Filtered By:
Specialty: Drugs & Pharmacology
Education: Study
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 1993 results found since Jan 2013.
Short interfering RNA in colorectal cancer: is it wise to shoot the messenger?
This study focuses on many innovative siRNA therapies and methodologies for delivering siRNA therapeutics to the malignant site safely and effectively for the treatment of CRC. Treatment of CRC using siRNA-associated nanoparticles (NPs) may inhibit the activity of oncogenes and MDR-related genes by targeting a range of signaling mechanisms. This study summarizes several siRNAs targeting signaling molecules, as well as the therapeutic approaches that might be employed to treat CRC in the future.PMID:37011722 | DOI:10.1016/j.ejphar.2023.175699
Source: European Journal of Pharmacology - April 3, 2023 Category: Drugs & Pharmacology Authors: Kiruthiga Chandramohan Devasahayam Jaya Balan Kasi Pandima Devi Seyed Fazel Nabavi Sara Reshadat Maryam Khayatkashani Sepideh Mahmoodifar Rosanna Filosa Nilofar Amirkhalili Soroush Pishvaei Omolbanin Sargazi Aval Seyed Mohammad Nabavi Source Type: research
Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses
Discussion: To our best knowledge, our study pioneered co-delivery system for hydrophilic siCD47 and hydrophobic R848. It can maximize break tumor immune escape caused by CD47 and simultaneously enhance antigen presentation by activating DCs for effector T cell killing while regulating the tumor microenvironment as expected. Not only does it conform to the reports of previous basic research, but also it can break the bottleneck of their clinical application hopefully. Collectively, our findings could lay the foundation for future therapeutic strategies of TNBC.
Source: Frontiers in Pharmacology - March 31, 2023 Category: Drugs & Pharmacology Source Type: research
Thiram, an inhibitor of 11 ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway
CONCLUSIONS: Hydrocortisone inhibits osteosarcoma through the Wnt/β-catenin pathway. Thiram inhibits 11HSD2 enzyme activity, reducing hydrocortisone inactivation and promoting the effect of hydrocortisone through the same pathway.PMID:36978114 | PMC:PMC10045229 | DOI:10.1186/s40360-023-00655-0
Source: BMC Pharmacology and Toxicology - March 28, 2023 Category: Drugs & Pharmacology Authors: You Zhang Nanjing Li He Li Maojia Chen Wei Jiang Wenhao Guo Source Type: research
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity
CONCLUSION: This research premise established that STING inhibition could alleviate Dox-triggered cardiotoxicity in mice. As a result, preventing DIC by repressing STING in cardiomyocytes might be a possible treatment approach.PMID:36964634 | PMC:PMC10037834 | DOI:10.1186/s40360-022-00631-0
Source: BMC Pharmacology and Toxicology - March 25, 2023 Category: Drugs & Pharmacology Authors: Zilong Xiao Ziqing Yu Chaofeng Chen Ruizhen Chen Yangang Su Source Type: research
Baicalin inhibited both the Furin/TGF β1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca < sup > 2+ < /sup > /ROS pathway in platelets to ameliorate inflammatory coagulopathy
In this study, the effects of baicalin, an active component of the traditional Chinese medicine Huangqin, on inflammatory coagulopathy were observed both in vivo and in vitro. In LPS-induced rats, baicalin ameliorated coagulation indexes, inhibited platelet hyperactivation and decreased the expression of thrombospondin-1 (TSP-1) in vessels. In cultured endothelial cells, baicalin decreased the expression of TSP-1 and collagen as well as the TNF-α-induced increase in the levels of TSP-1 and ICAM-1. Baicalin could significantly decrease the platelet adhesion on endothelial cells treated with TNF-α. Baicalin also could inhi...
Source: European Journal of Pharmacology - March 24, 2023 Category: Drugs & Pharmacology Authors: Peichun Wang Jiao Wu Qiongsen Wang Shaowei Zhuang Jing Zhao Ying Yu Weidong Zhang Yuejuan Zheng Xuan Liu Source Type: research
Protective role of cytochrome c oxidase 5A (COX5A) against mitochondrial disorder and oxidative stress in VSMC phenotypic modulation and neointima formation
CONCLUSION: The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.PMID:36924093 | DOI:10.2174/1570161121666230315142507
Source: Current Vascular Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Authors: Haijing Guan Jingwen Sun Xiuying Liang Wenjuan Yao Source Type: research
