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Specialty: Neurology
Condition: Disability

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Total 4114 results found since Jan 2013.

Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions—Our randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02549846.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Shinichi Yoshimura, Kazutaka Uchida, Takashi Daimon, Ryuzo Takashima, Kazuhiro Kimura, Takeshi Morimoto, on behalf of ASSORT Trial Investigator* Tags: Clinical Studies, Lipids and Cholesterol, Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke Brief Report
Background and Purpose—Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke.Methods—Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, ≥3) at 3 months after stroke.Results—Compared with the lowest qua...
Source: Stroke - December 22, 2017 Category: Neurology Authors: Aili Wang, Chongke Zhong, Zhengbao Zhu, Tian Xu, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Jianhui Zhang, Xiaodong Yuan, Jing Chen, Yonghong Zhang, Jiang He Tags: Biomarkers, Clinical Studies, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Motor imagery as a complementary technique for functional recovery after stroke: a systematic review.
Conclusions: The use of MI combined with conventional rehabilitation is an effective method for the recovery of functionality after stroke. Due to the great heterogeneity in the scientific literature available, new lines of research are necessary, in order to include well-designed studies of good methodological quality and to establish a consensus regarding the most appropriate protocols. PMID: 31347992 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - July 25, 2019 Category: Neurology Authors: López ND, Monge Pereira E, Centeno EJ, Miangolarra Page JC Tags: Top Stroke Rehabil Source Type: research

Outcomes of a Contemporary Cohort of 536 Consecutive Patients With Acute Ischemic Stroke Treated With Endovascular Therapy Clinical Sciences
Conclusions— This study reinforces the role of revascularization and time to treatment to achieve enhanced functional outcomes and identifies other clinical features that independently predict good/fatal outcome after endovascular treatment/therapy.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Abilleira, S., Cardona, P., Ribo, M., Millan, M., Obach, V., Roquer, J., Canovas, D., Marti-Fabregas, J., Rubio, F., Alvarez-Sabin, J., Davalos, A., Chamorro, A., de Miquel, M. A., Tomasello, A., Castano, C., Macho, J. M., Ribera, A., Gallofre, M., on beh Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research

Efficacy and task structure of bimanual training post stroke: a systematic review.
Conclusion: There were not enough data to draw any conclusions about the effects of bimanual task symmetry or commonality of goal. PMID: 24985386 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - May 1, 2014 Category: Neurology Authors: Wolf A, Scheiderer R, Napolitan N, Belden C, Shaub L, Whitford M Tags: Top Stroke Rehabil Source Type: research

Selecting measures for balance and mobility to improve assessment and treatment of individuals after stroke.
This article utilizes a case-based approach to describe the benefits of using a common set of outcome measures and a process for selecting optimal measures across body structure/function, activity, and participation domains of the International Classification of Functioning, Disability and Health (ICF) model and stages of stroke recovery. Specific measures for use in acute care, rehabilitation, outpatient, and home health care settings are discussed based on StrokEDGE task force recommendations by the Neurology Section of the American Physical Therapy Association. PMID: 25150662 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - July 1, 2014 Category: Neurology Authors: Kegelmeyer DA, Kloos AD, Siles AB Tags: Top Stroke Rehabil Source Type: research

Cost-Effectiveness of Recombinant Tissue-Type Plasminogen Activator Within 3 Hours of Acute Ischemic Stroke: Current Evidence Clinical Sciences
Conclusions— Our analysis supports earlier economic evaluations that r-tPA is a cost-effective method to treat stroke. Appropriate use of r-tPA should be prioritized nationally.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Boudreau, D. M., Guzauskas, G. F., Chen, E., Lalla, D., Tayama, D., Fagan, S. C., Veenstra, D. L. Tags: Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Seven capital devices for the future of stroke rehabilitation.
Authors: Iosa M, Morone G, Fusco A, Bragoni M, Coiro P, Multari M, Venturiero V, De Angelis D, Pratesi L, Paolucci S Abstract Stroke is the leading cause of long-term disability for adults in industrialized societies. Rehabilitation's efforts are tended to avoid long-term impairments, but, actually, the rehabilitative outcomes are still poor. Novel tools based on new technologies have been developed to improve the motor recovery. In this paper, we have taken into account seven promising technologies that can improve rehabilitation of patients with stroke in the early future: (1) robotic devices for lower and upper ...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

What is the effect of additional physiotherapy on sitting balance following stroke compared to standard physiotherapy treatment: a systematic review.
CONCLUSION: The current evidence supports strategies that target deficits at the activity level and increase total treatment time. The TIS is most responsive as a measure of treatment efficacy. Further research is required using recommended outcome measures to facilitate generation of a minimum data set and data pooling. PMID: 26086177 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - June 18, 2015 Category: Neurology Authors: Bank J, Charles K, Morgan P Tags: Top Stroke Rehabil Source Type: research

Why Clinicians Prognosticate Stroke Patients Poorly: Results from the Clinician Judgment versus Risk Score to Predict Stroke Outcomes Randomized Study
Prognostication after a stroke has important implications for care and for decisions made by patients and their families. It is not clear why clinicians, even experienced stroke neurologists, poorly estimate the risk of disability and death following stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 14, 2016 Category: Neurology Authors: Nav Persaud, Kevin E. Thorpe, Stavroula R. Raptis, Gustavo Saposnik, Stroke Outcomes Research Working Group (SORCan—) Source Type: research

20-Hydroxyeicosatetraenoic Acid as a Predictor of Neurological Deterioration in Acute Minor Ischemic Stroke Brief Report
Conclusions—ND is fairly common in acute minor ischemic stroke and is associated with poor prognosis. Elevated plasma level of 20-HETE may be a predictor for ND in acute minor ischemic stroke.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Xingyang Yi, Zhao Han, Qiang Zhou, Jing Lin, Ping Liu Tags: Biomarkers, Clinical Studies, Quality and Outcomes, Ischemic Stroke Brief Reports Source Type: research

Successful Reperfusion With Mechanical Thrombectomy Is Associated With Reduced Disability and Mortality in Patients With Pretreatment Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Score
Background and Purpose—In acute ischemic stroke patients, diffusion-weighted imaging (DWI)–Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented in the recent randomized mechanical thrombectomy trials. Our aim was to assess the impact of reperfusion in pretreatment DWI-ASPECTS ≤6 patients treated with mechanical thrombectomy.Methods—We analyzed data collected between January 2012 and August 2015 in a bicentric prospective clinical registry of...
Source: Stroke - March 27, 2017 Category: Neurology Authors: Jean–Philippe Desilles, Arthuro Consoli, Hocine Redȷem, Oguzhan Coskun, Gabriele Ciccio, Stanislas Smaȷda, Julien Labreuche, Cristian Preda, Clara Ruiz Guerrero, Jean–Pierre Decroix, Georges Rodesch, Mikael Mazighi, Raphael Blanc Tags: Magnetic Resonance Imaging (MRI), Revascularization, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

Mortality Reduction for Fever, Hyperglycemia, and Swallowing Nurse-Initiated Stroke Intervention Clinical Sciences
Background and Purpose—Implementation of nurse-initiated protocols to manage fever, hyperglycemia, and swallowing dysfunction decreased death and disability 90 days poststroke in the QASC trial (Quality in Acute Stroke Care) conducted in 19 Australian acute stroke units (2005–2010). We now examine long-term all-cause mortality.Methods—Mortality was ascertained using Australia’s National Death Index. Cox proportional hazards regression compared time to death adjusting for correlation within stroke units using the cluster sandwich (Huber–White estimator) method. Primary analyses included treatment group only unadju...
Source: Stroke - April 24, 2017 Category: Neurology Authors: Sandy Middleton, Kelly Coughlan, George Mnatzaganian, Nancy Low Choy, Simeon Dale, Asmara Jammali–Blasi, Chris Levi, Jeremy M. Grimshaw, Jeanette Ward, Dominique A. Cadilhac, Patrick McElduff, Janet E. Hiller, Catherine D’Este Tags: Clinical Studies, Nursing, Treatment, Mortality/Survival, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Refining 3 Measures to Construct an Efficient Functional Assessment of Stroke Clinical Sciences
We examined the psychometric properties of the FAS, including Rasch reliability, concurrent validity, convergent validity, known-group validity, and responsiveness.Results—The FAS contained 29 items (10, 6, 8, and 5 items for the 4 short-form tests, respectively). The FAS demonstrated high Rasch reliability (0.92–0.94), concurrent validity (r=0.90–0.97 with the original tests), convergent validity (r=0.62–0.94 with the 5-scale Fugl-Meyer Assessment), and known-group validity (significant difference in the FAS scores among 3 groups of disability levels; P
Source: Stroke - May 22, 2017 Category: Neurology Authors: Yu-Lin Wang, Gong-Hong Lin, Yi-Jing Huang, Mei-Hsiang Chen, Ching-Lin Hsieh Tags: Rehabilitation, Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Contralesional Brain-Computer Interface Control of a Powered Exoskeleton for Motor Recovery in Chronic Stroke Survivors Clinical Sciences
Conclusions—The findings demonstrate the therapeutic potential of a BCI-driven neurorehabilitation approach using the unaffected hemisphere in this uncontrolled sample of chronic stroke survivors. They also demonstrate that BCI-driven neurorehabilitation can be effectively delivered in the home environment, thus increasing the probability of future clinical translation.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02552368.
Source: Stroke - June 26, 2017 Category: Neurology Authors: David T. Bundy, Lauren Souders, Kelly Baranyai, Laura Leonard, Gerwin Schalk, Robert Coker, Daniel W. Moran, Thy Huskey, Eric C. Leuthardt Tags: Rehabilitation, Cerebrovascular Disease/Stroke Original Contributions Source Type: research