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Total 442 results found since Jan 2013.

The involvement of hormone-sensitive lipase in all-trans retinoic acid induced cleft palate
Int J Dev Biol. 2022;66(7-8-9):383-389. doi: 10.1387/ijdb.220137kz.ABSTRACTAbnormally high concentrations of all-trans retinoic acid (atRA) induce cleft palate, which is accompanied by abnormal migration and proliferation of mouse embryonic palatal mesenchyme (MEPM) cells. Hormone-sensitive lipase (HSL) is involved in many embryonic development processes. The current study was designed to elucidate the mechanism of HSL in cleft palate induced by atRA. To establish a cleft palate model in Kunming mice, pregnant mice were administered atRA (70 mg/kg) by gavage at embryonic Day 10.5 (E10.5). Embryonic palates were obtained th...
Source: International Journal of Developmental Biology - January 23, 2023 Category: Biology Authors: K Zheng Q N Ye Source Type: research

ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling
In this study, we explore the role of Rab26 in CS exposure modulating the inflammatory response of airway epithelium and the novel mechanism of CS exposure regulation Rab26. These data showed that CS exposure and H2O2 (a type of ROS) suppressed the expression of Rab26 and increased the expression of DNMT3b in vivo and in vitro. GEO data analysis found the level of Rab26 was decreased in the lung tissue of COPD patients. CSE-induced ROS promoted DNA methylation of the Rab26 promoter and inhibited its promoter activity by elevating the DNMT3b level. Antioxidants N-Acetyl-l-cysteine (NAC), 5-Aza-2'-deoxycytidine (5-AZA) (DNA ...
Source: Free Radical Biology and Medicine - January 7, 2023 Category: Biology Authors: Bin-Feng He Yi-Xing Wu Wei-Ping Hu Jian-Lan Hua Yaoping Han Jing Zhang Source Type: research

Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease
In conclusion, our findings confirmed that CAV1 exerts a protective effect against vascular injury by inhibiting oxidative stress and inflammation through the PKC/MAPK pathway. Therefore, restoration of CAV1 may have clinical benefits in reducing APAP-induced vascular damage in NAFLD patients.PMID:36596386 | DOI:10.1016/j.freeradbiomed.2022.12.095
Source: Free Radical Biology and Medicine - January 3, 2023 Category: Biology Authors: Dongdong Fu Shuai Wu Xiangfu Jiang Tingyu You Yu Li Jiao Xin Xiaowen Feng Jiagen Wen Yan Huang Chengmu Hu Source Type: research

A fast lasso-based method for inferring higher-order interactions
by Kieran Elmes, Astra Heywood, Zhiyi Huang, Alex Gavryushkin Large-scale genotype-phenotype screens provide a wealth of data for identifying molecular alterations associated with a phenotype. Epistatic effects play an important role in such association studies. For example, siRNA perturbation screens can be used to identify combinatorial gene-silencing effects. In bacteria, epistasis has practical consequences in determining antimicrobial resistance as the genetic background of a strain plays an important role in determining resistance. Recently developed tools scale to human exome-wide screens for pairwise interactions,...
Source: PLoS Computational Biology - December 29, 2022 Category: Biology Authors: Kieran Elmes Source Type: research

Alternative splicing of a carboxyl/choline esterase gene enhances the fenpropathrin tolerance of Tetranychus cinnabarinus
This article is protected by copyright. All rights reserved
Source: Insect Science - December 22, 2022 Category: Biology Authors: Peng Wei, Xinying Zeng, Haonan Han, Yiqing Yang, Youjun Zhang, Lin He Tags: ORIGINAL ARTICLE Source Type: research

SIRT3 Promotes the Development of Esophageal Squamous Cell Carcinoma by Regulating Hexokinase 2 through the AKT Signaling Pathway
In the present study, we explored whether sirtuin-3 (SIRT3) regulates the proliferation and migration of esophageal squamous cell carcinoma (ESCC) and investigated the mechanisms underlying the oncogene role of SIRT3. siRNA was used to transfect Eca109 cells and downregulate SIRT3. The proliferation and migration of Eca109 cells were examined by the CCK-8 assay, colony formation assay, Transwell assay, and scratch test. Quantitative real-time PCR and Western blotting were used to detect SIRT3, hexokinase 2, AKT, and p-AKT in Eca109 cells. Functional assays showed that downregulation of SIRT3 could inhibit the proliferation...
Source: Bulletin of Experimental Biology and Medicine - November 28, 2022 Category: Biology Source Type: research

Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling
In conclusion, SIRT7 alleviates renal ferroptosis, lipid peroxidation, and partial EMT under hypertensive status by facilitating the KLF15/Nrf2 signaling, thereby mitigating renal fibrosis, injury and dysfunction. Targeting SIRT7 signaling serves as a promising strategy for hypertension and hypertensive renal injury.PMID:36334846 | DOI:10.1016/j.freeradbiomed.2022.10.320
Source: Free Radical Biology and Medicine - November 5, 2022 Category: Biology Authors: Xue-Ting Li Jia-Wei Song Zhen-Zhou Zhang Mi-Wen Zhang Li-Rong Liang Ran Miao Ying Liu Yi-Hang Chen Xiao-Yan Liu Jiu-Chang Zhong Source Type: research