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The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria
This study was conducted in the rural village of Kalifabougou, Mali where intense P. falciparum transmission occurs from June to December each year. Isolation of Tonsil B Cells Tonsils were mechanically disrupted in complete RPMI (RPMI 1640 with L-glutamine supplemented with 10% heat-inactivated FBS, 1 mM sodium pyruvate, 1% MEM nonessential amino acids, 50 μM 2-mercaptoethanol, 100 U/ml penicillin, 100 μg/ml streptomycin, and 25 mM HEPES, pH 7.2–7.5 [all from GIBCO, Invitrogen]) and passed through a 70-μm cell strainer to make a single cell suspension. B cells were then negatively selecte...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research

Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations
Penicillium marneffei is a pathogenic fungus endemic in Southeast Asia. P marneffei was an extremely rare pathogen in humans before the HIV epidemic, but following the exponential rise in the prevalence of HIV in Southeast Asia, penicilliosis emerged as a clinically significant opportunistic infection and is classified as an AIDS-defining illness. Less commonly, penicilliosis occurs in patients with other immunodeficiencies, such as severe combined immunodeficiency, common variable immunodeficiency, hyper-IgM syndrome, hyper-IgE syndrome, the presence of anti-IFN-γ autoantibody, diabetes mellitus, immunosuppressive therap...
Source: Journal of Allergy and Clinical Immunology - November 4, 2013 Category: Allergy & Immunology Authors: Pamela P.W. Lee, Huawei Mao, Wanling Yang, Koon-Wing Chan, Marco H.K. Ho, Tsz-Leung Lee, Jasper F.W. Chan, Patrick C.Y. Woo, Wenwei Tu, Yu-Lung Lau Tags: Letters to the Editor Source Type: research