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The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Discussion There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research