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Problems in self-management of analgesics after outpatient shoulder surgery
CONCLUSION: Problems in analgesic use after outpatient surgery include undertreatment, poor compliance, overdosage, nightly breakthrough pain and poor tolerance due to side effects. Interventional studies should target these areas.FUNDING: none.TRIAL REGISTRATION: not relevant.PMID:36331151
Source: Danish Medical Journal - November 4, 2022 Category: General Medicine Authors: Karen Toftdahl Bj ørnholdt Lone Dragnes Brix Source Type: research

Cancers, Vol. 10, Pages 492: Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
nin To date, no targeted drugs, antibodies or combinations of chemotherapeutics have been demonstrated to be more efficient than temozolomide, or to increase efficacy of standard therapy (surgery, radiotherapy, temozolomide, steroid dexamethasone). According to recent phase III trials, standard therapy may ensure a median overall survival of up to 18–20 months for adult patients with newly diagnosed glioblastoma. These data explain a failure of positive non-controlled phase II trials to predict positive phase III trials and should result in revision of the landmark Stupp trial as a historical control for ...
Source: Cancers - December 5, 2018 Category: Cancer & Oncology Authors: Aleksei A. Stepanenko Vladimir P. Chekhonin Tags: Review Source Type: research

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.
CONCLUSION: The mechanism responsible for cardiac and vascular events during carfilzomib therapy is unclear. This case report highlights that it is important to define at baseline the appropriate screening of patients undergoing carfilzomib therapy with specific monitoring and symptom management and that future large prospective controlled studies are needed to define the correct monitoring strategy in refractory and relapsed multiple myeloma and the potential mechanism of vascular events. PMID: 33525991 [PubMed - as supplied by publisher]
Source: Tumori - February 4, 2021 Category: Cancer & Oncology Tags: Tumori Source Type: research

Inflammatory and thrombotic parameters associated with the COVID-19 course in Poland (SARSTer study)
CONCLUSIONS: Severe course of the disease is associated with lower PLT and lymphocyte count, higher D-dimer, CRP, neutrophil count and IL-6 concentration. The best predictors of no clinical improvement in COVID-19 are: IL-6>100 ​pg/ml, D-dimer>1000 ​ng/ml and PLT<150,000/μl.PMID:35932632 | PMC:PMC9296792 | DOI:10.1016/j.advms.2022.07.003
Source: Advances in Medical Sciences - August 6, 2022 Category: Biomedical Science Authors: Piotr Czupryna Anna Moniuszko-Malinowska Magdalena Rogalska Dorota Zar ębska-Michaluk Beata Lorenc Marta Rorat Dorota Kozielewicz Magdalena Tudrujek-Zdunek Katarzyna Sikorska Aleksandra Berkan-Kawi ńska Beata Bolewska W łodzimierz Mazur Justyna Kowalsk Source Type: research