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Drug: Methotrexate
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Total 144 results found since Jan 2013.
Progressive proximal muscle weakness with subacute onset in an elderly patient: a case report
CONCLUSION: In this case, exclusion of inflammatory myopathies, metabolic muscle disorders and other neurological diseases is necessary for establishing a reliable diagnosis. In SINAM, simply discontinuing statin is often insufficient and aggressive immunosuppression or immunomodulation therapy is needed to achieve disease remission. This case aims to demonstrate that statins can induce serious muscular diseases that require aggressive immunosuppression.PMID:36544374 | DOI:10.33588/rn.7601.2021276
Source: Revista de Neurologia - December 22, 2022 Category: Neurology Authors: A Martins G Nadais M Pinto R Taipa L Costa S Pimenta Source Type: research
Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy
Intern Med. 2022 Sep 21. doi: 10.2169/internalmedicine.0202-22. Online ahead of print.ABSTRACTBecker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy. We herein report a patient diagnosed with BMD complicated with IMNM by a pathological analysis. Notably, the patient had an elevated serum anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody level. Oral g...
Source: Internal Medicine - September 21, 2022 Category: Internal Medicine Authors: Asami Munekane Yutaka Ohsawa Mariko Okubo Taiji Nagai Hirotake Nishimura Ichizo Nishino Yoshihide Sunada Source Type: research
Treatment and outcomes in anti-HMG-CoA reductase-associated immune-mediated necrotising myopathy. Comparative analysis of a single-centre cohort and published data
CONCLUSIONS: HMGCR-associated IMNM is a rare subset of myositis. With systemic treatment, patients usually achieve partial or complete remission. Optimal treatment has not been established, but glucocorticoids, azathioprine, and methotrexate are generally effective with or without intravenous immunoglobulins.PMID:35225222
Source: Clinical and Experimental Rheumatology - February 28, 2022 Category: Rheumatology Authors: Jan-Gerd Rademacher Stefanie Glaubitz Sabrina Zechel Manuela Oettler Bj örn Tampe Jens Schmidt Peter Korsten Source Type: research
Autoimmune & inflammatory nmd
We report 2 patients with onset in the first years of life. Both received corticosteroids, immunoglobulins, methotrexate, hydroxychloroquine and tacrolimus. Patient 1 has clearly improved. Patient 2 was misdiagnosed as muscular dystrophy for 15 years; nevertheless, after 4 months of therapy there was mild motor improvement. Patient 1. A 6-year-old girl presented with weakness, but her parents could not recall the beginning.
Source: Neuromuscular Disorders - September 19, 2021 Category: Neurology Authors: A. Camacho, D. Ghandour, J. De Inocencio, A. Hern ández Laín, O. Toldos, S. Vila, N. Núñez, R. Simón Source Type: research
Seronegative necrotizing autoimmune myopathy with favorable response to intravenous immunoglobulin
We describe a 68-year-old man who presented with progressive weakness in proximal muscles of all four limbs and was found to have autoantibody-negative necrotizing autoimmune myopathy (NAM). His myopathy was refractory to corticosteroids and methotrexate, but subsequently demonstrated successful response to intravenous immunoglobulin (IVIG). The patient also received rituximab, but the timing of his recovery favored IVIG as the more important factor in terms of efficacy. Treatment guidelines for seronegative necrotizing myopathies are lacking. This case suggests a potential efficacious treatment option for the seronegative...
Source: Baylor University Medical Center Proceedings - July 5, 2021 Category: Universities & Medical Training Authors: Rebecca Liu Andrew Z Fenves Samantha N Champion Jonathan Dau Source Type: research
