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Blocking neddylation elicits antiviral effect against hepatitis B virus replication
CONCLUSION: The manipulation of the neddylation pathway can thus provide new tools interfering with HBV persistence as well as novel therapeutic strategies against chronic hepatitis B.PMID:34716866 | DOI:10.1007/s11033-021-06886-w
Source: Mol Biol Cell - October 30, 2021 Category: Molecular Biology Authors: Karima Abounouh Mohammad Enamul Hoque Kayesh Haya Altawalah Bouchra Kitab Shuko Murakami Shintaro Ogawa Yasuhito Tanaka Hind Dehbi Pascal Pineau Michinori Kohara Soumaya Benjelloun Kyoko Tsukiyama-Kohara Sayeh Ezzikouri Source Type: research

HBx combined with AFB1 triggers hepatic steatosis via COX-2-mediated necrosome formation and mitochondrial dynamics disorder.
Abstract Hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) exposure have been recognized as independent risk factors for the occurrence and exacerbation of hepatic steatosis but their combined impacts and the potential mechanisms remain to be further elucidated. Here, we showed that exposure to AFB1 impaired mitochondrial dynamics and increased intracellular lipid droplets (LDs) in the liver of HBV-transgenic mice in vivo and the hepatitis B virus X protein (HBx)-expressing human hepatocytes both ex vivo and in vitro. HBx combined with AFB1 exposure also up-regulated receptor interaction protein 1 (RIP1), ...
Source: J Cell Mol Med - July 6, 2019 Category: Molecular Biology Authors: Chen YY, Lin Y, Han PY, Jiang S, Che L, He CY, Lin YC, Lin ZN Tags: J Cell Mol Med Source Type: research

Hepatitis B virus X protein increases microRNA ‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway.
Hepatitis B virus X protein increases microRNA‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway. Mol Med Rep. 2017 Mar 23;: Authors: Hou Z, Quan J Abstract Hepatitis B virus (HBV) X protein (HBx) is a key regulatory protein that is involved in HBV infection, replication and carcinogenesis of hepatocellular carcinoma (HCC). The aim of the present study was to investigate the role of HBx in the progression and metastasis of liver cancer cells and to determine the underlying molecular mechanism...
Source: Molecular Medicine Reports - March 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Crosstalk between different family members: IL27 recapitulates IFN γ responses in HCC cells, but is inhibited by IL6-type cytokines
In this study, we show that IL27 induces STAT1 and STAT3 phosphorylation in 5 HCC lines and 3 different types of non-transformed liver cells. We were especially interested in the relevance of the IL27-induced STAT3 activation in liver cells. Thus, we compared the IL27 responses with those induced by IFNγ (STAT1-dominated response) or IL6-type cytokines (IL6, hyper-IL6 (hy-IL6) or OSM) (STAT3-dominated response) by microarray analysis and find that in HCC cells, IL27 induces an IFNγ-like, STAT1-dependent transcriptional response, but we do not find an effective STAT3-dependent response. Validation experiments corroborate ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 9, 2016 Category: Molecular Biology Source Type: research

Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis
Conclusion We provide a novel role of Stat3 cooperating TGF-β1 in activation and anti-apoptotic effect of HSCs. Stat3 worsens liver fibrosis through the up-regulation of TGF-β1 and fibrotic product expression.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 13, 2014 Category: Molecular Biology Source Type: research