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Impaired cytokine production of circulating immune cells in severe asthma in response to Influenza virus
Conclusion: Impaired cytokine responses to acute IAV infection could explain the increased susceptibility to IAV in asthma and the increase in inflammation in exacerbations. This implicates a systemic immunodeficiency leading to an impaired activation of circulating leukocytes after recruitment to the infected tissue.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Jamal Jameel, K., Yanik, S., Kamaci, C., Weidinger, D., Buelthoff, E., Rohde, S., Yusuf, F., Kronsbein, J., Tenbusch, M., Knobloch, J. Tags: 05.03 - Allergy and immunology Source Type: research

Enhanced early T cell activation and protection from hyper-inflammation in smoke exposed Cox4i2-/- infected mice with influenza
Respiratory virus infections are a major cause of concern in chronic obstructive pulmonary disease (COPD). Mitochondrial reactive oxygen species (mtROS) play an important role in immune function and increased mtROS levels may have an effect in COPD. Cox4i2 regulates ROS production at complex III and has been shown implicated in the development of emphysema.We hypothesize that Cox4i2–/– mice are protected from smoke-induced hyper-inflammation but also exhibit impaired T cell activation and antiviral immunity.We analyzed T cell subsets, BAL Albumin leakage and virus load via qPCR. C57BL/6 (WT) and Cox4i2–/&...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Berger, T., Garcia Castro, C. F., Lakshmi, V., Völkel, S., Sommer, N., Skevaki, C. Tags: 05.03 - Allergy and immunology Source Type: research

Racial and Ethnic Differences of Influenza-Associated Pediatric Hospitalizations and Deaths, 2008 –2017
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Source: Pediatric, Allergy, Immunology, and Pulmonology - April 29, 2022 Category: Respiratory Medicine Authors: Shelease C. O'Bryant Deepa Dongarwar Hamisu M. Salihu Susan Gillespie Source Type: research

The impact of COVID-19 on patients with asthma
Conclusion Patients with asthma and COVID-19 were older and at increased risk due to comorbidity-related factors. ICS and biologics are generally safe and may be associated with a protective effect against severe COVID-19 infection.
Source: European Respiratory Journal - March 4, 2021 Category: Respiratory Medicine Authors: Izquierdo, J. L., Almonacid, C., Gonzalez, Y., Del Rio-Bermudez, C., Ancochea, J., Cardenas, R., Lumbreras, S., Soriano, J. B. Tags: Respiratory infections and tuberculosis Original Articles: Pulmonary infections Source Type: research

Microbiome landscape and disease duration role in allergy in adult patients with bronchiectasis
Conclusions: 1) The study showed that a longer DD and chronic colonization by pathogens are associated with higher levels of TS IgE in pts with B. 2) The most common pathogens are PA and HI in pts with B in Dnipro.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Gashynova, K., Suska, K., Dmytrychenko, V. Tags: Allergy and immunology Source Type: research

Treatment with Omalizumab in adults with severe allergic reduces Fc?I expression on dendritic cells and improves antiviral responses
Conclusion: Adults with severe allergic asthma demonstrate impaired systemic DC immune responses to IAV and RV. Treatment with Omalizumab, that results in reduced exacerbations is associated with reduced DC FcI expression, enhanced DC IFN-α/ responses to viruses and this effect is seen within 4 weeks treatment.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wark, P., Nichol, K., Dorahy, D., Collison, A., Mattes, J. Tags: Allergy and immunology Source Type: research

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza
Conclusions Asthma is common in those hospitalised with influenza, but may not represent classical type 2-driven disease. Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes.
Source: European Respiratory Journal - October 23, 2019 Category: Respiratory Medicine Authors: Jha, A., Dunning, J., Tunstall, T., Thwaites, R. S., Hoang, L. T., The MOSAIC Investigators, Kon, O. M., Zambon, M. C., Hansel, T. T., Openshaw, P. J. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial
Publication date: Available online 30 September 2019Source: The Lancet Respiratory MedicineAuthor(s): John H Beigel, Evgenia Aga, Marie-Carmelle Elie-Turenne, Josalyn Cho, Pablo Tebas, Carol L Clark, Jordan P Metcalf, Caroline Ozment, Kanakatte Raviprakash, Joy Beeler, H Preston Holley, Stephanie Warner, Carla Chorley, H Clifford Lane, Michael D Hughes, Richard T Davey, John H Beigel, Evgenia Aga, Marie-Carmelle Elie-Turenne, Josalyn ChoSummaryBackgroundInfection with influenza virus causes substantial morbidity and mortality globally, although antiviral treatments are available. Previous studies have suggested that anti-i...
Source: The Lancet Respiratory Medicine - October 1, 2019 Category: Respiratory Medicine Source Type: research

Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study
In this study, influenza was found to be independently associated with invasive pulmonary aspergillosis (adjusted odds ratio 5·19; 95% CI 2·63–10·26; p<0·0001), along with a higher APACHE II score, male sex, and use of corticosteroids.InterpretationInfluenza was identified as an independent risk factor for invasive pulmonary aspergillosis and is associated with high mortality. Future studies should assess whether a faster diagnosis or antifungal prophylaxis could improve the outcome of influenza-associated aspergillosis.FundingNone.
Source: The Lancet Respiratory Medicine - August 1, 2018 Category: Respiratory Medicine Source Type: research

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures
Publication date: Available online 11 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Kenrie P Y Hui, Rachel H H Ching, Stan K H Chan, John M Nicholls, Norman Sachs, Hans Clevers, J S Malik Peiris, Michael C W ChanSummaryBackgroundHuman airway organoids are three-dimensional cultures derived from stem cells, which self-organise in ex-vivo conditions to form so-called mini-airways. The cellular morphology of these cultures is physiologically similar to the human airway, with cilia, goblet cells, and club cells facing the inner lumen and basal cells situated at the outer layer. The aim of this study was to compare...
Source: The Lancet Respiratory Medicine - July 12, 2018 Category: Respiratory Medicine Source Type: research

Clinical and microbiological status in asthmatic preschool children during a severe exacerbation: the VIRASTHMA 2 study
Conclusion: We confirmed the severe intermittent asthma phenotype, characterized by atopic features. Severe Ex were triggered by viruses (hRV), frequently associated with bacteria. Virus carriage was observed at steady state. Despite maintenance treatment with ICS, control was frequently not obtained.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lejeune, S., Gosset, P., Engelman, I., Dewilde, A., Dessein, R., Pouessel, G., Ducoin, H., Mitha, S., Delvart, C., Boileau, S., Le Mee, A., Bonnel, C., Thumerelle, C., Mordacq, C., Pichavant, M., Deschildre, A. Tags: Paediatric Respiratory Infection and Immunology Source Type: research

Late Breaking Abstract - IL-33 drives influenza-induced exacerbations of asthma by halting anti-viral and Th1 responses
Conclusion: Blocking IL33 attenuates virus-induced airway inflammation in HDM-sensitized and naïve mice, but does not affect AHR. IL-33 attenuates the anti-viral and Th1 responses, which result in a prolonged inflammation that leads to asthma exacerbations.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ravanetti, L., Dijkhuis, A., Sabogal Pineros, Y., Lutter, R. Tags: Allergy and immunology Source Type: research

Th22 cells develop independently of the Th17 lineage with unique transcriptional properties and plasticity toward Th1-type cells during Influenza infection
Introduction: Interleukin (IL)-22 is expressed in mucosal tissues during infections and chronic inflammatory diseases (e.g asthma and COPD). Th22 cells are a major source of IL-22 and have been identified in inflammatory infiltrates in patients suffering from asthma, cystic fibrosis, COPD, and RSV infection. However, their molecular characteristics and functional roles remain largely unknown.Results: We have generated novel dual IL-22/IL-17A reporter mice to identify, isolate and characterise Th17 and Th22 cells in vitro and in vivo. We have further identified a new differentiation assay to generate large numbers of Th22 c...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Plank, M., Kaiko, G., Maltby, S., Weaver, J., Tay, H., Wei, S., Wilson, M., Durum, S., Foster, P. Tags: Allergy and immunology Source Type: research

Factors influencing on influenza vaccination among south korean adult asthma: a nationwide population-based cross-section study
Conclusions: Attention and interventions are required to improve the influenza vaccination coverage for the non-elderly patients with asthma, especially on those who are taking no regular exercise, thinking self as being healthy, taking irregular health check-up.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Han, C. H., Chung, J. H. Tags: Allergy and immunology Source Type: research

A 58-Year-Old Woman With Pneumonia and Gram-Negative Diplococci.
Abstract CASE PRESENTATION: A 58-year-old woman with COPD, cor pulmonale, diabetes, and hypertension had a productive cough of greenish and purulent sputum, low-grade fever, and shortness of breath. Medications were metformin, losartan, cholecalciferol, folic acid, a multivitamin, fluticasone by inhalation, and, as needed, ipratropium by inhalation. She lived alone and worked as a physician, had received that year's seasonal influenza vaccine, was a heavy smoker, did not drink alcohol or use illicit drugs, and had no personal or family history of allergy and autoimmunity. PMID: 28991556 [PubMed - in process]
Source: Chest - October 1, 2017 Category: Respiratory Medicine Authors: Famularo G, Sordillo P, Stasolla A, Parisi MG Tags: Chest Source Type: research

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