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Penicillin allergy de-labeling: Opportunities for implementation and dissemination
Ann Allergy Asthma Immunol. 2022 Dec 20:S1081-1206(22)02006-3. doi: 10.1016/j.anai.2022.12.023. Online ahead of print.ABSTRACTAlthough existing as a safety measure to prevent iatrogenic harm, unconfirmed penicillin allergy labels have a negative impact on personal and public health. One downstream effect of unconfirmed penicillin allergy is the continued emergence and transmission of resistant bacteria and associated healthcare cost. Recognizing the consequences of inaccurate penicillin allergy labels, professional and public health organizations have started promoting the adoption of proactive penicillin allergy evaluatio...
Source: Annals of Allergy, Asthma and Immunology - December 23, 2022 Category: Allergy & Immunology Authors: Upeka Samarakoon John Accarino Alysse Wurcel Jordon Jaggers Allen Judd Kimberly Blumenthal Source Type: research

Position document: IgE-mediated cow's milk allergy.
y) Abstract The present document offers an update on the recommendations for managing patients with cow's milk allergy - a disorder that manifests in the first year of life, with an estimated prevalence of 1.6-3% in this paediatric age group. The main causal allergens are the caseins and proteins in lactoserum (beta-lactoglobulin, alpha-lactoalbumin), and the clinical manifestations are highly variable in terms of their presentation and severity. Most allergic reactions affect the skin, followed by the gastrointestinal and respiratory systems, and severe anaphylaxis may occur. The diagnosis of cow's milk allergy i...
Source: Allergologia et Immunopathologia - March 19, 2015 Category: Allergy & Immunology Authors: Martorell-Aragonés A, Echeverría-Zudaire L, Alonso-Lebrero E, Boné-Calvo J, Martín-Muñoz MF, Nevot-Falcó S, Piquer-Gibert M, Valdesoiro-Navarrete L, Food allergy committee of SEICAP (Spanish Society of Pediatric Allergy, Asthma and Clinical Immunolo Tags: Allergol Immunopathol (Madr) Source Type: research

Persistent Food Allergy and Food Allergy Coexistent with Eczema Is Associated with Reduced Growth in the First 4 Years of Life
Conclusions Children with both food allergy and eczema were shorter and lighter throughout early childhood, with more pronounced differences in those with persistent food allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 4, 2015 Category: Allergy & Immunology Source Type: research

Persistent Food Allergy and Food Allergy Coexistent with Eczema Is Associated with Reduced Growth in the First 4 Years of Life
Conclusions Children with both food allergy and eczema were shorter and lighter throughout early childhood, with more pronounced differences in those with persistent food allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 8, 2016 Category: Allergy & Immunology Source Type: research

Food Allergy Sensitization and Presentation in Siblings of Food Allergic Children
Conclusions In a large cohort of food allergic families, only a small proportion of siblings were both sensitized and clinically reactive to a food. Sensitization without reactivity was common among siblings. Testing for food allergy in siblings without a history of clinical reactivity appears to be unjustified. Screening may lead to negative consequences related to potential misdiagnosis and unnecessary avoidance of a food. More data are needed to determine the absolute risk of food allergy development in siblings of food allergic children.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 12, 2016 Category: Allergy & Immunology Source Type: research

Prevalence of food allergies in South Asia.
CONCLUSION: The medical literature on the prevalence and types of food allergy in South Asia indicates that there is a variety of unusual and unique allergens and an overall low incidence of food allergy. There is also an association of increased food allergy prevalence in individuals who live in metropolitan regions or who migrate to communities that have adopted westernization. PMID: 27864090 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - November 14, 2016 Category: Allergy & Immunology Authors: Arakali SR, Green TD, Dinakar C Tags: Ann Allergy Asthma Immunol Source Type: research

Factors Associated with Development of Food Allergy in Young Children after Liver Transplantation: A Retrospective Analysis of 10  Years' Experience
Conclusions We identified eczema at liver transplantation as a significant risk factor for the development of IgE-mediated food allergy after liver transplantation, but not non–IgE-mediated food allergy. Our findings may contribute to a better understanding of the susceptible subgroup requiring special caution and to the establishment of effective strategies for prevention.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 24, 2017 Category: Allergy & Immunology Source Type: research

Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database
Conclusions Two different independent methods using clinical history predictors were unable to accurately predict beta-lactam allergy and replace a conventional allergy evaluation for suspected beta-lactam allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 21, 2017 Category: Allergy & Immunology Source Type: research

Risk of Immediate-Type Allergy to Local Anesthetics is Overestimated —Results from 5 Years of Provocation Testing in a Danish Allergy Clinic
Conclusions None of the 164 patients with suspected immediate-type allergy to LAs reacted on provocation. Thus, no patients have been diagnosed with an immediate allergy to LAs in our regional allergy clinic in the 5-year period studied, and allergy to LAs must be considered very rare. Alternative mechanisms should be considered, but if symptoms are consistent with allergy, other potential allergens should be investigated.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2017 Category: Allergy & Immunology Source Type: research

The cost of self-reported penicillin allergy: a systematic review
Conclusions Evaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 31, 2018 Category: Allergy & Immunology Source Type: research

Risk of Immediate-Type Allergy to Local Anesthetics Is Overestimated—Results from 5 Years of Provocation Testing in a Danish Allergy Clinic
ConclusionsNone of the 164 patients with suspected immediate-type allergy to LAs reacted on provocation. Thus, no patients have been diagnosed with an immediate allergy to LAs in our regional allergy clinic in the 5-year period studied, and allergy to LAs must be considered very rare. Alternative mechanisms should be considered, but if symptoms are consistent with allergy, other potential allergens should be investigated.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 5, 2018 Category: Allergy & Immunology Source Type: research

The Cost of Self-Reported Penicillin Allergy: A Systematic Review
ConclusionsEvaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Outcomes from a regional synchronous tele-allergy service
ConclusionCoupled with high patient satisfaction and significant time and cost savings, tele-allergy supported the majority of new and follow up visits without an in-person recommendation. While not all tele-allergy efforts incorporate a synchronous modality with a dedicated patient presenter, allergists should continue to seek opportunities to incorporate synchronous tele-allergy with a trained patient presenter into their clinical practice.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 30, 2018 Category: Allergy & Immunology Source Type: research

Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children
Conclusion: Our study indicates that most patients with a suspected β-lactam allergy tolerated this drug. An appropriate diagnostic allergy workup may prevent the use of less effective and more expensive alternatives.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - December 5, 2018 Category: Allergy & Immunology Source Type: research