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Non-classical B Cell Memory of Allergic IgE Responses
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research