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Specialty: Endocrinology
Drug: Insulin
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Total 24 results found since Jan 2013.
A new mutation in the CAVIN1/PTRF gene in two siblings with congenital generalized lipodystrophy type 4: case reports and review of the literature
Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and may have a genetic background. Congenital generalized lipodystrophy type 4 (CGL4) is an extremely rare subtype, caused by mutations in the polymerase I and transcript release factor (PTRF) gene. It encodes for a cytoplasmatic protein called caveolae-associated protein 1 (Cavin-1), which, together with caveolin 1, is responsible for the biogenesis of caveolae, being a master regulator of adipose tissue expandability. Cavin-1 is expressed in several tissues, including muscles, thus resulting, when dysfu...
Source: Frontiers in Endocrinology - July 12, 2023 Category: Endocrinology Source Type: research
Diabetic sarcopenia: metabolic and molecular appraisal
AbstractMyopathy is the missing slot from the routine clinical checkup for diabetic complications. Similarly, its pathophysiological, metabolic, and molecular bases are insufficiently explored. In this review, the above issues are highlighted with a focus on skeletal muscle atrophy (also described as diabetic sarcopenia), in contrast to the normal histological, physiological, and molecular features of the muscles. Literature search using published data from different online resources was used. Several diabetic myopathy etiological factors are discussed explicitly including; inflammation and immunological responses, with em...
Source: Acta Diabetologica - April 16, 2022 Category: Endocrinology Source Type: research
Regulation of 11 β-HSD1 by GH/IGF-1 in key metabolic tissues may contribute to metabolic disease in GH deficient patients
Growth Horm IGF Res. 2021 Nov 17;62:101440. doi: 10.1016/j.ghir.2021.101440. Online ahead of print.ABSTRACTPatients with growth hormone deficiency (GHD) have many clinical features in common with Cushing's syndrome (glucocorticoid excess) - notably visceral obesity, insulin resistance, muscle myopathy and increased vascular mortality. Within key metabolic tissues, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to the active glucocorticoid, cortisol (11-dehydrocorticosterone and corticosterone in rodents respectively), and thus amplifies local glucocorticoid action. We hypothesize that 11β-HSD1 exp...
Source: Growth Hormone and IGF Research - November 23, 2021 Category: Endocrinology Authors: Stuart A Morgan Darlene E Berryman Edward O List Gareth G Lavery Paul M Stewart John J Kopchick Source Type: research
Myostatin serum levels in children with type 1 diabetes mellitus
CONCLUSION: Children with T1DM have significantly higher serum levels of myostatin compared to healthy children of the same age and BMI SD. The elevated myostatin in T1DM could reflect impaired muscle function and/or glucose metabolism, or could represent a homeostatic mechanism.PMID:34486100 | DOI:10.1007/s42000-021-00317-y
Source: Hormones - September 6, 2021 Category: Endocrinology Authors: Alexandra Efthymiadou Ioannis-Anargyros Vasilakis Aristeidis Giannakopoulos Dionisios Chrysis Source Type: research
Patients with low IGF-I after curative surgery for Cushing's syndrome have an adverse long-term outcome of hypercortisolism-induced myopathy
CONCLUSION: Lower individual IGF-I concentrations six months after curative surgery for Cushing's syndrome are associated with adverse long-term myopathy outcome and IGF-I might be essential for muscle regeneration in the early phase after correction of hypercortisolism.PMID:33830940 | DOI:10.1530/EJE-20-1285
Source: European Journal of Endocrinology - April 8, 2021 Category: Endocrinology Authors: Frederick Vogel Leah Braun German Rubinstein Stephanie Zopp Sarina Benedix Holger Schneider Katrin Ritzel Katharina Schilbach Ralf Schmidmaier Felix Beuschlein Martin Bidlingmaier Martin Reincke Source Type: research
