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Recurrent Immediate Hypersensitivity Reaction to Radiocontrast Media Despite Premedication Found to Be IgE-mediated
Approximately 75 million computed tomography (CT) scans are performed with radiocontrast media (RCM) annually1 and IgE-mediated immediate hypersensitivity reactions to nonionic RCM have been reported in 0.7 to 3% of patients2. Pretreatment with prednisone and diphenhydramine has significantly reduced immediate generalized reactions to RCM3. Recently, studies suggest that skin testing can support the diagnosis of an IgE-mediated reaction to RCM and can also help guide selection of an alternative RCM if subsequent RCM exposure is anticipated1,2.
Source: Annals of Allergy, Asthma and Immunology - January 12, 2020 Category: Allergy & Immunology Authors: Alex Wonnaparhown, Tarah Talakoub, Joseph Yusin, Thomas Yusin, Sherwin Hariri Tags: Letters Source Type: research

Sinus computed tomography predicts clinical response to corticosteroids in chronic rhinosinusitis with nasal polyps
ConclusionOur prospective findings validate the potential value of sinus CT scan in predicting GC-sensitivity in CRSwNP patients.
Source: Clinical and Translational Allergy - July 2, 2018 Category: Allergy & Immunology Source Type: research

Asthma and orbital immunoglobulin G4-related disease.
CONCLUSION: Asthma is commonly associated with orbital IgG4-RD and generally manifests as adult-onset bronchial wall thickening seen at computed tomography, increased serum IgG4 levels, and good rituximab response. PMID: 26782673 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 9, 2016 Category: Allergy & Immunology Authors: Baqir M, Garrity JA, Vassallo R, Witzig TE, Ryu JH Tags: Ann Allergy Asthma Immunol Source Type: research

Gamma globulin (Ig) replacement- a potential treatment in uncontrolled asthma associated with humoral immunodeficiency (huID)?
We report 5 adult cases of the rare association asthma-huID. All patients had persistent uncontrolled asthma related to recurrent sino-pulmonary infections and improved symptoms following Ig supplementation.All patients were confirmed asthma according to GINA guidelines, and bronchiectasis was excluded by chest CT scan.Two men (28 and 60-years-old) with pollens allergies, chronic rhinosinusitis, Ig G deficiency (7.8 g/l, and 7.6 g/l) despite optimal therapy had uncontrolled asthma due to recurrent sino-pulmonary infections. Both underwent surgery for nasal polyposis, but relapsed with acute sinusitis and severe asthma exac...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Tiotiu, A., Martinet, Y. Tags: 5.3 Allergy and Immunology Source Type: research