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The use of specific immunoglobulin E in nasal secretions for the diagnosis of allergic rhinitis
ConclusionsIgE level in nasal secretions of subjects with rhinitis is a reliable noninvasive alternative to serum sIgE for diagnosis of allergic rhinitis. Level of Evidence4. Laryngoscope, 2018
Source: The Laryngoscope - February 1, 2018 Category: ENT & OMF Authors: Yifan Meng, Hongfei Lou, Yang Wang, Chengshuo Wang, Luo Zhang Tags: Allergy/Rhinology Source Type: research

Role of fungi in chronic rhinosinusitis through ITS sequencing
ConclusionFungal biomass estimated through ITS amplicon concentration correlated with traditional fungal detection techniques and CT double densities. Our results suggest that fungal dysbiosis only occurs in the sinuses of a selected subset of patients, and therefore could not be a universal determinant of sinus disease pathogenesis in all CRS patients. Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - July 1, 2017 Category: ENT & OMF Authors: Yi Chen Zhao, Ahmed Bassiouni, Kangsadarn Tanjararak, Sarah Vreugde, Peter ‐John Wormald, Alkis James Psaltis Tags: Allergy/Rhinology Source Type: research

Chronic invasive fungal sinusitis associated with intranasal drug use
We report a case of CIFS in an otherwise healthy young adult associated with intranasal illicit drug abuse. The patient presented with nonhealing nasal septal and palatal perforations. Biopsy demonstrated invasive Aspergillus flavus requiring surgical debridement and extended intravenous antifungal therapy. Tissue necrosis and ulceration related to intranasal drug use should be recognized as a potential risk factor for invasive fungal sinusitis. Laryngoscope, 2015
Source: The Laryngoscope - July 7, 2015 Category: ENT & OMF Authors: Kelly R. Pekala, Matthew J. Clavenna, Ross Shockley, Vivian L. Weiss, Justin H. Turner Tags: Allergy/Rhinology Source Type: research

Superoxide dismutase reduces the inflammatory response to Aspergillus and Alternaria in human sinonasal epithelial cells derived from patients with chronic rhinosinusitis.
CONCLUSIONS: When HSNECs from CRSwNP patients are treated with SOD concurrently with Aspergillus or Alternaria, SOD treatment decreases the fungal antigen-induced inflammatory response. The ability to attenuate inflammation induced by common fungal allergens with SOD treatment could provide a novel therapeutic or preventative approach for patients with CRS or other allergic inflammatory airway diseases. PMID: 25785747 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - March 1, 2015 Category: ENT & OMF Authors: Lawrence LA, Mulligan JK, Roach C, Pasquini WN, Soler ZM, Banglawala SM, Karnezis TT, Gudis DA, Schlosser RJ Tags: Am J Rhinol Allergy Source Type: research

Clinical and allergic sensitization characteristics of allergic rhinitis among the elderly population in Istanbul, Turkey
Abstract Prevalence of allergic rhinitis (AR) in elderly population in Turkey is not known. Studies on the prevalence and features of allergy in older adults are needed to identify safe and effective diagnostic/therapeutic methods for elderly AR patients. We aimed to identify the clinical and allergic characteristics of sensitization to aeroallergens among individuals aged ≥60 years with allergic rhinitis admitted to an allergy outpatient clinic in Istanbul. Of 109 patients, 33.9 % were atopic. Sixty-five percent of subjects were sensitized to Dermatophagoides pteronyssinus, 17 % to a grass-pollen mixture, 8�...
Source: European Archives of Oto-Rhino-Laryngology - February 13, 2015 Category: ENT & OMF Source Type: research

Prognostic factors for survival in patients with acute invasive fungal rhinosinusitis.
CONCLUSIONS: Overall survival rate remained approximately 50% in patients with AIFR. The prognosis of AIFR is significantly influenced by underlying diseases, accompanying neutropenia, CRP levels, symptom duration, involvement of septum, and the presence of facial swelling. Elevation of CRP, in particular, was an independent predictor of poor outcomes and should be monitored appropriately. PMID: 25590320 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2015 Category: ENT & OMF Authors: Cho HJ, Jang MS, Hong SD, Chung SK, Kim HY, Dhong HJ Tags: Am J Rhinol Allergy Source Type: research

Development of Aspergillus protease with ovalbumin-induced allergic chronic rhinosinusitis model in the mouse.
CONCLUSION: Aspergillus protease combined with OVA induced more severe allergic inflammation in sinonasal mucosa compared with OVA alone and similar eosinophilia. This model could be more relevant to recalcitrant eosinophilic CRS in humans than OVA-induced allergic CRS. PMID: 25514482 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2014 Category: ENT & OMF Authors: Kim JH, Yi JS, Gong CH, Jang YJ Tags: Am J Rhinol Allergy Source Type: research

A novel model of invasive fungal rhinosinusitis in rats.
CONCLUSION: A rat IFRS model was successfully developed through nasal obstruction, CPA-induced neutropenia, and fungal inoculation. The disease modelclosely mimics the pathophysiology of anthropic IFRS. PMID: 23816783 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - June 21, 2013 Category: ENT & OMF Authors: Zhang F, An Y, Li Z, Zhao C Tags: Am J Rhinol Allergy Source Type: research

Invasive Fungal Rhinosinusitis
ConclusionsDSS and OS remain low for patients with AIFR. Extensive surgical resection in patients with these poor prognostic signs should be considered carefully in light of their poor survival. Long‐term survivors are at significant risk of sinonasal complications and should be followed closely. Level of Evidence4. Laryngoscope, 2012
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Marcus M. Monroe, Max McLean, Nathan Sautter, Mark K. Wax, Peter E. Andersen, Timothy L. Smith, Neil D. Gross Tags: Allergy/Rhinology Source Type: research