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Peak oral and nasal inspiratory flows in asthmatics from a low income community in Rio de Janeiro, Brazil
Peak oral (POIF) and nasal (PNIF) inspiratory flows are lacking of consistent published studies. Evaluate nasal and lung flows patency by these methods can open new perspectives of a detailed diagnosis, and, by consequence, a more precise asthma/rhinitis treatment and monitoring.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Marta Machado, Andrea Venerabile, Aniela Bonorino Xexeo Castelo Branco, Eliane Fonseca Source Type: research

In silico Analysis Of Alterations In ANGPT1 Gene Supports A New Pathway Responsible To Mediate Hereditary Angioedema In Brazilian Patients With No Mutations In SERPING1 And F12 Genes
Hereditary angioedema (HAE) is classified as: C1-INH-HAE with mutations in SERPING1 gene and C1-INH deficiency; FXII-HAE characterized by mutation in F12 gene and normal C1-INH and U-HAE with normal C1-INH but unknown pathogenesis. Angiopoietin 1 antagonizes the action of VEGF on vascular permeability, suggesting that an alteration of this gene could lead to the increase permeability and to trigger edema.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Nath ália Cagini, Camila Lopez Veronez, Bruna Franca Azevedo, Rosemeire Navickas Constantino-Silva, Renan Paulo Martin, Jane da Silva, Anete S. Grumach, João Bosco Pesquero Source Type: research

Paracetamol tolerance in children with non-steroidal anti-inflammatory hypersensitivity reactions
Non-steroidal anti-inflammatory drugs (NSAIDs) are present in about one third of pediatric prescriptions, and are the main cause of drug hypersensitivity reactions in Brazil.The aim of this study is to assess paracetamol tolerance in children with NSAID hypersensitivity history and to describe the clinical profile.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Anna Paula Marques Mambriz Source Type: research

On-demand intermittent beclomethasone is effective for mild asthma in Brazil
ConclusionClinicians might consider intermittent inhaled steroid therapy as a therapeutic regimen for mild persistent asthma.Trial registration The Portuguese and English versions of the study protocol were submitted, approved, and registered in the Brazilian Network Platform for Clinical Trials (http://www.ensaiosclinicos.gov.br) under the primary identifier number “RBR-3gbyhk”. This platform is part of the Primary Registries in the World Health Organization Registry Network, where the trial is registered under the following Universal Trial Number: 1111-1149-4774
Source: Clinical and Translational Allergy - March 5, 2018 Category: Allergy & Immunology Source Type: research

Evaluation of nickel and cobalt release from mobile phone devices used in Brazil
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Undifferentiated pleomorphic sarcoma
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Methotrexate-induced mucositis with extra-mucosal involvement after acidental overdose
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Urban American cutaneous leishmaniasis
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Topical corticosteroid therapy: a treatment option for nevus lipomatosus cutaneous superficialis?
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Giant onychomatricoma
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Fox-Fordyce disease
Abstract: Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
Source: Anais Brasileiros de Dermatologia - April 5, 2018 Category: Dermatology Source Type: research

Estimated cost of asthma in outpatient treatment: a real-world study
CONCLUSIONS Asthma medications, environmental control measures, and long-term health leaves had the greatest potential impact on total cost variation. The results are an estimate of the cost of treating asthma at a secondary level in the Brazilian Unified Health System, assuming that the treatment used represents the ideal approach to the disease.RESUMO OBJETIVO Estimar o custo do diagn óstico e tratamento da asma. MÉTODOS Foi utilizada a perspectiva da sociedade. Foram incluídos por 12 meses em 2011 – 2012, sequencialmente, 117 indiv íduos maiores de cinco anos de idade, em tratamento por asma nos Serviços de Pneum...
Source: Revista de Saude Publica - April 9, 2018 Category: International Medicine & Public Health Source Type: research

Tree nut allergens
Publication date: Available online 19 April 2018 Source:Molecular Immunology Author(s): Sabine Geiselhart, Karin Hoffmann-Sommergruber, Merima Bublin Tree nuts are considered as part of a healthy diet due to their high nutritional quality. However, they are also a potent source of allergenic proteins inducing IgE mediated hypersensitivity often causing serious, life-threatening reactions. The reported prevalence of tree nut allergy is up to 4.9% worldwide. The general term “tree nuts” comprises a number of nuts, seeds, and drupes, derived from trees from different botanical families. For hazelnut and walnut several al...
Source: Molecular Immunology - April 20, 2018 Category: Allergy & Immunology Source Type: research

Severe asthma is associated with metabolic syndrome in Brazilian adolescents
Asthma is a serious health problem in developing countries, with increasing prevalence over the last decades, especially among children and adolescents.1 In Brazil, according to the International Study of Asthma and Allergies in Childhood, the prevalence of active asthma in children aged 6 to 7  years and adolescents aged 13 to 14 years was, respectively, 24.3% and 19%, one of the highest among Latin American countries.2
Source: Journal of Allergy and Clinical Immunology - February 7, 2018 Category: Allergy & Immunology Authors: F ábio Chigres Kuschnir, Mara Morelo Rocha Felix, Maria Cristina Caetano Kuschnir, Kátia Vergetti Bloch, Erica Azevedo de Oliveira Costa Jordão, Dirceu Solé, Antônio José Ledo Alves da Cunha, Moyses Szklo Tags: Letter to the Editor Source Type: research

Brazilian artisanal ripened cheeses as sources of proteolytic lactic acid bacteria capable of reducing cow milk allergy
Journal of Applied Microbiology, EarlyView.
Source: Journal of Applied Microbiology - May 4, 2018 Category: Microbiology Authors: V. Biscola , Y. Choiset , H. Rabesona , J. ‐M. Chobert , T. Haertlé , B.D.G.M. Franco Source Type: research

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