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Total 353 results found since Jan 2013.
Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor- α
CONCLUSION: LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα.PMID:33825402
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qi Chen Xu Qi Yu Fu Tingting Ji Ying Chao Jun Li Qinghai Meng Huimin Bian Yu Li Source Type: research
2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression
Conclusions: 2ME ameliorates IR-induced acute lung inflammation by increasing AnxA1 expression. Based on these results, 2ME may be a promising agent for attenuating IR-induced lung injury.
Source: Frontiers in Immunology - March 16, 2021 Category: Allergy & Immunology Source Type: research
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating the procontractile and prosurvival peptide apelin via a BMPR2-dependent mechanism. We found that ER-α and apelin expression were decreased in RV homogenates from patients with RVF and from rats with maladaptive (but not adaptive) RV remodeling. RV cardiomyocyte apelin abundance increased in vivo or in vitro after treatment w...
Source: Journal of Clinical Investigation - March 15, 2021 Category: Biomedical Science Authors: Andrea L. Frump, Marjorie Albrecht, Bakhtiyor Yakubov, Sandra Breuils-Bonnet, Valérie Nadeau, Eve Tremblay, Francois Potus, Junichi Omura, Todd Cook, Amanda Fisher, Brooke Rodriguez, R. Dale Brown, Kurt R. Stenmark, C. Dustin Rubinstein, Kathy Krentz, Di Source Type: research
Protective effect of estrogen receptors (ER α/β) against the intervertebral disc degeneration involves activating CCN5 via the promoter
CONCLUSIONS: Upregulation of ERα and ERβ protects the NP cell degeneration during IDD through the activation of CCN5 by binding to its promoter.PMID:33660790 | DOI:10.26355/eurrev_202102_25075
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: M-X Song X-X Ma C Wang Y Wang C Sun D-R Xu K Zhu G-H Li H Zhao C Zhang Source Type: research
