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Interventions for preventing and treating kidney disease in IgA vasculitis
CONCLUSIONS: There are no substantial changes in conclusions from this update compared with the initial review or the previous update despite the addition of five studies. From generally low to moderate certainty evidence, we found that there may be little or no benefit in the use of corticosteroids or antiplatelet agents to prevent persistent kidney disease in children with IgAV in participants with no or minimal kidney involvement at presentation. We did not find any studies which evaluated corticosteroids in children presenting with IgAV and nephritic and/or nephrotic syndrome, although corticosteroids are recommended i...
Source: Cochrane Database of Systematic Reviews - February 28, 2023 Category: General Medicine Authors: Deirdre Hahn Elisabeth M Hodson Jonathan C Craig Source Type: research

Effect of the COVID-19 Pandemic on the Rate of Interventional Pain Management Therapies. Could the Application of Personal Protective Equipment Help?
CONCLUSION: The COVID-19 outbreak seriously affected the rates of in-person consultations and IPMT for patients with chronic pain and increased the rates of consumption of analgesia and oral steroids. Most responders reported a shortage of PPE especially ventilation appliances in workplaces. A high percentage of responders lack interest in ICP and PPE, despite the positive effects of its application on consultation and IPMT rates.PMID:36608012
Source: Pain Physician - January 6, 2023 Category: Anesthesiology Authors: Ahmed E Salem Inas F Abdelal Mohamed Ayaad Mohamed A Khashaba Doaa M Ismail Ossama Hamdy Emtethal As Ahmed Mohamed H Abdel Rahman Mohamed Lotfy Ahmed A Shama Source Type: research

Late ( ≥ 7 days) inhaled corticosteroids to reduce bronchopulmonary dysplasia in preterm infants
CONCLUSIONS: Based on the available evidence, we do not know if inhaled corticosteroids initiated from seven days of life in preterm infants at risk of developing BPD reduces mortality or BPD at 36 weeks' PMA. There is a need for larger randomised placebo-controlled trials to establish the benefits and harms of inhaled corticosteroids.PMID:36521169 | PMC:PMC9754672 | DOI:10.1002/14651858.CD002311.pub5
Source: Cochrane Database of Systematic Reviews - December 15, 2022 Category: General Medicine Authors: Wes Onland Martin Offringa Anton van Kaam Source Type: research

Smoking-Related Interstitial Fibrosis (SRIF) in Patients Presenting With Diffuse Parenchymal Lung Disease
CONCLUSIONS: SRIF can present as clinically meaningful diffuse parenchymal lung disease in relatively young heavy smokers, characterized by bilateral ground-glass opacities and a stable clinical course.PMID:36495281 | DOI:10.1093/ajcp/aqac144
Source: American Journal of Clinical Pathology - December 10, 2022 Category: Pathology Authors: Susan J Vehar Ruchi Yadav Sanjay Mukhopadhyay Avantika Nathani Leslie B Tolle Source Type: research

A Review of the Clinical Trial Landscape in Psoriasis: An Update for Clinicians
AbstractAs our understanding of the pathogenesis of psoriasis has evolved over the past two decades, so has the number of treatment options. The introduction of biologic agents targeting specific cytokines in the interleukin (IL)-23/IL-17 pathway has proven successful in promoting skin clearance among patients. However, their use is often limited owing to cost, parenteral administration, and possible reduced efficacy over time. Topical therapies have also seen limited advancement, with agents such as corticosteroids and vitamin D derivatives remaining the mainstay of treatment, despite side effects limiting their long-term...
Source: Dermatology and Therapy - November 1, 2022 Category: Dermatology Source Type: research

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