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Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ER β and IL-6/gp130/STAT3 signaling
ConclusionsInhibition of ER β and the IL-6/gp130/STAT3 signaling pathway by raloxifene leads to potent reduction of PDAC growth in vitro and in vivo. Our results suggest that ERβ signaling and IL-6/gp130 interaction may serve as promising drug targets for pancreatic cancer and that raloxifene may serve as an attractive ther apeutic option for PDAC patients expressing the ERβ isotype.
Source: Cellular Oncology - September 16, 2020 Category: Cancer & Oncology Source Type: research

Blocking IL-6/GP130 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity in human pancreatic cancer cells.
CONCLUSION: Our findings demonstrated that IL-6 stimulates pancreatic cancer cell proliferation, survival and glycolysis, and supported persistent IL-6 signaling is a viable therapeutic target for pancreatic cancer using IL-6/GP130 inhibitors. PMID: 29714141 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - April 30, 2018 Category: Cancer & Oncology Authors: Chen X, Tian J, Su GH, Lin J Tags: Curr Cancer Drug Targets Source Type: research

Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ER α and PPAR-γ
This study provides prospects for the development of a new therapeutic strategies against hypoxic brain injury that selectively target ERα and/or PPAR-γ.
Source: Molecular and Cellular Endocrinology - August 31, 2017 Category: Endocrinology Source Type: research

Oestrogen induced downregulation of TFPI expression is mediated by ERα
Conclusion: Our data establish a direct and time dependent regulation of TFPI expression by oestrogens through the ERα at the transcriptional level.
Source: Thrombosis Research - April 30, 2014 Category: Hematology Authors: Huda Omar Ali, Benedicte Stavik, Elisabeth Dørum, Nina Iversen, Per Morten Sandset, Grethe Skretting Tags: Coagulation and Fibrinolysis Source Type: research