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Policy Implications of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe
Am J Trop Med Hyg. 2022 Oct 11;107(4_Suppl):68-74. doi: 10.4269/ajtmh.21-1288. Print 2022 Oct 11.ABSTRACTThe International Centers of Excellence for Malaria Research (ICEMR) were established by the National Institute of Allergy and Infectious Diseases more than a decade ago to provide multidisciplinary research support to malaria control programs worldwide, operating in endemic areas and contributing technology, expertise, and ultimately policy guidance for malaria control and elimination. The Southern and Central Africa ICEMR has conducted research across three main sites in Zambia and Zimbabwe that differ in ecology, ent...
Source: Am J Trop Med Hyg - October 13, 2022 Category: Infectious Diseases Authors: Amy Wesolowski Matthew M Ippolito Mary E Gebhardt Ellen Ferriss Jessica L Schue Tamaki Kobayashi Mike Chaponda Jean-Bertin Kabuya Mbanga Muleba Monicah Mburu Japhet Matoba Michael Musonda Ben Katowa Mukuma Lubinda Harry Hamapumbu Limonty Simubali Twig Mud Source Type: research

A point-of-care cassette test for detection of Strongyloides stercoralis
Acta Trop. 2021 Nov 19:106251. doi: 10.1016/j.actatropica.2021.106251. Online ahead of print.ABSTRACTStrongyloides stercoralis is a parasite that causes strongyloidiasis worldwide. It may lead to a life-long infection in immunocompetent people and hyperinfection in immunosuppressed patients. A point-of-care (POC) rapid test is helpful for patient diagnosis in resource-limited settings and as a detection tool in elimination/control programs. Previously, we reported a rapid IgG4 dipstick test (SsRapid®) for Strongyloides suitable for a laboratory setting. A POC cassette format of the test, which is field-applicable, has sin...
Source: Acta Tropica - November 22, 2021 Category: Infectious Diseases Authors: R Noordin E Osman N Kalantari N S Anuar T Gorgani-Firouzjaee P Sithithaworn N M Juri A Rahumatullah Source Type: research

Investigational malaria vaccine gives strong, lasting protection
(NIH/National Institute of Allergy and Infectious Diseases) Two U.S. Phase 1 clinical trials of a novel candidate malaria vaccine have found that the regimen conferred unprecedentedly high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites. The vaccine combines live parasites with either of two widely used antimalarial drugs -- an approach termed chemoprophylaxis vaccination. A Phase 2 clinical trial of the vaccine is now underway in Mali, a malaria-endemic country.
Source: EurekAlert! - Infectious and Emerging Diseases - June 30, 2021 Category: Infectious Diseases Source Type: news

Study vaccine protects monkeys against four types of hemorrhagic fever viruses
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed an investigational vaccine that protected cynomolgus macaques against four types of hemorrhagic fever viruses endemic to overlapping regions in Africa. The University of Texas Medical Branch in Galveston and Profectus BioSciences of New York are developing and testing the candidate quadrivalent VesiculoVax vaccine, with support from NIH's National Institute of Allergy and Infectious Diseases (NIAID) and Redeemer's University in Nigeria.
Source: EurekAlert! - Infectious and Emerging Diseases - November 8, 2019 Category: Infectious Diseases Source Type: news

Sushi, cervice and gnathostomiasis - A case report and review of imported infections
We describe a case of imported cutaneous gnathostomiasis in a Thai patient living in France. Gnathostomiasis is a zoonosis of food origin. The disease is endemic in Southeast Asia and Latin America. However, over the past 30 years, an increasing number of imported cases has been described in Europe and America. The disease is rare in Western Europe and the majority of cases described had a cutaneous clinical presentation. The disease may sometimes be confused with allergy, leading to a delay in diagnosis.
Source: Travel Medicine and Infectious Disease - October 16, 2017 Category: Infectious Diseases Authors: Jordan Leroy, Marjorie Cornu, Anne Sophie Deleplancque, S éverine Loridant, Emmanuel Dutoit, Boualem Sendid Source Type: research

Sushi, ceviche and gnathostomiasis - A case report and review of imported infections
We describe a case of imported cutaneous gnathostomiasis in a Thai patient living in France. Gnathostomiasis is a zoonosis of food origin. The disease is endemic in Southeast Asia and Latin America. However, over the past 30 years, an increasing number of imported cases has been described in Europe and America. The disease is rare in Western Europe and the majority of cases described had a cutaneous clinical presentation. The disease may sometimes be confused with allergy, leading to a delay in diagnosis.
Source: Travel Medicine and Infectious Disease - October 16, 2017 Category: Infectious Diseases Authors: Jordan Leroy, Marjorie Cornu, Anne Sophie Deleplancque, S éverine Loridant, Emmanuel Dutoit, Boualem Sendid Source Type: research

NIAID officials call for continued Zika research
(NIH/National Institute of Allergy and Infectious Diseases) Although cases of Zika virus infection appear to be decreasing, the mosquito-borne virus likely will become endemic in the Americas. Given the serious complications of Zika virus infection, researchers must continue their work to better understand how the virus causes disease and to develop effective vaccines and treatments, according to a new article, by Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Disease (NIAID), and colleague Catharine I. Paules, M.D.
Source: EurekAlert! - Infectious and Emerging Diseases - January 13, 2017 Category: Infectious Diseases Source Type: news

Dengue vaccines: Are they safe for travelers?
The four dengue viruses (DENV) circulate among nearly one-half of the world's population in tropical and semitropical countries imposing a huge morbidity burden on travelers. Sanofipasteur has developed a tetravalent live-attenuated vaccine, Dengvaxia, recently approved by the World Health Organization and licensed in four dengue-endemic countries. An additional two dengue vaccines, developed by the National Institute of Allergy and Infectious Diseases (NIAID), USA and Takeda, are entering phase III testing.
Source: Travel Medicine and Infectious Disease - June 21, 2016 Category: Infectious Diseases Authors: Scott B. Halstead, Maira Aguiar Tags: Commentary Source Type: research

Malaria Diagnosis Across the International Centers of Excellence for Malaria Research: Platforms, Performance, and Standardization.
Abstract Diagnosis is "the act of identifying a disease, illness, or problem by examining someone or something." When an individual with acute fever presents for clinical attention, accurate diagnosis leading to specific, prompt treatment often saves lives. As applied to malaria, not only individual patient diagnosis is important but also assessing population-level malaria prevalence using appropriate diagnostic methods is essential for public health purposes. Similarly, identifying (diagnosing) fake antimalarial medications prevents the use of counterfeit drugs that can have disastrous effects. Therefore, accurat...
Source: Am J Trop Med Hyg - August 10, 2015 Category: Infectious Diseases Authors: Kobayashi T, Gamboa D, Ndiaye D, Cui L, Sutton P, Vinetz JM Tags: Am J Trop Med Hyg Source Type: research

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