-253. Full Text Since at least 2010, a large percentage of cocaine samples seized in the United States has contained levamisole, a veterinary anti-worm medication. Levamisole had previously used in humans as an anti-helminthic and also in some chemotherapy regimens. It was withdrawn from the U.S. market in 1999 because of its association with agranulocytosis and vasculitis. It is apparently added to cocaine because it increases catecholamine release, ...
Source: The Poison Review - April 7, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cocaine levamisole vasculitis Source Type: news