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From Myo-inositol to D-chiro-inositol molecular pathways
CONCLUSIONS: Inositol is fundamental for signal transduction in the brain, kidneys, reproductive organs and other tissues in response to neurotransmitters, hormones and growth factors. Various genes are involved in inositol metabolism and associated pathways. Altered inositol concentrations are observed in several diseases. Analysis of the genes involved in inositol metabolism may provide important information for the clinical management of these conditions.PMID:33755975 | DOI:10.26355/eurrev_202103_25279
Source: European Review for Medical and Pharmacological Sciences - March 23, 2021 Category: Drugs & Pharmacology Authors: A K Kiani S Paolacci A E Calogero R Cannarella G C Di Renzo S Gerli C Della Morte G M Busetto E De Berardinis F Del Giudice L Stuppia F Facchinetti S Dinicola M Bertelli Source Type: research

Effects of physician ’s diabetes self‐management education using JADEC Diabetes Education Card System Program and SMBG readings analyzer in individuals with type 2 diabetes: An exploratory, open‐labeled, prospective randomized clinical trial
ConclusionGreater HbA1c-lowering by physician ’s DMSE using the JADEC education tool and SMBG analyzer in individuals with type 2 diabetes receiving insulin and SMBG was suggested but not confirmed.
Source: Journal of Diabetes Investigation - June 4, 2021 Category: Endocrinology Authors: Nagaaki Tanaka, Daisuke Yabe, Kenta Murotani, Yuko Yamaguchi, Yuki Fujita, Sodai Kubota, Rena Nakashima ‐Yasuda, Saki Kubota‐Okamoto, Shinji Ueno, Yuji Yamazaki, Hitoshi Kuwata, Koin Watanabe, Takanori Hyo, Yoshiyuki Hamamoto, Takeshi Ku Tags: ORIGINAL ARTICLE Source Type: research

Effect of SGLT-2 Inhibitors on Non-alcoholic Fatty Liver Disease among Patients with Type 2 Diabetes Mellitus: Systematic Review with Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials
CONCLUSIONS: This study indicated that canagliflozin effectively improves liver function parameters among patients with diabetes, while dapagliflozin is more effective in improving glycemic indices and insulin sensitivity.PMID:34239714 | PMC:PMC8246653 | DOI:10.5001/omj.2021.62
Source: Oman Medical Journal - July 9, 2021 Category: Middle East Health Authors: Kai Wei Lee Navin Kumar Devaraj Siew Mooi Ching Sajesh K Veettil Fan Kee Hoo Inas Deuraseh Man Jun Soo Source Type: research

Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
AbstractIntroductionExercise is one of several factors known to lower the risk of developing cancer, as well as improve outcomes in patients already diagnosed. People who exercise after cancer have lower rates of cancer complications, treatment toxicities, relapse and improved survival. This review highlights the supportive data and biochemical processes, which explain these potential benefits.Sources of dataPubMed, Embase, Medline and Cochrane libraries were searched for papers which addressed the effects of exercise and physical activity on cancer for this review. The search terms used were physical activity, exercise an...
Source: British Medical Bulletin - August 23, 2021 Category: General Medicine Source Type: research

Multifaceted pathogenesis of liver steatosis in inflammatory bowel disease: a systematic review
CONCLUSIONS: In this interplay between genetic, metabolic, drug, and inflammatory factors, the underlying pathogenic mechanisms behind NAFLD in IBD are still far from clear. Further studies are needed to better clarify the role of individual components influencing the development of NAFLD in IBD.PMID:34604973 | DOI:10.26355/eurrev_202109_26800
Source: European Review for Medical and Pharmacological Sciences - October 4, 2021 Category: Drugs & Pharmacology Authors: R Spagnuolo L Abenavoli A Corea T Larussa R M Mancina C Cosco F Luzza P Doldo Source Type: research