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Source: Frontiers in Immunology

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Total 269 results found since Jan 2013.

Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy
Benjamin L. Wright, Nielsen Q. Fernandez-Becker, Neeraja Kambham, Natasha Purington, Dana Tupa, Wenming Zhang, Matthew A. Rank, Hirohito Kita, Kelly P. Shim, Bryan J. Bunning, Alfred D. Doyle, Elizabeth A. Jacobsen, Scott D. Boyd, Mindy Tsai, Holden Maecker, Monali Manohar, Stephen J. Galli, Kari C. Nadeau, R. Sharon Chinthrajah
Source: Frontiers in Immunology - November 22, 2018 Category: Allergy & Immunology Source Type: research

Regulatory Immune Mechanisms in Tolerance to Food Allergy
Pattraporn Satitsuksanoa, Kirstin Jansen, Anna G łobińska, Willem van de Veen, Mübeccel Akdis
Source: Frontiers in Immunology - December 12, 2018 Category: Allergy & Immunology Source Type: research

Germ-Free Mice Exhibit Mast Cells With Impaired Functionality and Gut Homing and Do Not Develop Food Allergy
Martin Schwarzer, Petra Hermanova, Dagmar Srutkova, Jaroslav Golias, Tomas Hudcovic, Christian Zwicker, Marek Sinkora, Johnnie Akg ün, Ursula Wiedermann, Ludmila Tuckova, Hana Kozakova, Irma Schabussova
Source: Frontiers in Immunology - February 12, 2019 Category: Allergy & Immunology Source Type: research

Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy
Uta Jappe, Christian Schwager, Andra B. Schromm, Nestor Gonz ález Roldán, Karina Stein, Holger Heine, Katarzyna A. Duda
Source: Frontiers in Immunology - February 14, 2019 Category: Allergy & Immunology Source Type: research

Gut Microbiome as Target for Innovative Strategies Against Food Allergy
Roberto Berni Canani, Lorella Paparo, Rita Nocerino, Carmen Di Scala, Giusy Della Gatta, Ylenia Maddalena, Aniello Buono, Cristina Bruno, Luana Voto, Danilo Ercolini
Source: Frontiers in Immunology - February 15, 2019 Category: Allergy & Immunology Source Type: research

Fc γR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming
This study was done according to the ethical guidelines of the Academic Medical Center and human material was obtained in accordance with the AMC Medical Ethics Review Committee according to the Medical Research Involving Human Subjects Act. Buffy coats obtained after blood donation (Sanquin blood supply) are not subjected to informed consent, which is according to the Medical Research Involving Human Subjects Act and the AMC Medical Ethics Review Committee. All samples were handled anonymously. Ethical review and approval was not required for this study in accordance with the local legislation. Monocytes were isolated fro...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function
Conclusions The sheer number of factors to consider when translating observations between macaques and humans makes the process a challenging, multidimensional one. Differences in the structures and activities of IgG subclasses, and polymorphisms in protein sequence and post-translational modification of antibody receptors are a subset of the many relevant considerations. Copy number variation, splice variants, and alleles with sequence variation outside of coding regions have been associated with a diversity of phenotypes in humans (183, 213–217), and are presumed to exist in NHP. A number of differences in the p...
Source: Frontiers in Immunology - April 7, 2019 Category: Allergy & Immunology Source Type: research

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis
In conclusion, our data indicates that pDC have a protective role in limiting bacterial load in the gut and helping to maintain the intestinal barrier. As C. rodentium is closely related to the attaching and effacing human pathogens EPEC/EHEC, our work suggests that pDC may also play a role in protection from these organisms. More generally, a role for pDC in maintenance of the gut mucosal barrier and perhaps gut homeostasis would mean these cells may be important in protection from many human gut pathogens. pDC also appeared to regulate the systemic inflammatory response to pathogens released from the gut. Although pDC-de...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

NF- κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
Conclusions NF-κB is a master regulator of innate immune responses, and vital to many of the roles that macrophages and other innate immune cells play in orchestrating the inflammatory response to pathogens. In this review, we have outlined the many variables that influence the outcomes of NF-κB signaling, including those that are cell-, tissue-, and stimulus-specific. Over 30 years of research has illuminated the dynamics of this signaling pathway and the genes that are regulated by it, leading to many breakthroughs in how we understand NF-κB function. However, much of this information has come fr...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Editorial: Orchestration of an Immune Response to Respiratory Pathogens
Steven M. Varga1 and Andrea J. Sant2* 1Microbiology and Immunology, University of Iowa, Iowa City, IA, United States2Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Rochester, NY, United States Editorial on the Research Topic Orchestration of an Immune Response to Respiratory Pathogens This issue of Frontiers deals with the complex series of events and long-term consequences of immune responses to respiratory pathogens. In this issue, the contributors discuss the earliest events following infection, the alternative paths that the adaptive immune response can take an...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients
This study was approved by our local ethical review committee in compliance with the declaration of Helsinki. Informed and written consent was obtained from all patients (Ethic Committee Charité University Medicine, Berlin, Germany, EA2/028/13). The study cohort consisted of 7 kidney transplant recipients with sustained BKV reactivation (Table 1). The HLA typing for each patient and donor is summarized in Figure 1. TABLE 1 Table 1. Characteristics of patients with BKV reactivation. FIGURE 1 Figure 1. Recipient and donor HLA type. HLA type of the patients and their kidney donors. Black square i...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection
In this study we found blocking autophagy led to increased CP growth in both macrophages and mouse embryonic fibroblasts. In vivo, loss of the autophagy elongation component ATG16L1 specifically in myeloid cells led to increased mortality in response to CP infection, characterized by greater numbers of neutrophils and dendritic cells, but no change in the CP burden in the lungs. This was accompanied by an increase in inflammasome-active macrophages and IL-1β production. While induction of autophagy in macrophages led to reduced CP growth in vitro, in vivo treatment with rapamycin led to increased mortality of infec...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice
Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages
This study has been funded by the Council of Scientific and Industrial Research (CSIR), New Delhi, India, vide grant no 37 (1542)/12/EMR-II and Department of Science and Technology (DST-SERB), New Delhi, India, vide grant no EMR/2016/000854. It was also supported by Institute of life sciences, Bhubaneswar, under Department of Biotechnology and National Institute of Science Education and Research (NISER), Bhubaneswar, under Department of Atomic Energy (DAE), Government of India. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships th...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research