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Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research

Infliximab is the new kid on the block in Kawasaki disease: a single-centre study over 8 years from North India.
Authors: Singh S, Sharma D, Suri D, Gupta A, Rawat A, Rohit MK Abstract This was a single-centre study to evaluate the usefulness of tumour necrosis factor-α (TNF-α) blocker, infliximab (IFX), for treatment of Kawasaki disease (KD) in children in Northern Indian. The study was carried out in the Paediatric Allergy-Immunology Unit, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. The study period was January 2007 to March 2015. Review of records of 23 children with KD who had received IFX was carried out. Median age at presentation was 2 years (range 2 months to 1...
Source: Clinical and Experimental Rheumatology - April 19, 2016 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Vitamin A may help boost immune system to fight tuberculosis
Tuberculosis is a major global problem, affecting 2 billion people worldwide and causing an estimated 2 million deaths annually. Western countries are once again tackling the disease, with recent outbreaks in Los Angeles and London.   The rise of drug-resistant TB, called a "ticking time bomb" by the World Health Organization, and the high cost of fighting the disease highlight the need for new approaches to treatment.   In findings published in the March 1 issue of the Journal of Immunology, UCLA researchers investigating the role of nutrients in helping the immune system fight against major infectio...
Source: UCLA Newsroom: Health Sciences - February 25, 2014 Category: Universities & Medical Training Source Type: news