• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
Authors: Schcolnik-Cabrera A, Dominguez-Gómez G, Chávez-Blanco A, Ramírez-Yautentzi M, Morales-Bárcenas R, Chávez-Díaz J, Taja-Chayeb L, Dueáas-González A Abstract Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expression of chemokines and growth factors involved in colon cancer, have not been previously reported to the best of our knowledge. I...
Source: Oncology Letters - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MAL protein stabilizes luminal membrane PLC β3 and negatively regulates ENaC in mouse cortical collecting duct cells.
MAL protein stabilizes luminal membrane PLCβ3 and negatively regulates ENaC in mouse cortical collecting duct cells. Am J Physiol Renal Physiol. 2019 Jul 31;: Authors: Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA Abstract Abnormally high epithelial sodium channel (ENaC) activity in the aldosterone sensitive distal nephron and collecting duct leads to hypertension. Mal is a lipid-raft-associated protein that has been previously shown to regulate NKCC2 (Na-K -2Cl co-transporter) and aquaporin-2 in the kidney, but it is not known whether it regulates renal ENaC. ENaC activity is positively...
Source: Am J Physiol Renal P... - July 30, 2019 Category: Urology & Nephrology Authors: Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA Tags: Am J Physiol Renal Physiol Source Type: research

Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer.
In this study, we investigated the reprogramming of the energy metabolism in radiosensitive and radioresistant head and neck squamous cell carcinomas (HNSCC) using a preclinical matched model of radiation resistance. Our investigation found that radioresistant rSCC-61 cells: 1. They display increased glucose uptake and decreased fatty acid uptake; 2. They deviate from the classical Warburg effect by diverting the glycolytic flux into the pentose phosphate pathway; 3. They are more dependent on glucose than glutamine metabolism to support growth; 4. They have decreased mitochondrial oxidative phosphorylation; 5. They have e...
Source: Radiation Research - March 4, 2015 Category: Physics Authors: Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM Tags: Radiat Res Source Type: research

Postprandial triglyceride‐rich lipoproteins promote invasion of human coronary artery smooth muscle cells in a fatty‐acid manner through PI3k‐Rac1‐JNK signaling
ConclusionWe demonstrate for the first time that TRLs induce hCASMCs invasion in a fatty acid dependent manner. This effect in TRLs–SFAs is mediated by the PI3k‐Rac1‐JNK, RhoA, and Rac1‐MMP2 pathways. The ingestion of MUFA, compared to other dietary fatty acids such as SFA, could be considered as a nutritional strategy to reduce the atherosclerotic plaque formation.
Source: Molecular Nutrition - February 24, 2014 Category: Nutrition Authors: Lourdes M. Varela, Beatriz Bermúdez, Almudena Ortega‐Gómez, Sergio López, Rosario Sánchez, Jose Villar, Christelle Anguille, Francisco J. G. Muriana, Pierre Roux, Rocío Abia Tags: Research Article Source Type: research